The drug "Clopixol Depot" is a representative of the pharmacotherapeutic group "Neuroleptics". The drug is a long-term drug with prolonged action. This helps reduce the frequency of disease relapses, especially when patients interrupt the course on their own.
Indications for the use of Clopixol Depot are maintenance therapy for the following diseases:
- Schizophrenia in acute and chronic stages
- Chronic psychoses with the development of hallucinations, delusions
- Impaired mental activity with increased agitation, aggressiveness, and hostility.
Compound
zuclopenthixol hydrochloride as an active ingredient .
Additional components: potato starch, MCC, glycerin , hydrogenated castor oil, hypromellose, titanium dioxide, lactose, copolyvidone, talc, magnesium stearate, macrogol, red iron oxide.
zuclopenthixol acetate as the active substance , and Clopixol Depot has zuclopenthixol decanoate . Additional components in these medications are argon RM1137 and medium chain triglycerides .
Pharmacodynamics and pharmacokinetics
The drug in all forms blocks dopamine receptors in the brain. It is considered an effective corrector of psychopathic behavior. Increases prolactin .
The active substance of the drug helps to stop the nuclear symptoms of schizophrenia : hallucinations , impaired thinking, mania. In addition, it causes a sedative effect and reduces the manifestation of associated symptoms: hostility, anxiety , suspicion and aggressiveness. Accustomion to the nonspecific sedative effect develops quickly.
The maximum content of the active substance of the tablets in the blood serum is observed after 4 hours. The medicine can be taken regardless of food. Bioavailability approximately 44%. The degree of binding to plasma proteins is approximately 99%. The half-life is about 20 hours. It is excreted from the body in feces and urine.
The active substance penetrates the placental barrier . A small amount is excreted into breast milk.
Equilibrium concentration is reached after approximately 4 days.
When using injections, a pronounced effect can be observed after 4 hours. A slightly greater effect is noticeable 1-3 days after internal administration. Then it declines.
One injection of zuclopenthixol acetate promotes a pronounced and rapid reduction in the manifestations of psychotic symptoms . The effect of the drug lasts 2-3 days. As a rule, 1-2 injections are enough for the desired effect to be achieved. Oral or other deposited forms can then be taken .
After injection of zuclopenthixol acetate, a transient dose-dependent sedation occurs . It is usually done in the initial phase of psychosis , as it calms the patient until the antipsychotic effect . After internal administration, the sedative effect appears quite quickly and becomes pronounced after 2 hours. The maximum is reached after 8 hours. Then the effect begins to weaken, even if there have been repeated injections.
After administration of the drug zuclopenthixol acetate is broken down. The half-life is about 32 hours. The maximum content in blood serum is after 1-2 days. The degree of binding to plasma proteins is high. To a small extent, it passes through the placental barrier . Some amounts are excreted into breast milk. Excreted in feces and urine.
The action of Clopixol Depot and Clopixol-Acupaz is longer compared to oral forms.
Zuclopenthixol decanoate has a dosage-dependent sedative zuclopenthixol acetate injections or zuclopenthixol the likelihood of sedation decreases. Habituation develops quickly.
Zuclopenthixol decanoate breaks down when ingested. The maximum content of the drug in the blood serum is observed at the end of the first week. Half-life is 3 weeks. The equilibrium concentration upon repeated administration is established within 3 months.
High degree of binding to plasma proteins when administered by injection. To a small extent, their active substances cross the placental barrier . A small amount is excreted into breast milk. Excreted in feces and urine.
Clopixol tablets (zuclopenthixol hydrochloride) - oral form
This form of the drug has a much longer history of use than Clopixol Akufaz and is widely used throughout the world for the treatment of schizophrenia and other mental illnesses.
To date, a large amount of information has been accumulated on the experience of using zuclopenthixol tablets in the treatment of acute psychoses, exacerbations of chronic psychoses and acute manic states. Many direct and comparative, including double-blind, tests of this drug have been carried out, confirming its high therapeutic effectiveness, comparable to the effectiveness of haloperidol and chlorpromazine.
