Protozoan parasites are found in the body of almost every person and often do not manifest themselves in any way, but at any time they can go into the acute phase, with a decrease in immunity due to illness and seasonal vitamin deficiency.
There are mites of the glandular acne type, which are located on the skin of a person’s face and in the follicles of the eyelashes. Infestation by these parasites is called demodicosis.
They can cause acne to appear on the face and back, and if the infection worsens in the eye area, you may experience persistent itching of the eyelids and thick mucous discharge. And these are just the initial symptoms. If treatment for this type of parasite is not carried out, the patient will experience severe eye pain.
The current choice on the pharmacological market allows you to get rid of acne without much difficulty. Metronidazole drops effectively fight this disease. Below we will discuss the disease demodicosis itself and methods of treating it with drugs based on metronidazole.
What is the composition and action?
The main substance of the drug is metronidazole. It has antimicrobial and antiprotozoal properties. A synthetic component that is effective against a number of anaerobic, gram-positive and protozoan microorganisms. Once on tissue, it inhibits the synthesis of pathogenic microflora, depriving them of nucleic acids, which leads to the death of bacilli. Available in the following types:
- pills;
- solution for infusion;
- powder;
- candles;
- ointments;
- cream;
- gel.
When used locally, it is practically not absorbed into the bloodstream. In the form of a gel or cream, it is used as a remedy for the treatment of ocular demodicosis. In addition to the main active ingredient, Metronidazole for topical use includes substances such as:
One of the components of the drug is water.
- water;
- sodium salt;
- nipagin;
- propanediol;
- propanetriol.
Getting rid of eyelash mites
Taking into account the life cycle of the eyelash mite, treatment for demodicosis should last at least 45 days. This parasitic infestation must be gotten rid of with the help of complex medical therapy and properly selected nutrition, which can restore normal functioning of the gastrointestinal tract and improve immunity.
Both for prevention and during treatment, you need to wash your face with tar soap, which has antiseptic properties, and regularly massage your eyelids (at least twice a day). It facilitates the removal of toxic substances that have accumulated in the glands.
To reduce the activity of mites, treat the edges of the eyelids with an alcohol tincture based on eucalyptus or calendula twice a day. During an exacerbation of demodicosis, it is necessary to iron all bed linen and towels; the patient is prohibited from using someone else’s towel and bed linen set. This is necessary to avoid infecting other family members.
During treatment, the ophthalmologist prescribes drugs for oral administration, for example Trichopolum, the action of which is aimed at the death of protozoan parasites. In case of severe allergic reactions caused by toxic waste products of demodex, taking antihistamines (Suprastin, Loratadine) is indicated.
Well, to relieve painful eye symptoms and kill eyelash mites directly at the site of localization, metronidazole-based gels, such as Metrogyl, are widely used. They have antimicrobial properties even against those parasites that can exist without oxygen, and stimulate regenerative processes. Next, the price of the drug, reviews and analogues will be presented.
The average price of Metrogyl gel in the Russian Federation ranges from 185 to 215 rubles. it has analogues, such as:
- Rosex cream (545 rub.);
- Rozamet (245 rubles).
The above analogues do not differ from Metrogyl gel either in the active substance or in the pharmacological properties. So their use is impractical due to their higher cost.
For acute illness, you need to use metronidazole-based creams and gels twice a day for two weeks, then make an interval of three weeks, and finish the course with another two weeks of using the drug.
Apply only to the outer part of the eyelid. Below are detailed instructions for using Metrogyl gel.
Indications for use
The action of Metronidazole is extensive. According to oncologists, the drug can be used even in the treatment of tumors. It is used externally, internally and vaginally. According to oncologists, the drug can be used even in the treatment of tumors. For the prevention and treatment of eyes, it is prescribed topically for the following ailments:
- demodicosis;
- trichomoniasis;
- giardiasis;
- amoebiasis;
- keratitis;
- toxoplasmosis;
- blepharoconjunctivitis;
- giardiasis;
- cutaneous leishmaniasis;
- pathologies caused by anaerobic microorganisms;
- sepsis.
It is necessary to use Metronidazole for the eyes with caution so that the medicine does not get on the mucous membrane. If this happens, rinse thoroughly with water. To enhance the effect, it is necessary to use antimicrobial eye drops.
Instructions for use METRONIDAZOLE tablets
To avoid the development of resistance of microorganisms, metronidazole should only be used to treat infections caused by metronidazole-sensitive strains (according to microbiological examination of the material or epidemiological data).
Trichomoniasis with clinical symptoms.
Metronidazole is indicated for the treatment of trichomoniasis with clinical symptoms in women and men, if the presence of trichomonas has been confirmed by appropriate laboratory tests (smear and/or culture).
Asymptomatic trichomoniasis.
Metronidazole is indicated for the treatment of women with asymptomatic trichomoniasis (endocervicitis, cervicitis or cervical erosion). Because there is evidence that the presence of trichomonas may interfere with the accurate evaluation of cytological smears, additional smears should be performed after eradication of the parasite.
Treatment of a spouse without clinical manifestations.
