pharmachologic effect
The composition of the drug Neurobeks includes vitamins from group B, ascorbic acid, vitamin PP, thanks to which the drug supplies the body with important coenzymes involved in the metabolism of fats, carbohydrates, and proteins.
B vitamins normalize metabolism in nerve tissues, improve the nutrition of neurons in subcortical structures and the transmission of nerve impulses
Vitamin PP activates the process of carbohydrate metabolism, blood clotting, improves vascular permeability and dilates them, reduces the amount of cholesterol, helps with diseases of the gastrointestinal tract, liver, and heart. Due to its regenerating properties, this vitamin is useful for non-healing skin lesions.
Ascorbic acid is involved in the production of collagen and steroids, accelerates tissue healing, stimulates carbohydrate metabolism, and increases blood clotting.
Overdose
The drug is taken with caution, but in case of overdose, stop taking it immediately.
Overdose symptoms:
- nervous tension, anxiety;
- rapid heartbeat, pulse;
- allergic reactions with the appearance of blisters on the skin;
- drowsiness, apathy, lack of appetite.
To alleviate the condition, gastric lavage is performed using activated carbon or suitable adsorbents.
Indications for use of Neurobex
The complex is used for polyneuritis, neuralgia, sciatica, myasthenia, paresthesia, diathesis, psoriasis, pyoderma, herpes zoster, acne, arthralgia, neurocirculatory dystonia, myalgia, eczema, neurogenic dermatitis, disorders of the nervous system of a traumatic nature, encephalopathy, asthenia, hypovitaminosis, leu savings, anemia.
Good reviews about Neurobex, which is involved in the complex treatment of alcoholism and nicotine addiction.
Also, according to the instructions, Neurobeks is prescribed for the treatment of glaucoma, neuritis of the optic and auditory nerves, degenerative changes in the retina, nerve damage caused by poisoning, peptic ulcers, hepatitis, gastroduodenitis, cirrhosis, enterocolitis, cholecystitis.
A positive effect was noticed after using the complex for myocarditis, cardiovascular failure, myocardial dystrophy, and intoxication of various origins.
Interaction
The multivitamin complex is used as part of therapy for complex diseases, so its interaction with other medications is completely justified.
The exceptions are:
- Phenobarbital (when used together leads to thiamine deficiency);
- Colchicine (reduces vitamin B12 levels);
- oral contraceptives (leads to minor metabolic disturbances;)
- antithrombotic drugs (nicotinic acid can cause bleeding);
- antiepileptic drugs (may interfere with the absorption of vitamin B 12).
Contraindications
Neurobeks according to the instructions is contraindicated in acute thromboembolism, erythrocytosis, allergies, erythremia, hypersensitivity.
Pregnant and lactating women are not recommended to take Neurobex vitamins without a doctor's prescription. There is no data on the safety of using Neurobex Neo by pregnant women.
Judging by the reviews, Neurobeks, due to the vitamin B6 included in its composition, can reduce the effect of the drug taken Levodopa, phenobarbital, phenytoin.
Incompatible with vitamin B6: Isoniazid, Thiosemicarbazone, Serine, Hydralazine.
According to the instructions, it is not advisable to combine Neurobex with medications containing aluminum
Hormonal contraceptives, alcohol, and diuretics can reduce the effectiveness of Neurobex.
The calcium pantothenate contained in Neurobex Neo can enhance the effect of cardiac glycosides and reduce the toxicity of antibiotics used in the treatment of tuberculosis.
Side effects
Neorubix Neo, the instructions for use of which indicate side effects, should be stopped immediately after the first signal.
Side effects may include:
- rapid heartbeat, it may periodically return after a lull;
- nausea and vomiting accompanied by headache;
- allergic rashes accompanied by itching are a natural reaction to intolerance to the drug.
Directions for use and doses
Take the pills after meals, orally, preferably after meals.
For preventive purposes, Neurobeks is taken according to the instructions, 1-2 tablets. three times per day for one month.
During the treatment of diseases of the nervous system, adults and children after 14 years old Neurobeks take two tablets three times a day, children 8-14 years old are given one tablet two or three times a day, children 3-8 years old. – one tablet one or two times a day. Neurobex is often prescribed for nursing and pregnant women - one tablet once or twice a day.
For the treatment of asthenia in adults and children over 14 years of age. give one tablet three times a day, for children 8-14 liters. – one tablet two times a day, for children 3-8 years old. – one tablet once a day.
Neurobex forte can only be taken by children over 14 years old and adults. For prevention, take one tablet of vitamins every day for a month. For the treatment of neurological diseases - 1-2 tablets/day. Pregnant and lactating women can take one tablet per day.
