Instructions for the use of Nystatin suppositories and their effectiveness in the treatment of thrush

Nystatin is a polyene antibiotic that is active against pathogenic fungi.

It is used for the treatment and prevention of diseases caused by microorganisms against which the drug is effective. It is produced in the form of tablets for oral use, as well as in the form of suppositories for vaginal and rectal administration. Usually well tolerated by the body, except in cases of intolerance to the drug.

Therefore, to cure thrush you need not only competent treatment, but also effective medications. To treat such diseases, antifungal antibiotic drugs are needed. One such drug is Nystatin.

Drug composition and release forms

The drug is available in the following forms:

• In the form of vaginal and rectal suppositories , which can comprehensively affect the infection. The candles are packed in special cells in the amount of five pieces. One package contains detailed instructions on how to take the medicine. Such candles are produced in the shape of a torpedo, with a yellowish tint.
• In tablet form. The dragees are covered with a light yellow shell. The tablets have a slight vanilla scent. Such tablets are available for sale in quantities of twenty pieces in dark glass bottles. Tablets are also available for sale in special contour cells in a cardboard packaging box.
• In the form of an ointment . The ointment is intended for external use. The color of the composition of the drug is brownish-yellow. Available in specially designed tubes.

Ointment

Nystatin

Candles
Composition:

• One tablet contains nystatin, as well as auxiliary, additional components in the form of milk sugar, magnesium carbonate, potato starch, vanillin and other components.
• One suppository for rectal administration contains nystatin and auxiliary components in the form of propyl ether and parahydroxybenzoic acid. Also included in the additional components is citric acid, as well as petroleum jelly.
• One suppository for vaginal administration contains nystatin and auxiliary components in the form of propyl ester of parahydroxybenzoic acid, as well as citric acid.
• Composed of one gr. The external ointment contains nystatin and an auxiliary component in the form of anhydrous lanolin and medical petroleum jelly.

Medical certificate

Nystatin is an antifungal drug that comes in several forms:

1. Vaginal/rectal suppositories. They have a comprehensive effect on the infectious process.
2. Pills. Covered with a yellowish shell, they have a pronounced vanilla smell. Can be packaged in dark glass bottles or blister packs and cardboard packs.
3. Ointment. The product has a brownish-yellow tint. Packaged in aluminum tubes. Intended for outdoor use only.

The drug is mainly used in gynecology, less often in proctology. According to reviews, Nystatin suppositories have a pronounced and rapid therapeutic effect. It is this form of medication that we will dwell on in more detail in today’s article.

Pharmacological properties

Nystatin is an antifungal drug intended for topical use. This drug belongs to the group of polyenes. When nystatin enters the mucous membrane, a process is initiated that allows the active substance of the drug nystatin to be slowly released.

The drug begins to penetrate the membranes of the cells of the pathogens sitting inside, which caused the infection. Subsequently, the drug disrupts permeability. This process leads to the cessation of further development and reproduction of the infection, and subsequently to its complete destruction.

The drug is quite highly effective in comparison with other drugs and is very stable against yeast-like fungi.

Will nastatin suppositories give results for thrush?

To correctly and effectively prescribe an antifungal drug, the doctor must take into account the sensitivity of the pathogen to the active substance. To do this, bacteriological seeding of the pathological discharge is performed using a special medium.

The appearance of a certain number of colonies of yeast fungi from the genus Candida indicates a candidiasis infection. Afterwards, the sensitivity of the inoculated microorganism to various antifungal drugs is determined.

Thus, if, according to the results of the analysis, pathogenic fungi in a woman are sensitive to nystatin, its prescription will be correct and justified, and the effect will not be long in coming.

Types of Nystatin suppositories

The manufacturer of the drug nystatin produces quite a variety of forms of the drug that are suitable for any patient. Most often, in gynecology, suppositories are used, of course.

1. Firstly, it should immediately be noted that suppositories really fight diseases and it is suppositories that are able to penetrate the walls of the mucous membrane and have an effect on infection. In addition, the drug not only has an effect on infections, but also destroys their structure, and also stops the development in the body of any woman. This cannot be ignored, of course.
2. Secondly, candles are different. Candles are produced for different purposes. Often, gynecologists prescribe treatment with suppositories for rectal administration. That is, such treatment involves administering a suppository through the rectum. In addition, patients are prescribed suppositories in one course of treatment by vaginal administration.