In the UK, a multicentre study compared, using a double-blind method, the effect of tablet forms of Clopixol and chlorpromazine in acute psychoses (schizophrenia and schizoaffective psychoses). The study included patients aged 18 to 65 years who began receiving Clopixol 25–150 mg/day (average 75 mg/day) or chlorpromazine 100–600 mg/day. Starting from the second week of treatment in most patients, without compromising the therapeutic effect, the daily dose of Clopixol was reduced to 50 mg. Chlorpromazine was used mainly at a dose of 600 mg/day throughout the study (10 weeks). Both drugs showed high antipsychotic activity. According to this indicator, there was a tendency towards an advantage of Clopixol, but it did not reach the level of statistical significance.
Another multicenter study compared the effects of tablet forms of Clopixol and haloperidol on acute psychosis using a double-blind method. The average daily dose of clopixol was 33.5 mg, haloperidol - 10.3 mg. Both drugs showed equally high therapeutic activity, however, patients taking Clopixol were discharged from the psychiatric hospital earlier, which reflected the more rapid development of the antipsychotic effect of Clopixol compared to haloperidol. Clopixol caused a significantly more pronounced reduction in the anxiety-depressive component of psychosis than haloperidol. In addition, extrapyramidal symptoms in those taking Clopixol were, as a rule, transient, while in patients receiving haloperidol they were almost permanent.
Significant improvement while taking Clopixol tablets was observed in 69 - 87% of patients with acute and subacute manic conditions. A significant reduction in the acute manifestations of manic disorder was observed according to various data during the first 1 to 4 weeks of therapy. In some studies, in some of the most severe cases, treatment of the acute condition began with the use of Clopixol Acufase for the first 3 to 6 days of treatment, and then continued with Clopixol tablets. It is important to note that the use of high doses (up to 130 - 150 mg/day) was not more effective than the use of medium therapeutic doses for mania (20 - 50 mg/day). About 80% of patients received the drug at a dose of 20 - 30 mg/day, and increasing the dosage above 50 mg/day did not increase the effectiveness of therapy, but only led to an increase in the severity of side effects. Most researchers have concluded that, with a good therapeutic effect, dose reduction can begin on average 2 weeks after the start of treatment without the risk of exacerbation. It has been suggested that the treatment of mania requires slightly lower doses than for the treatment of schizophrenia.
The use of Clopixol for agitation and aggressiveness in the elderly is of particular interest. Clopixol was compared in a double-blind manner with thioridazine and the combination of haloperidol and levomepromazine. Both studies were conducted in Scandinavia and were multicenter. The first of them included inpatient dementia patients (mainly with Alzheimer's disease) aged 64 to 97 years. Their mental state was characterized by “the presence of restlessness, hostility, as well as accompanying anxiety, confusion, irritability, insomnia, delusions, hallucinations, hypochondria, and screams.” A higher effectiveness of Clopixol on insomnia was found (the difference between the drugs is statistically significant). Side effects of Clopixol occurred rarely, their severity was insignificant, and no serious adverse effects on the cardiovascular system associated with the drug were observed.
A patient population similar in demographic and clinical characteristics was used to compare Clopixol tablets with a combination of haloperidol and levomepromazine (tizercin, nozinan). The study lasted 4 weeks. The starting dose for Clopixol was 4 mg (one 2 mg tablet twice a day). In another group of patients, 1 mg of haloperidol was prescribed in the morning and 5 mg of levomepromazine in the evening. The average daily drug doses at the end of the study were slightly higher: 4.8 mg clopixol; 1.6 mg haloperidol + 7.6 mg levomepromazine. The authors concluded that for the treatment of aggression and agitation in the elderly, it is preferable to use Clopixol tablets because it acts faster and allows monotherapy.
It should be noted that, in accordance with the average dosages used for a particular mental pathology, tablets of different dosages are produced: 2, 10 and 25 mg, which makes the use of the drug more convenient.
Thus, literature data indicate that Clopixol tablets can be successfully used both in the treatment of acute and subacute psychoses, including acute manic states, and in the treatment of agitation and aggressiveness in the elderly, as well as for the correction of behavioral disorders in persons with intellectual disabilities .
Indications for use
The drug is prescribed for chronic and acute forms of schizophrenia , as well as other psychotic disorders accompanied by hallucinations , disturbances in thinking, and paranoia. In addition, it is prescribed to eliminate the state of agitation , hostility, manic phase of manic-depressive psychosis , increased anxiety, aggressiveness, mental retardation in combination with psychomotor agitation and other behavioral disorders. The drug is also used for senile dementia , accompanied by paranoid ideas, behavioral disturbances, disorientation, and confusion.
Clopixol Depot provides continuous treatment. Its active substance prevents the occurrence of relapses that may occur due to interruption in taking the pills.