The Neurobex Neo complex can be taken once a day, one tablet for two or four weeks. For the treatment of neurological diseases, take 1-2 tablets/day.
Release form
Neorubex Neo is produced in two-color gelatin-type capsules, 30 or 60 pieces, in a blister.
There is powder inside the capsule. The capsule shell dissolves smoothly when it enters the stomach.
Side effects
On the side of the scolio-intestinal tract:
rarely – anorexia, boredom, bloating/flatulence; frequency unknown - vomiting, colic, diarrhea.
On the side of the immune system:
Rarely - allergic reactions, including erythema, hissing, itching, urticaria, dyspnea and anaphylactic reactions (including shock), anaphylaxis, fever.
From the side of the vessel:
the frequency of the unknown is the tide.
From the side of the skin and under the skin:
rarely - kropivyanka, exanthema, eczematous rash. Allergic reactions include skin manifestations and angioedema; the frequency of the unknown is chervoninnya.
On the side of the nervous system:
frequency of the unknown – headache.
On the side of the thyroid system:
the frequency is unknown - a slight increase in secretion.
Apparently, when the other components were frozen, the drug was aware of the development of the following side reactions:
On the side of the dicholic system
: bronchospasm.
On the side of the cardiovascular system
: arterial hypertension, myocardial dystrophy.
On the side of the blood: hemolysis of erythrocytes in patients with deficiency of glucose-6-phosphate dehydrogenase, impaired laryngeal blood.
On the side of the nervous system: confusion, sleep disturbance, increased restlessness, fatigue.
On the side of the scutulo-intestinal tract: dyspepsia, baking, vomiting, pain in the scutum, increased secretion of the scutulous eye, deterioration of the insular apparatus of subsluic acid and disruption of glycogen synthesis even before the onset of ductal diabetes, deterioration of the glomerular apparatus, resolution of stones in the cervix and sechovidal areas, nirkova lack of supply, change in color of the cut.
Others: hepecaluria, crystalluria, glycosuria, heat sensitivity, impaired zinc metabolism, midi, aggravation, hyperhidrosis.
When taking high doses of other components of the drug, the following side effects may occur: hyperuricemia, impaired glucose tolerance, hyperglycemia, paresthesia, blood vessels, arrhythmias, arterial hypertension nysia, erythrocytopenia, neutrophilic leukocytosis, scolio-intestinal disorders, hair loss, seborrhea, hyperpigmentation, nitric deficiency, redness, fatty liver, myalgia, myopathy, temporary increase in aspartate aminotransferase, iron phosphatase, lactate dehydrogenase, increased level of sechoic acid in the blood, rupture Enabling electrolyte balance.
Patient reviews
If we look at the reviews of people who have taken Neurobex, we can note that most often representatives of the female half of the population resort to its help.
This is due, first of all, to the desire to look beautiful: as you know, without B vitamins, skin and hair lose their elasticity, become dull and lifeless.
In addition, it is women who are prone to overly emotional manifestations of their feelings, so their nervous system needs constant support.
"Neurobeks" copes with its functions perfectly , allowing you to strengthen your nerves and, as a bonus, get beautiful skin, shiny hair and strong nails. To achieve a stable result, it is recommended to take two courses of the drug per year (30 days each).
As for tolerability, in the vast majority of cases there were no side effects or negative consequences of taking Neurobex.
In very rare cases (about 3%), mild nausea was observed, which disappeared 3-4 days after starting to take the drug.
Analogs
The vitamin complex involves taking similar medications.
If reactions to one of the components occur, you can choose another option:
- Neorubix forte. This complex contains a smaller amount of B vitamins and is supplemented with other excipients. Indications for use are less than those of Neurobix neo; it is contraindicated in pregnant women and persons under 18 years of age.
- Milgamma. A drug based on vitamins B, indicated for nervous disorders, problems with tissues and blood circulation.
- Cytoflavin. Tablets containing vitamins B, with the addition of succinic acid and inosine. Prescribed for use by patients with complex brain diseases.
- Aevit. A combined preparation containing vitamins A and E is indicated for vitamin deficiencies, to replenish iron losses by the body during bleeding of various types.
Features of good stagnation
With caution and in smaller doses, it should be prescribed for angina pectoris instead of vitamin B12.
Instead of folic acid, carefully administer the drug to patients suspected of having folate-depleted swelling.
Increased intake of ascorbic acid during the pregnancy period can lead to an increase in nitric clearance and the release of the drug, but can lead to its deficiency.
