Release form and composition
The drug is available in the form of hard gelatin capsules of two types:
- Indinol (10 pcs. in a blister, 3 blisters per package; 60, 90 or 120 pcs. in polymer bottles);
- Indinol Forto (20 pcs. in a blister, 3 or 6 blisters per package; 60, 90 or 120 pcs. in polymer bottles).
The active component is indole-3-carbinol, a substance obtained by extraction from cruciferous plants. Indinol contains 100 mg (the package says “300 mg”, but 300 means the total weight of the capsule, not the content of the active substance), and Indinol Forto contains 200 mg.
Additional components: modified corn starch, lactose monohydrate, microcrystalline cellulose, magnesium stearate.
Pharmacokinetics
Indinol Forto belongs to the pharmacological group of non-toxic drugs. The medication is taken orally, and the dissolution of the capsule with the release of the active substance occurs in the large intestine.
The constituent components of the drug penetrate the bloodstream, along with which they enter the tissues of the reproductive system and endocrine glands.
The final stage of metabolic breakdown of the drug components occurs in the liver. About 95% of the components of the drug are excreted by the kidneys along with urine. The remaining metabolites are eliminated from the body as part of the feces.
Indications for use
Indinol is a drug intended for pathogenetic and anti-relapse therapy of hyperplastic processes in breast tissue and other estrogen-dependent organs. As a source of indole-3-carbinol, Indinol normalizes estrogen levels and suppresses their negative stimulating effect, blocks other hormone-independent mechanisms that activate pathological cellular growth in the tissues of the mammary gland and uterus, causes selective death of cells with abnormally high proliferative activity, stimulates the development of healthy cells .
Due to these properties of indole-3-carbinol, Indinol is used for:
- Treatment of cyclic mastalgia, including benign mammary hyperplasia;
- Treatment and prevention of fibrocystic mastopathy;
- Correction of functional disorders in the mammary gland caused by mastopathy.
As part of complex therapy, the dietary supplement is recommended to be taken for diseases of the genital area in women caused by the human papillomavirus, including intraepithelial cervical neoplasia and anogenital condylomatosis.
In combination with Epigallate, Indinol is prescribed for uterine fibroids, adenomyosis, endometrial hyperplasia (without atypia), endometriosis, as well as for the prevention of relapse of these diseases after their surgical treatment.
Indinol in combination with Epigallate
Currently, an innovative technique is being used that increases the effectiveness of fibroid treatment. To do this, Indinol will be used in combination with Epigallate, which is also a non-hormonal agent. The action of this complex is based on the suppression of tumor cell division processes, which stops its further growth.
Acting on already formed fibroids, the drug prevents the formation of new blood vessels in it. Insufficient supply of oxygen and nutrients to degenerative cells slows down their development and division, they cease their vital functions, often with the complete disappearance of the nodes. Complex treatment with these drugs is not accompanied by side effects, and its use in cases where the stage of fibroids allows you to get rid of the tumor only through surgery, this method eliminates the possibility of relapse in the form of the formation of new tumor foci.
Directions for use and dosage
The dietary supplement should be taken with meals. As a rule, 200 mg of indole-3-carbinol (2 capsules of Indinol or 1 capsule of Indinol Forto) is prescribed twice a day.
The course of treatment for fibrocystic mastopathy is 6 months.
For genital diseases associated with human papillomavirus, Indinol (at the same dose) is prescribed in combination with immunomodulators. Both sexual partners should undergo treatment. Duration of treatment is 3-6 months.
For uterine fibroids, adenomyosis, endometrial hyperplasia without atypia, endometriosis, Indinol (in a similar dosage) is prescribed in combination with Epigallate (also 2 capsules twice a day). The drug should be taken for medicinal purposes for 6 months, to prevent relapses - for 3 months.
Analogues of the drug
Indinol analogues based on the active compound are not produced. If it is necessary to replace the drug, the doctor can select drugs that are substitutes for Indinol, which are similar to it in the mechanism of action and belonging to the same pharmacological group.