Thus, the medicine has a complex effect on the body and penetrates in full through the walls of the mucous membrane. Thus, the active substance begins to destroy the infection and stops its further development.

The difference between vaginal suppositories and rectal suppositories

As noted earlier, Nystatin is available in the form of suppositories for both rectal and vaginal use. What is the difference?

Vaginal suppositories	Rectal suppositories
Suppositories for vaginal use do not contain petroleum jelly. The composition of the suppositories is identical and differs only in the way in which the drug must be administered. In appearance, the candles are no different from each other. They are quite familiar in shape and no different from other candles.	In the composition of suppositories for rectal use, Vaseline oil is added as an auxiliary, additional component. This additive is required for more comfortable insertion of suppositories.

Very often, doctors prescribe treatment with both rectal and vaginal suppositories. A special feature is that suppositories must be purchased in two types and in no case should suppositories for vaginal administration be inserted into the rectum.

If the doctor has prescribed insertion of suppositories in the morning - rectally, and in the evening - intravaginally, then in no case can you get by with one package of suppositories intended for rectal administration. Candles should not be mixed or mixed.

What are Nystatin suppositories?

Nystatin suppositories for thrush are a torpedo-shaped remedy with a yellow color. The suppositories themselves are enclosed in blister packs of 5 pieces.

The main active ingredient is nystatin, a polyene antifungal drug discovered in 1950. It is capable of not only suppressing growth, but also destroying fungal cells. The mechanism of action is to block specific enzymes that trigger sterol formation reactions. These substances belong to the basic components of the cell wall of the pathogen.

Auxiliary ingredients:

1. Witepsol 35.
2. Lemon acid.
3. Vaseline oil.
4. Witepsol 15.
5. Propyl ester of parahydroxybenzoic acid.

Thus, impaired biosynthesis of ergosterols contributes to increased cell membrane permeability. As a result, a huge amount of sodium, potassium, chlorine and water ions enter the cell. As a result, the fungus cannot withstand and destroys itself.

Indications for use

Suppositories are prescribed to patients directly for both vaginal and rectal administration.

The indications are based on factors such as:

• candidiasis caused by Candida fungi, in other words it is thrush.
• In addition, Nystatin is indicated for use for the purpose of preventive work to prevent the development of the disease. This can be caused when the patient is treated for a long time with antibiotics or with topical antibacterial agents. After all, as you know, it is long-term use of antibiotics that can lead to the development of thrush.
• Nystatin is also indicated for use in cases of damage to the mucous membrane in the area of ​​the large intestine, namely the lower section.
• can help after surgical interventions ; in the area of ​​the lower intestines, treatment with such a drug is also indicated in order to carry out prophylaxis for further getting rid of fungal infection.

Use of the drug among pregnant and lactating women

As you know, pregnant women and women during breastfeeding need increased attention from doctors. In addition, the doctor should regularly examine such women and monitor their health status. It is known that during pregnancy women have many contraindications.

The use of a medicine such as Nystatin is not recommended in any trimester of pregnancy.

Despite the fact that studies were carried out and no effect on the gestating fetus was noted. Suppositories are recommended to be taken only in situations where there are acute indications for this.

Before starting the therapy process, the doctor must evaluate the level of risk and benefit of this medication for women. During breastfeeding, the use of suppositories such as Nystatin is allowed only in consultation with a doctor.

There is no information that the composition of the medicine is released along with milk. If therapy cannot be postponed until another time, then it is better to stop breastfeeding for a while.

Use in childhood

It's no secret that candidiasis also appears in girls at an early age. Treatment at this age is especially important to choose correctly and competently. As noted earlier, Nystatin is produced not only in the form of suppositories, but also in tablet form and ointment form.

If for some reason the use of a suppository is contraindicated, then you can choose any other form of release of the drug Nystatin. The use of suppositories is allowed for children as prescribed by a doctor.