When administering high doses or in case of heavy administration of the drug, it is necessary to control the functions of the lower and lower arterial pressure, as well as the functions of the subglottic gland. Care must be taken to provide medical treatment to patients with a history of illness.
Large doses of medication should not be prescribed to patients with laryngeal hemorrhage.
Residues of ascorbic acid promote the absorption of the saliva, and when taken in high doses, it may be unsafe for patients with hemochromatosis, thalassemia, polycythemia, leukemia and sideroblastic diseases. I'm speechless. Patients with high levels of fluid in the body should be given medication in minimal doses.
Immediately drinking the medicinal solution with water drinks replaces the absorption of ascorbic acid, so it is not necessary to wash it down with mineral water. Do not take medicine with hot drinks (especially kava) or alcohol. Also, the absorption of ascorbic acid can be disrupted with intestinal dyskinesias, enteritis and achylia.
Use caution when treating patients with glucose-6-phosphate dehydrogenase deficiency.
Ascorbic acid can interfere with the results of laboratory tests, for example, when measured in conjunction with blood glucose, bilirubin, transaminase activity, and lactate dehydrogenase.
Some ascorbic acid has a slight stimulating effect; it is not recommended to stop taking the drug until the end of the day.
The drug should be taken with care for patients with cardiac diabetes, dystrophic heart disease, decompensation of cardiac function, ischemic heart disease, and illness. our hematopoietic organs, in case of scolio-intestinal illnesses, stomach illness, chronic pancreatitis, in case of liver disease, illness with gastrointestinal tract nephritis, with glaucoma, hemorrhages, arterial hypotension of the death stage.
There is a possibility of congestion in yellow colors, which is a completely unexpected factor and is explained by the presence of riboflavin in the drug.
The drug is not recommended to be taken simultaneously with other multivitamins, as there is a risk of overdose of the remaining ones in the body.
Suspension during pregnancy or breastfeeding.
Clinical studies of the use of Neurobex® have not been carried out on neo-women during the period of gestation, so medication must be administered with caution, especially in the first trimester of gestation, and only for m the doctor at times when the bark in the drug is exposed to a potential risk for the fetus/child.
Vitamin B6 penetrates into breast milk and passes through the placental barrier. High concentrations of vitamin B6 may also suppress milk production. Research shodo
The stage of vitamin secretion in breast milk was not carried out. It is necessary to take the drug carefully before breastfeeding or stagnation of the drug for the mother. If you need to take the drug, start breastfeeding for that period
This is due to the fluidity of the reaction during treatment with vehicles or other mechanisms.
Not revealed.
Compound
The drug contains active ingredients: ascorbic acid - 175 mg, thiamine nitrate - 50 mg, riboflavin - 25 mg, calcium pantothenate - 25 mg, pyridoxine hydrochloride - 10 mg, folic acid - 500 mcg, cyanocobalamin - 5 mcg, nicotinamide - 100 mg .
Additional components: potato starch, magnesium stearate, colloidal anhydrous silicon dioxide, talc and calcium hydrogen phosphate.
The body and cap of the capsule consist of: FD&CA Red 3 dye, D&C Yellow 10 dye, gelatin, titanium dioxide (E171).
Interactions with other medicinal drugs and other types of interactions
With one-hour use of Neurobex® Neo with oral contraceptives or sechoginous drugs, systematic use of alcohol, your metabolism is disrupted and your blood volume changes.
Antihypertensive drugs and drugs that regulate the function of the thyroid gland will convert riboflavin into coenzyme forms. Neuroleptics and peripheral vasodilators inhibit the metabolism of riboflavin. Riboflavin promotes absorption, mobilization and storage.
Vitamin B1, added to the process of polarization in parts of the nerve-muscle synapses, can weaken the curare-like effect of muscle relaxants.
Treatment with antihypertensive drugs leads to a strengthening of arterial hypotension, and with diabetic drugs - to a change in the circulatory effect of the remaining ones.
With one-hour ingestion of nicotinic acid with antithrombotic agents or acetylsalicylic acid, there may be a risk of bleeding. When drinking alcohol for an hour and drinking nicotinic acid, blood vessel deficiency may occur.
When nicotinic acid was taken with astatine, episodes of rhabdomyolysis were reported.
Calcium pantothenate promotes the effectiveness of cardiac glycosides. Reduces the toxicity of streptomycin and other antituberculosis drugs by promoting normal absorption and metabolism of folic acid.
The serum concentration of vitamin B12 may change if taken for one hour with oral contraceptives. The clinical significance of the interaction is not understood.