Clopixol-Acupaz is used to treat acute psychoses , chronic psychoses during exacerbations and manic states.
Indications and restrictions for taking Clopixol
Zuclopenthixol is prescribed for various human mental disorders that are accompanied by productive symptoms, cognitive impairment, thinking disorders and motor agitation:
- manic episode;
- aggressiveness, including physical;
- psychosis of inorganic nature;
- schizophrenia (simple, hebephrenic, paranoid, paranoid);
- hallucinations;
- agitation (motor restlessness with pronounced emotional arousal);
- alcoholic psychosis;
- dementia of unknown origin;
Dementia - disturbances of orientation in space and time;
- bipolar circulatory disorder (circulatory disease);
- chronic and acute psychotic disorders;
- withdrawal disorders accompanied by delirium;
- mental fatigue;
- behavioral disorders.
The drug is not prescribed for comatose states and acute intoxication with barbiturates, alcohol or opioid analgesics. The drug is also contraindicated for pregnant women.
In pregnant women, Clopixol is able to penetrate the placental barrier; in nursing women, it is excreted in breast milk, but in small quantities (about 1% of the initial dosage). So the use of the drug in this case depends entirely on the psychiatrist’s tactics and the severity of the psychosis.
Use during the third trimester of pregnancy can cause extrapyramidal disorders - neuroleptic parkinsonism, neuroleptic malignant syndrome, acute dystonia, tardive dyskinesia and akathisia (undetectable need for movement).
There is evidence of an effect on the reproductive capacity of both women and men: erectile dysfunction, amenorrhea, galactorrhea and hyperprolactinemia may occur. There are no clinical data on the use of the drug in childhood, so administration to children is strictly not recommended.
Contraindications
This drug is contraindicated in acute alcohol intoxication , as well as acute intoxication with opioid analgesics and barbiturates , coma , hypersensitivity to the components of the drug.
In addition, it is not advisable to prescribe it during pregnancy and lactation .
Contraindications and precautions
The drug has few contraindications. The drug is not used for various intoxications - alcohol, poisoning with barbiturates, morphine, and other narcotic drugs.
They enhance the neuroleptic effect of zuclopenthixol and its side effects. At the same time, the toxic effect of ethanol, barbiturates, and opiates on liver cells increases.
When using Clopixol Depot, there is a possibility of developing a malignant form of neuroleptic syndrome. A fatal outcome in this case is possible in patients with organic brain damage, alcohol and other intoxication.
The drug should be used with extreme caution for liver diseases. Zuclopenthixol affects glucose tolerance and may change the need for insulin. It is not advisable to prescribe an antipsychotic for a history of arrhythmias of various origins, or a heart attack in the recent past.
The drug is not prescribed to patients with age-related dementia. Using the drug increases the risk of death. The mechanism of this phenomenon has not been studied.
Cross-drug interactions
It is forbidden to mix Clopixol Depot with drugs containing sesame oil, as this changes their properties.
Zuclopenthixol enhances the toxic properties of alcohol. When taken simultaneously with drugs that lower blood pressure, it reduces the effectiveness of the latter.
The drug is not used simultaneously with metoclopramide, piperazine. Zuclopenthixol increases lithium toxicity. During treatment with a neuroleptic, it is undesirable to prescribe diuretics, as they increase the concentration of the active component in the blood.
Side effects
When taking the medicine, as a rule, the following side effects may occur:
- Nervous system: dizziness , the appearance of extrapyramidal disorders (for their disappearance, you can reduce the dose or take antiparkinsonian drugs), drowsiness , disturbance of accommodation dyskinesia , akathisia , hypokinesia , hyperkinesia , tremor , hypertonicity , headache , disturbances of attention and gait are possible dystonia , paresthesia , amnesia , syncope , speech disorders, convulsions, hyperreflexia , parkinsonism , ataxia , hypotonia , migraine , sleep disturbance , anxiety, pathological and nightmare dreams, depression , nervousness, apathy , confusion .
- Digestive system: dry mouth, constipation , increased salivation, vomiting, diarrhea , dyspepsia , abdominal pain, flatulence , nausea.
- CVS: arterial hypotension , orthostatic hypotension , tachycardia .
- Visual system: visual impairment, mydriasis .
- Respiratory system: stuffy nose, shortness of breath .
- Hearing organs: hypersensitivity, ringing in the ears.
