pharmachologic effect
A medicine that replenishes the lack of magnesium and vitamin B6 in the body.
Magnesium is vital for the human body. Takes part in metabolic processes and is necessary for the full functioning of cells. A third of magnesium in the body is deposited in bone tissue.
The trace element regulates neuromuscular transmission and is necessary for muscle contraction. It is not produced independently, intake is possible only from the outside with food and vitamin complexes. Mg deficiency is observed with an unbalanced diet, diet, or increased need for the microelement.
Pyridoxine hydrochloride improves the absorption of Mg from the lumen of the digestive tract and promotes penetration into the cell.
Vitamin B6 is required for the normal course of metabolic reactions and processes. Registration of less than 12 mg/l magnesium in the serum indicates a pronounced, severe form of Mg deficiency.
Effect of drugs
Both drugs provide the body with magnesium, an element very important for normal functioning. All tissues of the body need it, cells naturally function with its help, and magnesium is indispensable for metabolism. Thanks to this element in the body:
- protein synthesis is normal,
- muscles contract (vital for the heart),
- blood vessels dilate,
- the propagation of impulses is regulated in nerve fibers.
- bile secretion is stimulated,
- motor activity of the digestive tract improves,
- stimulates the elimination of excess cholesterol.
The drug helps:
- prevent the occurrence of atherosclerosis,
- reduces the possibility of complications from diabetes,
- reduces nervous tension.
A lack of magnesium can cause problems in the body. Therefore, it is so important to compensate for its deficiency while expecting a child, during heavy physical exertion and active brain activity, a poor diet and some diseases with impaired absorption of microelements.
Vitamin B6 contained in Magna B6 makes the absorption and distribution of magnesium within cells more active. In addition, pyridoxine stimulates brain function, improves memory and emotional state of a person, accelerating the metabolic process in tissues.
Problems that vitamin B6 in combination with magnesium help solve:
- Constipation (intestinal function improves significantly, especially if taken in combination with vitamin C and drink more water);
- Increased pressure (vessels dilate according to normal);
- Osteoporosis (magnesium normalizes calcium metabolism);
- Depression (decreased serotonin levels in the brain - a consequence of magnesium deficiency);
- Premenstrual syndrome (taking magnesium helps avoid unpleasant symptoms such as bloating and weight gain, swelling, breast tenderness, insomnia);
- Eclampsia (this is a form of late toxicosis of pregnancy, when the expectant mother’s blood pressure rises sharply, which can lead to convulsions with loss of consciousness and is dangerous for the life of the mother and child. Prophylactic intake of magnesium helps prevent such conditions).
Contraindications
- simultaneous therapy with Levodopa ;
- severe kidney pathology (creatinine clearance below 30 ml/min);
- individual hypersensitivity;
- lactase deficiency (hereditary form);
- galactose and glucose malabsorption syndrome (hereditary form);
- galactosemia (hereditary form);
- age limit – up to 6 years;
- phenylketonuria.
A relative contraindication for the use of Magne B6 Forte is moderate renal failure due to the risk of hypermagnesemia.
Magne B6 Forte, instructions for use (Method and dosage)
The tablets should not be broken and the integrity of the film shell should not be damaged, which may negatively affect the absorption of the active components. Take enough liquid.
Instructions for Magne B6 Forte for adults
During meals, in 2-3 doses, 3-4 tablets per day.
For children
Weighing more than 20 kg and older than 6 years: the initial dose is calculated according to the following scheme: 10-30 mg/kg/day, which corresponds to 2-4 tablets. Take with meals, 2-3 doses per day. The duration of vitamin therapy is about 1 month.
Forms of release and varieties of Magne B6
The differences between Magne B6 and Magne B6 Forte are in the number of active ingredients. In the product with the prefix “Forte” there are exactly twice as many of them.
"Magne B6" exists in 2 forms, which must be selected based on the age and condition of the patient: in tablets or in a solution, which is also taken orally; "Magne B6 Forte" is available in only one version - tablets.
Pills
The tablets look like this: white with a smooth surface, oval in shape, with equally convex sides. "Magne B6" is produced in packages containing blisters with 50 tablets (10 in each), in a box with "Magne B6 Forte" - 30 (2 blisters of 15 pieces) or 60 (4 such blisters) tablets.
Tablets are stored for no more than 2 years from the date of release in a dark place with low humidity. Storage temperature – up to 25 degrees.
Ampoules
The Magne B6 package contains dark glass 10 ml ampoules (10 pcs.) of a brown solution that smells like caramel.
The shelf life of the solution is higher than that of tablets for a whole year, while they have absolutely the same storage conditions and temperature.
Overdose of Magne B6 Forte
Taking large doses of magnesium with normal functioning of the renal system does not cause toxic manifestations. Magnesium poisoning has been reported in patients with kidney disease. The clinical picture depends on the amount of Mg. Symptoms:
- respiratory depression;
- ECG changes, decreased reflexes;
- depression of the nervous system;
- nausea;
- drop in blood pressure ;
- respiratory paralysis;
- vomit;
- anuric syndrome;
- cardiac arrest.
Timely implementation of procedures for rehydration and forced diuresis . Peritoneal dialysis and hemodialysis are effective for severe pathology of the renal system.