The absorption of vitamin B12 in the scolitic tract can be changed by one-hour infusion with aminoglycosides, aminosalicylic acid, anti-epileptic agents, biguanides, chloramphenicol, cholestyramine, with potassium supplements, methyldopa and antacids (for example, omeprazole and cimetidine). The clinical significance of the majority of the interactions is probably small.
Vitamin B12 levels in the blood can also be reduced by nitrous oxide, anesthetics, and alcohol.
Pyridoxine may increase the peripheral metabolism of levodopa, reducing the therapeutic effectiveness of the remainder. Therefore, patients with Parkinson's disease who are discontinuing levodopa monotherapy should not take vitamin B6 in doses that exceed their dietary needs. It is important not to worry about these episodes if levodopa stagnates in combination with a peripheral decarboxylase inhibitor.
Pyridoxine may reduce the blood concentrations of anti-drug drugs, such as phenytoin and phenobarbital. Hydralazine and cycloserine are also antagonists of this vitamin. Vitamin supplementation at the same time in the prescribed ways will weaken their side neurological effects.
Vitamin B6 antagonists include isoniazid and thiosemicarbazone. On the other hand, it improves the appearance of the patient with sideroblastic anemia, caused by the so-called anti-tuberculosis methods.
A one-time intake of ascorbic acid (in large doses) with aspirin can cause swelling of the vulva, as well as increased visibility of vitamin C. Their immediate stagnation does not affect the nitric excretion of salicylate and does not reduce the anti-inflammatory effect of aspirin. The immediate use of aluminum antacids and vitamin C may inhibit the excretion of aluminum, so immediate use of aluminum preparations, especially in patients with iron deficiency, is not recommended. through the toxic effect of aluminum in high doses.
Ascorbic acid, when administered orally, promotes the absorption of penicillin, tetracycline, and lysate, and reduces the effectiveness of heparin and indirect anticoagulants.
Ascorbic acid can be removed only 2 years after injection of deferoxamine.
The immediate condensation of ascorbic acid with desferrioxamine promotes excretion of the tissue. Episodes of cardiomyopathy and congestive heart failure have been reported in patients with idiopathic hemochromatosis and thalasemia when treated with desferrioxamine and ascorbic acid. The drug should be administered with caution in such patients and cardiac function should be monitored.
High doses of medication tend to alter the effectiveness of tricyclic antidepressants, neuroleptics similar to phenothiazine, calcium absorption of amphetamine, and interfere with the elimination of mexiletine by nitric acid. Absorption of ascorbic acid decreases with one-hour ingestion of fruit or vegetable juices, or water drinks. Ascorbic acid promotes the clearance of ethyl alcohol.
Ascorbic acid can be combined with biochemical values of creatinine, sechoic acid and glucose in blood and septic samples.
Antiepileptic properties. When folic acid is taken with treatment, folic deficiency, which may be caused by the use of anti-epileptic drugs (phenytoin, phenobarbital and primadone), reduces the number of anti-epileptic drugs in patients Blood levels may decrease, which may consequently lead to a decrease in the effectiveness of treatment in some patients.
Antibacterial agents - chloramphenicol and co-trimoxazole - can interfere with the metabolism of folic acid.
Sulfasalazine - can replace folic acid supplementation.
Methotrexate, perimethamine, sulfonamides and trimethoprim and folic acid antagonists. They inhibit the conversion of folic acid to tetrahydrofolic acid, thereby increasing the risk of developing folic acid deficiency.
Pharmacological authorities
Pharmacodynamics
The combination of group B vitamins, which is included in the Neurobex® Neo drug, influences a number of processes that occur in the body. Vitamins of this group are included in the warehouse of enzymes that catalyze reactions in the metabolism of carbohydrates, lipids and proteins. The combination of group B vitamins in Neurobex® Neo helps to normalize the metabolism of autonomic centers, processes of creation, impulse transmission and trophism of neurocytes, improves the functioning of nerve cells and supporting centers, through which the vegetative-emotional status is normalized.
Vitamin B1 (thiamine nitrate). After resorption, it is transformed in the body into thiamine pyrophosphate, which is a coenzyme of these enzymes, which take part in decarboxylated pyruvic and alpha-ketoglutaric acids.
Thiamine plays a role in carbohydrate and energy metabolism, especially in nerve and meat tissues, and contributes to nerve stimulation at synapses. And also take part in fat, protein and water-salt metabolism, in the synthesis of acetylcholine.
Vitamin B2
Riboflavin plays an important role in supporting the normal function of the eye and hemoglobin synthesis.