- Skin: hyperhidrosis , itching , dermatitis , rash, photosensitivity, pigmentation disorder, seborrhea , purpura .
- Musculoskeletal system: myalgia , muscle rigidity , torticollis , trismus .
- Metabolic processes: increased or decreased appetite , weight gain or loss.
- Urinary system: urinary retention, urinary disorders, polyuria .
- Liver and biliary system: violation of functional tests.
- Reproductive system: lack of ejaculation, orgasmic disorders (women), erectile dysfunction , decreased/increased libido, dry vulvovaginal area.
- General disorders: asthenia , malaise, fatigue, pain, thirst, pyrexia , hypothermia .
In rare cases it is possible:
- Digestive system: transient changes in liver tests.
- CVS: venous thromboembolism , prolongation of the QT on the ECG .
- Hematopoietic and lymphatic system: thrombocytopenia , leukopenia , neutropenia , agranulocytosis .
- Endocrine system: increased prolactin .
- Metabolic processes: hyperglycemia , hyperlipidemia , problems with glucose tolerance.
- Immune system: hypersensitivity reactions, anaphylactic reactions.
- Reproductive system and mammary glands: gynecomastia , amenorrhea , galactorrhea , priapism .
- Liver and biliary system: cholestatic hepatitis , jaundice .
- Nervous system: neuroleptic malignant syndrome .
Side effects are generally dose dependent. They may be more pronounced at the beginning of treatment and gradually decrease.
The consequences of using the drug by pregnant women and during breastfeeding have not been thoroughly studied.
An unexpected interruption of treatment may cause withdrawal symptoms. As a rule, these are dizziness , nausea, anorexia, rhinorrhea , myalgia , insomnia , agitation, vomiting, diarrhea , increased sweating , paresthesia , restlessness , tremor , anxiety, alternating sensations of heat or cold.
These symptoms may appear within 1-4 days after stopping the drug and gradually decrease over 1-2 weeks.
Side effects and overdose
Unpleasant symptoms associated with taking Clopixol Depot appear at the initial stage of treatment. The severity of symptoms depends on the dosage of the drug. After adjustment of prescriptions, the risk of side effects decreases.
If unpleasant symptoms appear, you should contact your doctor and reconsider the dosage and interval between doses of zuclopenthixol; it is possible to prescribe other drugs from this pharmaceutical group.
Patients complained of the following side effects:
- The appearance of extrapyramidal symptoms. They are treated with drugs used for Parkinson's disease. They should not be used prophylactically.
- Dyskinesia is not relieved by antiparkinsonian drugs.
- Drowsiness, lethargy.
- Dry mouth, dizziness, urinary retention, trembling limbs.
- Changes in heart rhythm.
- Slight change in the amount of liver transaminases.
- Pathologies of the circulatory system rarely develop while taking the drug.
Abrupt withdrawal from zuclopenthixol therapy causes withdrawal syndrome. This condition is accompanied by nausea, vomiting, defecation disorders, insomnia, and increasing anxiety.
An overdose is unlikely, since the administration of the drug requires certain skills and is carried out at a medical institution.
Against the background of excessive administration of the drug, the following is observed:
- Drowsiness
- Coma, shock
- Increased extrapyramidal symptoms
- Convulsions
- Decreased body temperature
- Cardiac arrhythmia.
There is no specific antidote. Treatment is symptomatic. Particular attention should be paid to normalizing spontaneous breathing.
Instructions for use of Clopixol (Method and dosage)
The tablets are taken orally in several doses. The first doses of the drug should be small, then they are gradually increased taking into account the patient's response to the course of treatment.
In the case of an acute attack of schizophrenia and other acute psychotic illnesses, manic states, severe agitation , the instructions for use of Clopixol recommend a daily dosage of 10-50 mg.
For patients with chronic schizophrenia and other chronic psychoses, the dosage per day is 20-40 mg.
For senile disorders, which are accompanied by agitation and confusion , the medicine is taken 2-6 mg per day; if necessary, the dose can be increased to 10-20 mg. It is advisable to take the tablets in the evening.
For moderate to severe psychotic illnesses, the initial dosage is 20 mg per day. It can be gradually increased every 2-3 days by 10-20 mg until the daily dose reaches 75 mg.
For agitation in the case of oligophrenia, the daily dosage is 6-20 mg. If necessary, it is increased to 25-40 mg.