T. vaginalis infection is a sexually transmitted disease. Thus, asymptomatic sexual partners should be treated at the same time to prevent reinfection from the partner, even if the pathogen is not isolated. The decision about whether to treat an asymptomatic male partner in whom trichomonas is not detected, or where testing has not been performed, is an individual one. In making this decision, it should be noted that there is evidence that a woman can become infected again if her husband is not treated. In addition, because there are significant difficulties in isolating the pathogen from an asymptomatic patient, negative smear and culture results should not be relied upon. In any case, in case of re-infection, the spouses should be treated with metronidazole at the same time.
Amoebiasis.
Metronidazole is indicated for the treatment of acute intestinal amebiasis (amebic dysentery) and liver abscess caused by amoebae. When treating a liver abscess caused by amoebas with metronidazole, the need for aspiration or drainage of pus cannot be excluded.
Anaerobic bacterial infections.
Metronidazole is indicated for the treatment of severe infections caused by susceptible anaerobic bacteria. Necessary surgical procedures must be performed in combination with metronidazole therapy. In case of mixed aerobic and anaerobic infection, appropriate antimicrobial agents should be used in addition to metronidazole. When treating severe anaerobic infections, metronidazole is usually given first. Intra-abdominal infections, including peritonitis, intra-abdominal abscess and liver abscess, are caused by Bacteroides, including the B. fragilis group (B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Clostridium, Eubacterium, Peptococcus niger and Peptostreptococcus .
Infections of the skin and skin structures,
caused by Bacteroides (including the B. fragilis group), Clostridium, Peptococcus niger, Peptostreptococcus and Fusobacterium.
Gynecological infections,
including endometritis, endomyometritis, tubo-ovarian abscess and infections after gynecological surgery caused by Bacteroides (including B. fragilis group), Clostridium, Peptococcus niger and Peptostreptococcus.
Bacterial septicemia,
caused by Bacteroides (including the B. fragilis group) and Clostridium.
Bone and joint infections
caused by Bacteroides species (including the B. fragilis group) as adjunctive therapy.
CNS infections
including meningitis and brain abscess caused by Bacteroides (including B. fragilis group).
Lower respiratory tract infections,
including pneumonia, empyema and lung abscess caused by Bacteroides (including B. fragilis group).
Endocarditis,
caused by Bacteroides (including the B. fragilis group).
Contraindications
For kidney disease, it is prohibited to use drugs with this antibiotic.
The manufacturer does not recommend the use of eye medications with metronidazole in the following situations:
- age up to 3 years;
- pregnancy and lactation;
- allergy to medication components;
- kidney and liver diseases;
- leukopenia;
- CNS lesions;
- epilepsy;
- surgical intervention at the site of application;
- open wounds.
Side effects
Occasionally, the active ingredient of the drug can provoke insomnia in the patient.
The drug is well tolerated by patients. The drug is practically not absorbed into the blood and therefore does not cause side effects, but in some cases the body may react such as:
- nausea;
- dizziness and headache;
- insomnia;
- dry mouth;
- lacrimation;
- rhinitis;
- irritability;
- lack of coordination;
- rash;
- hyperemia;
- itching;
- sensations of pain;
- loss of appetite.
Metronidazole tablets 250 mg No. 10
Side effects
Gastrointestinal disorders: epigastric pain, nausea, vomiting, diarrhea, glossitis, stomatitis, metallic taste in the mouth, decreased appetite, anorexia, dry oral mucosa, constipation, pancreatitis (reversible cases), discoloration tongue / “coated tongue” (due to the growth of fungal microflora).
Immune system disorders: angioedema, anaphylactic shock. Nervous system disorders: peripheral sensory neuropathy, headache, convulsions, dizziness, encephalopathy and subacute cerebellar syndrome (impaired coordination and synergism of movements, ataxia, dysarthria, gait disturbances, nystagmus, tremor) have been reported, which are reversible after discontinuation of metronidazole , aseptic meningitis.
Mental disorders: psychotic disorders, including confusion, hallucinations; depression, insomnia, irritability, increased excitability.
Visual disturbances: transient visual disturbances, such as diplopia, myopia, blurred contours of objects, decreased visual acuity, impaired color perception; neuropathy/optic neuritis.
Blood and lymphatic system disorders: agranulocytosis, leukopenia, neutropenia, thrombocytopenia.
Disorders of the liver and biliary tract: increased activity of liver enzymes (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase), development of cholestatic or mixed hepatitis and hepatocellular liver damage, sometimes accompanied by jaundice; In patients treated with metronidazole in combination with other antibacterial agents, cases of liver failure requiring liver transplantation have been observed.
Skin and subcutaneous tissue disorders: rash, itching, skin flushing, urticaria, pustular skin rash, Stevens-Johnson syndrome, toxic epidermal necrolysis.
Renal and urinary tract disorders: brownish-reddish coloration of urine due to the presence of a water-soluble metabolite of metronidazole in the urine, dysuria, polyuria, cystitis, urinary incontinence, candidiasis.
General disorders and disorders at the injection site: fever, nasal congestion, arthralgia, weakness (for dosage forms for oral and parenteral use), thrombophlebitis (pain, hyperemia or swelling at the injection site) (for dosage forms for parenteral use).
Laboratory and instrumental data: flattening of the T wave on the electrocardiogram.
Overdose: what will happen?
A single dose of the tablet form of the drug in a large dose will cause side effects.
When using a large dose of Metronidazole tablets, side effects may occur. When using the product externally, an overdose is almost impossible. If a negative reaction of the body to the drug appears, the use of the drug is canceled and then the patient’s condition returns to normal after a few days.