When riboflavin enters the body, it interacts with adenosine triphosphoric acid, which metabolizes flavin mononucleotide and flavin adenine nucleotide, which are coenzymes of flavin proteins and take part in the transferred water and regulate it. kisnyuvalno-new processes.
Vitamin B5 (calcium pantothenate).
Take the fate of the produced hormones of the adrenal glands - glucocorticoids; in carbohydrate and fat metabolism, in the synthesis of acetylcholine and corticosteroids. In the body, pantothenic acid is stored before coenzyme A, which plays an important role in the processes of acetylation and oxidation. It improves the processes of regeneration and energy provision of the short-term function of the myocardium, thereby enhancing the cardiotonic effect of cardiac glycosides and promoting their therapeutic effectiveness.
Vitamin B6 (pyridoxine hydrochloride) plays an important role in speech metabolism. It is necessary for the normal functioning of the central and peripheral nervous systems. When it enters the body, it is phosphorylated, converted to peridoxal-5-phosphate and enters the warehouse of enzymes, which contribute to the decarboxylation and transformation of amino acids. Pyridoxin takes part in protein metabolism and the synthesis of neurotransmitters, in the exchange of tryptophan, methionine, cysteine, glutamine and other amino acids. It also plays an important role in the exchange of histamine, in the processes of fat metabolism, improves the function of the liver and nerve fibers, lipid metabolism in atherosclerosis.
Vitamin B9 (folic acid) in the body is converted to tetrahydrofolic acid, which is a coenzyme that takes part in various metabolic processes. Folic acid is necessary for the normal formation of blood cells, including the processes of maturation of megaloblasts and the formation of normoblasts. Lack of folic acid interferes with the transition of the megaloblastic phase of hematopoiesis to the normoblastic phase. Together with vitamin B12, it stimulates erythropoiesis, involving the synthesis of amino acids (for example, methionine, serine), nucleic acids, purines and pyrimidines, in exchange for choline; necessary for subclints.
Vitamin B12 (cyanocobalamin) is converted into cobalamide in the body, which is the active form of vitamin B12. Has high biological activity. A growth factor necessary for normal hematopoiesis and maturation of red blood cells. Take part in the synthesis of labile methyl groups and in the presence of choline, methionine, creatine, and nucleic acids. It reduces the accumulation of sulfides in erythrocytes, which removes sulfhydryl groups, which increases their tolerance to hemolysis. Activates the horticultural function of the blood system, in high doses it causes an increase in thromboplastic activity and prothrombin activity. Activates the exchange of carbohydrates and lipids. In case of atherosclerosis, it further reduces the level of cholesterol in the blood and increases the lecithin cholesterol index. It has a beneficial effect on the function of the liver and nervous system. Increased tissue regeneration.
Vitamin PP (nicotinamide) contains a prosthetic group of enzymes - codehydrase (diphosphopyridine nucleotide - NAD) and codehydrase (triphosphopyridine nucleotide - NADP), which transport water and ensure oxidative processes. Codehydrase shares the same fate as the transferred phosphate. Vitamin PP has a specific antipylagric effect. By reducing carbohydrate metabolism, it is positive for mild forms of diabetes, liver disease, heart disease, disease of the intestinal tract, and severely congested wounds and wounds. It also causes vasodilator activity, hypolipidemic activity: it reduces the level of cholesterol, low-density lipoproteins and especially triglycerides; Instead, high-density lipoproteins grow in the blood.
Vitamin C (ascorbic acid). Take part in the regulation of oxide-related processes, carbohydrate metabolism, throated blood, tissue regeneration, established steroid hormones, and may well express the power of the world. One of the important physiological functions of ascorbic acid is the synthesis of procolagen and collagen, as well as the normalization of capillary permeation. And data about the positive effect of ascorbic acid on lipid metabolism in atherosclerosis.
Pharmacokinetics
The components of the complex (group B vitamins) are absorbed from the small intestine, bound to plasma proteins, and distributed in the tissues. The body undergoes biotransformation and is important to be excreted (both in the unchanged state and in the form of metabolites). After oral administration, cyanocobalamin is absorbed passively into the small intestine and small intestine without the presence of an intrinsic factor. The liquid content of vitamin B12 is stored in the dose.
After oral administration, ascorbic acid is easily absorbed from the scolio-intestinal tract. From the blood plasma it penetrates into the blood elements (leukocytes, platelets, erythrocytes), then into all tissues. Ascorbic acid is reversely oxidized with dihydroascorbic acid, partly metabolized with ascorbate-2-sulfate and oxalic acid, which is excreted from the stomach. Excess ascorbic acid is quickly eliminated from the body without change.