After using Clopixol-Acupaz injections, Clopixol tablets are prescribed 2-3 days later.
The instructions for Clopixol Depot and Clopixol-Acufaz indicate that their dosages are selected individually, taking into account the patient’s condition. Intramuscular injections. Medicines are injected into the upper outer quadrant of the buttock.
As a rule, 1–3 ml of Clopixol-Acufaz is prescribed. If more than 2 ml is administered, the dose is divided into two times, injected into different places. If necessary, a second injection is given after 2-3 days. In some cases it is prescribed after 1-2 days.
Zuclopenthixol acetate should not be used for a long time. Maximum – 2 weeks. During the entire period of treatment, the dosage should not exceed 400 mg, and the number of injections should not exceed 4.
Maintenance therapy continues with tablets or injections of Clopixol Depot. The transition is carried out according to the following scheme:
- For therapy with tablets with zuclopenthixol : 2-3 days after the last injection, a dose of 40 mg is prescribed. It is recommended to divide it into several times. If necessary, the dosage can be increased by 10-20 mg every 2-3 days up to 75 mg.
- For therapy with Clopixol Depot: after the last injection of zuclopenthixol acetate, inject 1-2 ml of zuclopenthixol decanoate . Intramuscular injections of the latter continue every 2-4 weeks. If necessary, you can use higher dosages or do shorter intervals between injections.
In addition, Clopixol Depot and Clopixol-Acufaz can be mixed in one syringe and given as one injection. zuclopenthixol decanoate then determined on an individual basis.
For elderly patients, doses may be reduced. The maximum single dosage should not be more than 100 mg.
A drug containing zuclopenthixol decanoate may cause irritation at the injection site. Injections in a dosage of more than 2 ml are divided into two doses.
Switching from a course of tablets to Clopixol Depot injections:
- The usual daily oral dosage, increased by 8 times, is equal to one injection of zuclopenthixol decanoate every 2 weeks.
- The usual daily oral dosage, increased by 16 times, is equal to one injection of zuclopenthixol decanoate every 4 weeks.
After the first injection, the tablets are continued to be taken for a week, but in a smaller dosage.
Elderly patients are prescribed Clopixol Depot in a minimal dose.
If there are problems with liver function, half the usual injection dosage is prescribed and the content of the drug in the blood serum is monitored.
Analogs
The list of drugs in the Neuroleptics group is quite extensive. But there are few drugs in injection form. The pharmacist will offer the following analogues of Clopixol:
Clopixol-Acufaz
Made in Denmark. The active dosage is 50 mg per 1 ml of solution.
The cost of a package of 10 ampoules is 2 thousand UAH. in Ukraine and the Russian Federation - about 300 rubles.
Pros:
- Also active ingredient
- Similar action.
Minuses:
- Dose – re-administration required after 48 hours
- The drug is not intended for long-term treatment
- The price is higher than that of Clopixol Depot, despite the lower dosage
- Side effects.
Fluanxol Depot
Produced in Denmark.
The main active ingredient is flupenthixol at a dosage of 20 mg/1 ml.
The cost of a package of 10 ampoules for residents of Ukraine is 900 UAH. In the Russian Federation – 2200 rubles.
Pros:
- The price is lower than that of Clopixol Depot and Clopixol-Acufaz.
- Interval between injections – 2–4 weeks
- Similar action.
Minuses:
- Similar side effects.
Neuroleptics are heavy drugs for the treatment of complex mental disorders. Therefore, changing your doctor’s orders on your own is inappropriate.
Overdose
Manifestations of drug overdose in all forms: drowsiness, extrapyramidal disorders , arterial hypotension , hyperthermia , coma , convulsions, shock, hypothermia .
Gastric lavage is prescribed as therapy. Then treatment is symptomatic. Maintenance therapy is carried out. Adrenaline should not be used . Seizures can be prevented with Diazepam , and extrapyramidal symptoms with Biperiden .
An overdose of the drug by injection is considered unlikely. ECG changes and QT prolongation , and Torsade de Pointes arrhythmias ventricular arrhythmias , and cardiac arrest have also been reported.
Therapy in this case is symptomatic and supportive. It is necessary to take measures to improve the functions of the respiratory system and cardiovascular system.
Interaction
This medicine may increase the sedative effect of nervous system depressants. It should not be prescribed together with Guanethidine and its analogues, as well as with medications that significantly prolong the QT interval . of adrenergic may be reduced when used simultaneously. extrapyramidal symptoms increases when combined with Metoclopramide and Piperazine .
