Pharmacodynamics and pharmacokinetics
Indinol Forto is a universal hyperplastic corrector of various pathological processes in the organs and tissues of the woman’s reproductive system, including: mammary glands, ovaries, endometrium, myometrium, cervix.
The drug has a normalizing effect on the balance of estrogen in the female body, suppresses the negative stimulating effect of the latter, and blocks other hormone-independent mechanisms that activate the pathological growth of cells in the mammary glands and uterus.
It has selective stimulation of the death of transformed cells with unusually high proliferative activity.
Indications for use
- for the treatment of fibrocystic mastopathy, as well as for the correction of the functional states of the mammary glands caused by this pathology;
- in combination with Epigallate in the complex therapeutic treatment of endometriosis, adenomyosis, uterine fibroids and endometrial hyperplasia without atypia, as well as for the prevention of relapse of these diseases after surgical treatment;
- in the complex treatment of genital diseases in women associated with the human papillomavirus: cervical dysplasia (intraepithelial cervical neoplasia), anogenetic condylomatosis.
Side effects
All side effects are mild and can be relieved independently or with symptomatic therapy. The following side effects have been reported from individual body systems:
Reproductive system
Irregularities in the menstrual cycle, for example, lengthening or shortening the cycle.
Digestive organs
Epigastric pain.
Laboratory indicators
An increase in the concentration of thyroid-stimulating hormone and follicle-stimulating hormone , as well as prolactin , estradiol .
Decreased creatinine , development of eosinophilia (increased number of eosinophils).
Among others
Weight loss.
Overdose
An overdose of the drug Indinol Forto can lead to upset of the digestive system and also cause the following reactions in the body:
- nausea and vomiting;
- pain in the central and lower abdomen, accompanied by diarrhea;
- the appearance of a red rash on the surface of the abdomen and other parts of the body;
- urticaria and swelling of epithelial tissues;
- incessant itching of the skin, which is one of the manifestations of an acute allergic reaction;
- frequent urge to urinate, which also indicates individual intolerance to the medication and irritation of the mucous membrane of the genitourinary system;
- headache, general malaise and physical weakness.
Patients who have concomitant liver and kidney diseases associated with impaired functional activity may experience an exacerbation of these ailments.
In this case, the addition of concomitant symptoms associated with pathologies of these organs cannot be excluded. The severity of overdose symptoms depends on how much of the drug was taken in a short period of time.
A specific antidote that neutralizes the effect of the active component of the drug is unknown. In case of an overdose, you must notify your doctor, take the sorbent drug and call an ambulance.
Further therapy is symptomatic and depends on the patient’s health condition. Activated carbon, Atoxil, Enterosgel, Smecta are used as sorbent preparations.
Interaction
with indirect anticoagulants , glucocorticosteroids , oral hypoglycemic agents, antiarrhythmics , antiepileptics , and digitalis drugs, since cytochrome P 450 isoenzymes , the activity of which is influenced by indole carbinol . Dose adjustment may be necessary.
Drug interactions and special instructions
Before starting to take the drug, it is recommended to undergo sensitivity tests to the composition of the drug in order to avoid possible intolerance to individual components of the drug.
The drug is not compatible with drugs that reduce the acidity of the gastric environment; it is not recommended. The components that make up Indinol can cause pain if used together with medications prescribed for peptic ulcers.
The use of the drug during pregnancy and breastfeeding is prohibited. The dietary supplement is not intended for use in children.
Long-term use of the drug does not affect the speed of reactions, therefore, during therapy or prophylaxis, the patient can drive a car and do any work associated with increased concentration and requiring a high reaction speed.
The drug can be used together with vitamin complexes after surgery or chemotherapy after treatment for cancer of the uterus and ovaries.
Analogues of Indinol Forto
Structural analogues of the active substance
- Indinol + Epigallate;
- Intrinol.
Analogs for pharmacological effect
- Agnucaston;
- Mastodinon;
- Progestogel;
- Cyclodinone.
Some analogues are cheaper.
Compound
Indinol Forto (reviews from women are positive and indicate an excellent therapeutic effect that occurs after taking the drug) contains an active substance called indolecarbinol (with a concentration of 0.200 g in 1 dose). This biochemical compound provides the antiestrogenic and antitumor properties of the drug.
Auxiliary components of Indinol Forto are:
- lactose monohydrate with a concentration of 0.140 g;
- magnesium stearate with a mass fraction of the substance of 0.001 g;
- corn starch (part of the capsule shell) in the amount of 0.095 g;
- purified microcrystalline cellulose in the amount of 0.064 g.
Excipients ensure the preservation of the pharmacological properties of indole carbinol, and also contribute to its better absorption in the gastrointestinal tract.