Overdose and side effects
Overdose usually does not occur if the kidneys are functioning normally. In kidney failure, this can occur and lead to magnesium poisoning. The consequences and signs of an overdose can be very serious - from nausea and vomiting to coma. In particular they can:
- The central nervous system is depressed;
- Decreased blood pressure;
- Reflexes decrease;
- Respiration is depressed;
- Do not pass urine;
- The work of the heart is disrupted until it stops.
In such conditions, it is necessary to resort to peritoneal or hemodialysis. At the first sign of overdose, the person should be given plenty of water and diuretics, as well as oral rehydration solutions.
Although the drug is well tolerated in people with normally functioning kidneys, it can sometimes lead to side effects:
- Various allergic reactions;
- Constipation or vice versa - diarrhea, or bloating;
- Nausea with vomiting;
- Pain in the abdominal area;
- Numbness of the limbs (very rare, with long-term use of large doses).
Interaction
Invalid combinations
Pyridoxine hydrochloride inhibits the activity of Levodopa (in the absence of adequate supply of amino acid decarboxylase inhibitors).
Possible but not recommended combinations
The absorption of Magnesium from the intestinal lumen slows down when taking medications that contain calcium salts or phosphates.
Combinations that require attention
Magnesium reduces the absorption of Tetracycline . The time interval between taking tetracycline antibiotics and Magne B6 is 3 hours or more.
Indications and contraindications
According to the instructions for use, Magne B6 and Magne B6 Forte are prescribed in the following situations:
- With magnesium deficiency. Characteristic symptoms indicating a possible deficiency of the element in the body: fatigue and irritability, rapid heartbeat, disturbed sleep, spastic contractions in the digestive tract and muscles.
- To prevent magnesium deficiency. This need can be caused by pregnancy, stress, malnutrition, and taking diuretics (urine removes magnesium).
Taking any form of the drug is contraindicated in the following situations:
- If the patient has renal failure (especially its severe forms);
- For fructose intolerance;
- If there is not enough sucrose-isomaltase in the body;
- For patients with phenylketonuria;
- In case of individual intolerance to any components of the drug;
- If a person takes Levodopa.
According to the instructions for use, Magne B6 and Magne B6 Forte are prescribed in the following situations:
- With magnesium deficiency. Characteristic symptoms indicating a possible deficiency of the element in the body: fatigue and irritability, rapid heartbeat, disturbed sleep, spastic contractions in the digestive tract and muscles.
- To prevent magnesium deficiency. This need can be caused by pregnancy, stress, malnutrition, and taking diuretics (urine removes magnesium).
Taking any form of the drug is contraindicated in the following situations:
- If the patient has renal failure (especially its severe forms);
- For fructose intolerance;
- If there is not enough sucrose-isomaltase in the body;
- For patients with phenylketonuria;
- In case of individual intolerance to any components of the drug;
- If a person takes Levodopa.
special instructions
The tablet form is intended only for persons over 6 years of age. Use with caution in case of pathology of the renal system due to the risk of hypermagnesemia .
Patients with a deficiency of magnesium and calcium first of all need to compensate for the Mg deficiency, and only then start taking calcium-containing nutritional supplements and medications.
Long-term use of pyridoxine hydrochloride in large quantities (more than 200 mg per day) can provoke axonal sensory neuropathy , which is manifested by ataxia, limb tremor , impaired proprioceptive sensitivity, and numbness.
The above symptoms are reversible and go away on their own when the medication is discontinued.
Analogs
Level 4 ATX code matches:
Magwit
Magne B6
Vitrum Life
Analogs containing magnesium:
- Complivit Magnesium;
- Doppelhertz Active;
- Magnelis B6;
- Panangin;
- Magnesium Plus.
Reviews of Magne B6 Forte
The drug is often prescribed to pregnant women to replenish the lack of magnesium in the body.
Patients note a significant improvement in their well-being during vitamin therapy: sleep improves, nervousness and overexcitation go away, and heart rate normalizes.
Reviews about the drug, both from doctors and patients, are extremely positive.
The medication is easily tolerated without causing pronounced negative reactions.
Reviews from doctors
Doctors speak positively about the drug. Taking it leads to stabilization of magnesium levels in the body, which is confirmed by tests. Most doctors note that patients with functional cardialgia, as well as those suffering from neurocirculatory dystonia, significantly improved their condition after a course of Magne B6 therapy.
The product effectively helps to get rid of excessive irritability, relieves nervousness and signs of fatigue, and increases the body's resistance to stress.
Gynecologists report that taking Magne B6 will help stabilize blood pressure in pregnant women, help relieve uterine hypertonicity and prevent miscarriage. Cardiologists and therapists say that most patients with complaints of chest pain, rapid heartbeat and sudden changes in blood pressure noted the disappearance of these symptoms after a course of drug therapy.
When Magne B6 was prescribed to children, improvement in sleep and normalization of the process of falling asleep were noticed. Children cry and act up less, and become more attentive and calm. Magne B6 Forte, when following the instructions for use in adolescents, reduces nervousness, helps to better assimilate information and, moreover, helps stabilize weight.
Despite all the positive aspects of the drug, taking it independently without a doctor’s prescription can provoke reactions that are completely opposite to those expected. Only a specialist can identify magnesium deficiency and choose the correct treatment and required dosage.