Together with lithium preparations, the likelihood of neurotoxicity .
Tricyclic antidepressants, when combined with antipsychotics, mutually suppress biotransformation.
The use of drugs that inhibit the CYP2D6 enzyme will slow down the elimination of zuclopenthixol .
Use this drug with caution with drugs that affect electrolyte balance.
Reviews of Clopixol
As a rule, patients leave reviews about Clopixol in the form of an injection solution. They note that the course of use of this drug is very convenient, since injections are rarely given. It's much easier than constantly taking pills.
However, some advantages of this medicine are also noted in the tablet form. For example, the fact that you don’t need to go to the doctor. The patient takes the medicine on his own, so there is no need to coordinate his plans with the injection schedule.
Reviews of Clopixol Depot and a similar drug in tablet form also note some undesirable effects. Typically, patients report apathy and decreased libido. Extrapyramidal disorders are sometimes described .
However, there is no doubt about the effectiveness of this remedy. The main thing is to take it strictly as prescribed by your doctor. For any dose adjustments or changes in condition, you should definitely contact a specialist.
Similar drugs:
- Eglonil Oral tablets
- Finlepsin Oral tablets
- Moditen depo Solution for intramuscular administration
- Egolanza Oral tablets
- Rispaksol Oral tablets
- Thiodazine Oral tablets
- Closasten (Closastene) Oral tablets
- Thioridazine Oral tablets
- Leponex Oral tablets
- Risperidone Oral tablets
** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Clopixol Depot, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Clopixol Depot is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Clopixol price, where to buy
The cost of this medicine depends on the form of release. The average price of Clopixol tablets is as follows:
- 2 mg tablets 50 pieces – 240 rubles;
- tablets 25 mg 100 pieces – 1550 rubles;
- tablets 10 mg 50 pieces – 460 rubles.
The cost of Clopixol-Acufaz is approximately 2100 rubles.
The price of Clopixol Depot for one ampoule per package is about 370 rubles, for 10 ampoules per package – 3200 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Clopixol depot solution for intramuscular injection.
oil 200mg/ml 1mlLundbeck RUB 223 order - Clopixol depot solution for intramuscular injection. oil 200mg/ml 1ml 10 pcs.Lundbeck
RUR 2,022 order
- Clopixol tablets p.p.o. 10mg 50 pcs Lundbeck
RUB 277 order
- Clopixol tablets p.p.o. 2mg 50 pcs.Lundbeck
65 rub. order
- Clopixol-acufase solution for intramuscular injection. oil 50mg/ml 1ml 5 pcs.Lundbeck
RUB 1,409 order
Pharmacy Dialogue
- Clopixol (2 mg tablet No. 50) Lundbeck
240 rub. order
- Clopixol Depot (amp. 200 mg/ml 1 ml No. 1) Lundbeck
RUR 384 order
- Clopixol Depot (amp. 200 mg/1 ml No. 10) Lundbeck
RUB 2,058 order
- Clopixol (tab. 10 mg No. 50) Lundbeck
RUB 292 order
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Pharmacy24
- Clopixol 2 mg No. 100 tablets H. Lundbeck A/S, Denmark
216 UAH order - Clopixol-depot 200 mg 1 ml N10 solution for injection H. Lundbeck A/S, Denmark
1412 UAH order
- Clopixol 10 mg No. 100 tablets H. Lundbeck A/S, Denmark
344 UAH. order
- Clopixol-Acufase 50 mg 1 ml N10 solution for injection H. Lundbeck A/S, Denmark
1930 UAH order
Composition and release forms
The main component of the drug is zuclopenthixol. Other substances - triglycerides - are auxiliary.
In appearance, Clopixol Depot is a transparent oily solution. It may have a yellowish tint, which is not a sign of spoilage. The drug is available in 2 dosages - 200 and 500 mg of the active substance. The ampoules contain 1 ml of solution. Packaged in cardboard boxes of 10 pcs.
There is a separate drug called “Clopixol tablets”, coated. They do not have a prolonged effect. The drug is released in 3 dosages. Tablets are packed in a plastic container of 100 pcs.
Description of the appearance of the Clopisol tablet depending on the dose:
- 2 mg – pale red shell
- 10 mg – light red-brown
- 25 mg – rich red-brown shell.