Reviews of Indinol Forto
Reviews for mastopathy
You can find reviews from patients who have tried many means of combating breast cysts and settled on Indinol Forto. They claim that the effect is noticeable within a month: chest pain and existing lumps disappear. Many are satisfied with the drug and recommend it to everyone.
Reviews from doctors
The experience of using this drug in medical practice indicates the effectiveness of the drug as a modulator of the cytochrome system for cyclic mastalgia . The frequent prescription is due to the small list of side effects and low toxicity of the drug.
Pharmadynamics
Indinol Forto (reviews from women confirm the positive properties of the drug) is a drug that has the ability to cause selective death of degenerated cells, which can form the basis of a cancerous tumor.
The active substance indolecarbinol has a modeling effect on the cytochrome system of the endocrine glands.
The process of formation of the cytochrome isoform occurs with further hydroxylation of estrogens in the second position and the production of 2-hydroxyestrone.
The metabolite, which is synthesized as a result of the above biochemical reaction, is an antagonist of the sex hormone receptor - estrogen. The activity of genes, the induction of which depends on the level of estrogen in the blood serum, is suppressed, and the tissues and cells of the female reproductive system are no longer stimulated by sex hormones.
A course of medication is indicated for the prevention and comprehensive fight against diseases caused by estrogen hyperactivity. Indinol also helps eliminate the feeling of pain in the glandular tissues of the breast in patients with mastodynia.
Indinol Forto price, where to buy
You can buy Indinol Forto in capsules 200 mg, package No. 60, for an average of 2,500 rubles in Moscow, Novosibirsk, Saratov, and other cities.
The price of Indinol Forto at the Ozerki pharmacy in St. Petersburg is approximately 2,650 rubles.
Packs of 120 capsules are not sold.
- Online pharmacies in RussiaRussia
ZdravCity
- Indinol Forto capsules 200 mg 60 pcs. JSC MiraxBioPharma
RUB 2,346 order
Contraindications
Despite the fact that Indinol Forto is considered a safe drug, it is strictly contraindicated for use in the following cases:
- the patient’s tendency to have an allergic reaction to the main or auxiliary components of the drug, which is expressed in the appearance of a red rash, hives, itchy skin, swelling, and digestive disorders (ignoring this contraindication can lead to the opposite effect and deterioration of the patient’s well-being);
- congenital galactose intolerance, acute lactase deficiency;
- the patient's age is under 18 years;
- concomitant use of medications, the active components of which cause a decrease in the concentration of gastric juice.
The attending physician who examined the patient may discover other risk factors or concomitant diseases of the body that exclude the possibility of using Indinol Forto capsules for complex treatment of pathologies of the female reproductive system.
Reviews of drugs from patients and doctors
In search of the most effective drugs, patients often turn to reviews and opinions of other patients with similar symptoms who are currently undergoing treatment or have already completed a course of treatment.
Most of the patients who took the drugs Indinol and Indinol Forto give positive reviews about it: signs of mastopathy disappear, and the results of ultrasound examinations, which are carried out after completion of the course of treatment, show that cystic formations decrease or completely disappear.
It is obvious that patients who observe positive dynamics when using the drug recommend these medications. Other patients have a negative attitude towards taking these drugs, describing them as ineffective and useless drugs, the price of which is overpriced for no apparent reason.
As in the situation with patients, there is no general consensus among gynecologists about how effective the drugs Indinol and Indinol Forto are.
Doctors treat the use of these drugs with a high degree of caution. However, the positive results of treatment for mastopathy among patients who underwent comprehensive treatment convince doctors that these medications are advisable to use in treatment.
They can be prescribed without fear in the complex treatment of diseases of the female reproductive and reproductive system, due to their extremely low toxicity. But despite this fact, you should not self-medicate and take medications without consulting a doctor.
They should be prescribed only after collecting a complete history and studying hormonal levels, as well as the need for its correction.
Directions for use and dosage
According to the instructions, Indinol can be taken together with other dietary supplements, but strictly as prescribed by the attending physician and in accordance with his instructions. For various pathologies, the following treatment regimens are indicated:
- Mastopathy – 1-2 capsules, with meals, once or twice a day, for 1-3 months. After a break of 2-3 months, it is recommended to do an ultrasound of the mammary glands and, if necessary, take a second course.
- Endometrial hyperplasia, adenomyosis, endometriosis or uterine fibroids - together with the Epigallate supplement, 1-2 capsules of Indinol once a day, along with meals. The duration of treatment depends on the clinical effect, varies between 2-3 weeks. For uterine fibroids, to ensure a more sustainable therapeutic effect, the daily dose can be doubled, and the duration of use can be up to 2-3 months.
- For conditions caused by papillomavirus - together with immunomodulators, 1 capsule 1 time, daily for 10-15 days. Doctors recommend that the patient’s sexual partner undergo a similar course of treatment.