Such substitutes are:
- Mastodion. The drug contains a complex of 6 herbal components as an active component. The preparation contains extracts of chasteberry, cohosh, cyclomena europaea, chilibucha ignatia, iris multicolored and tiger lily. The medication is available in the form of drops for oral administration and homeopathic tablets intended for resorption. The solution for internal use is an aromatic, slightly yellowish, transparent liquid. Its taste is initially sweetish, then changes to pungent and bitter. The medication has a small number of contraindications and side effects. Mastodion refers to medications that are intended for over-the-counter sale. The medication should be stored in a dry place, protected from light and out of reach of children, at a temperature of no more than 25 degrees Celsius. The shelf life of the medicine is 36 months. The price of the medication in the form of a solution is 480 rubles per 50 ml bottle, tablets cost 390 rubles per package.
- Remens is produced in the form of tablets and homeopathic drops. The drug contains cohosh, cuttlefish gland secretion, Sanguinaria pilocarpus extract and surukuku poison as active ingredients. Additional components of the product in tablet form are lactose monohydrate, starch and magnesium stearate. The bulk-forming compound in the droplets is ethylene. The medication is used to normalize the balance in the hypothalamic-pituitary-ovarian system during menopause. The drug has a minimum number of contraindications and side effects. The drug is sold without a prescription. The shelf life is 3 years for tablets and 5 years for drops. The product must be stored in a dark place at a temperature not exceeding 25 degrees Celsius. The price of drops is 400-500 rubles for a 50 ml bottle and 335-430 rubles for a package of tablets.
- Mastofit is a medicinal product that contains broccoli and fucus cabbage concentrate as active ingredients. Calcium stearate is used as a formative component. The medication is produced in the form of capsules and tablets. Both dosage forms contain 20 mg of fucus extract and 178 mg of broccoli concentrate. The medicine has an antioxidant and oncoprotective effect on the body. The drug is not a drug; it is recommended as a dietary supplement for women—a source of flavonoglycosides. The composition has a minimum number of contraindications and side effects. Sales in pharmacies are carried out without presenting a prescription from the attending physician. The shelf life is 2 years at a temperature of no more than 25 degrees Celsius. The cost of tablets in pharmacies ranges from 178 to 200 rubles per pack.
In addition to these drugs, Estrovel, Epigallat, Biolift, Artemis, Femsin, Klimaton, Gemafemin and some others can be used as Indinol analogues.
Side effects
According to preclinical and clinical studies, when Indinol is taken in therapeutic doses, the drug is generally well tolerated.
In individual cases the following are possible:
- Menstrual irregularities;
- Pain in the epigastric region;
- Decreased creatinine concentration, eosinophilia, increased levels of prolactin, estradiol, follicle-stimulating and thyroid-stimulating hormones.
It is worth noting that the number of patients with adverse events from women receiving placebo differs only slightly - 26.9% for Indinol and 20.0% for placebo. All identified side effects were mild and mostly went away on their own; in some cases, symptomatic therapy was required.
In case of an overdose of indole-3-carbinol, nausea, vomiting and diarrhea occur. There is no specific antidote. Treatment is symptomatic.
Useful tips
The use of Indinol for therapeutic or prophylactic purposes does not have a significant effect on the speed of reactions and concentration. There is no disruption of the central nervous system even with prolonged use of the capsules. If no side effects occur, then driving vehicles is permitted.
Drinking alcohol during a course of taking Indinol can lead to the development of undesirable reactions from any of the vital systems. Doctors recommend abandoning them throughout the entire preventive or therapeutic course.
special instructions
The dietary supplement Indinol is not a medicine. Before use, consultation with a doctor is required!
Indole-3-carbinol affects the activity of cytochrome P450 isoenzymes, therefore Indinol should be used with caution in patients taking drugs in the metabolism of which these isoenzymes are involved - with antiarrhythmics, oral hypoglycemic and antiepileptic drugs, indirect anticoagulants, glucocorticosteroids, digitalis and sex hormones (dosage adjustments may be required).
Best before date
24 months
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The description of vitamin Indinol is intended for informational purposes only. Before starting to use any drug, it is recommended to consult a doctor and read the instructions for use. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the project does not replace consultation with a specialist and cannot be a guarantee of the positive effect of the drug you use. The opinions of EUROLAB portal users may not coincide with the opinions of the site Administration.
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