It is prohibited to prescribe treatment for a child on your own. The doctor must examine the young patient. Only a doctor can prescribe treatment for a young girl with suppositories such as Nystatin.

In what cases do Nistanin suppositories help?

Nystatin suppositories are prescribed to patients for vaginal and rectal use. The main indications for the use of this drug are:

1. Vaginal candidiasis caused by yeast-like fungi of the genus Candida (thrush).
2. Damage to the mucous membranes of the lower parts of the large intestine.
3. Prevention of fungal infections of the intestine after operations on the lower parts of the large intestine.
4. In order to prevent the development of fungal diseases during long-term treatment with antibiotics or local antibacterial agents.

Method of administration and dosage of the drug

A drug such as Nystatin is used in two ways: intravaginally and rectally.
The method of administration depends, first of all, on the indications and prescription of the doctor. To take this drug, the patient must lie in a comfortable position and insert the suppository deep into the cavity of the rectum or vagina.

The drug must be administered one piece at a time twice a day. After the drug has been administered, the patient must remain in the same position so that the medicine dissolves and does not leak out.

The course of therapy can continue for as long as it is prescribed directly with the doctor.

According to the instructions, treatment lasts on average about two weeks. If there is no therapeutic effect or the condition worsens, the patient should consult a doctor. It is also worth keeping in mind that during therapy with this drug, discharge may be increased. As prescribed by the doctor, the course of therapy can be prescribed again.

Dosage regimen

For correct and convenient insertion of vaginal suppositories, a woman should take a supine position. Your legs should be slightly spread and your knees bent. It is recommended to perform toileting of the external genitalia first.

Then a suppository should be inserted deep into the vagina. Movements should be slow and careful. In gynecology, instructions for the use of Nystatin suppositories indicate that the course of therapy usually lasts 10-14 days. In this case, the suppository should be administered twice a day (usually in the morning and evening).

Rectal suppositories are administered a little differently. You should first defecate and perform hygiene procedures. It is necessary to take a horizontal position on your side. The legs should be bent at the knees and brought to the chest. Using your fingers, you need to carefully spread the buttocks and slowly push the candle along the rectum. The dosage regimen is 2 suppositories per day. It is advisable that about 12 hours pass between doses. The duration of treatment is 10-14 days.

In case of vaginal candidiasis, together with the woman, her immediate partner should also undergo therapy. Especially when it comes to infection with fungal and bacterial flora. Otherwise, the risk of relapse due to re-infection is quite high. For men, nystatin ointment is usually recommended for treatment. Throughout the course of therapy, sexual contact should be limited, and if impossible, use barrier contraception.

Contraindications

Of course, before you start using a particular drug, you need to familiarize yourself with the list of contraindications.

In fact, Nystatin is a harmless drug that has no restrictions as such . When using Nystatin suppositories, the patient must consult a doctor and obtain permission.

The drug is contraindicated in the following cases:

• for diseases of a vital organ - the liver, which is accompanied by a malfunction of the organ itself;
• the period of bearing a baby and the period of breastfeeding;
• lack of perception of any components included in the basis of the drug;
• discharge with blood particles from the genital tract, the nature of which has not been examined and is unknown.
• inflammatory processes of hemorrhoidal nodules;
• presence of bloody discharge from the anus;
• the presence of malignant neoplasms in the rectum.

Doctors' recommendations

Doctors give the following instructions when using Nystatin suppositories:

1. During menstruation, if the treatment process has already begun, it is not worth interrupting it. However, when a woman knows the date of her menstruation, it is better to postpone therapy.
2. If discomfort or pain occurs during the administration of suppositories, you should contact a specialist for a second consultation.
3. Before prescribing treatment, a woman must undergo a comprehensive examination. Through diagnostics today it is quite easy to detect infectious processes. If they have been identified, both sexual partners should consult a doctor.

Following these simple recommendations will speed up the healing process.

Side effects

Side effects can occur in any patient after taking a particular drug. It should be noted that the side effects can be absolutely anything. After all, some people cannot tolerate the drug at all, while others may experience complications after the treatment period.

Like any other drug, Nystatin also has a number of side effects that may occur after using the drug, as well as during treatment. In general, this drug is quite well tolerated by patients when the dose is observed in accordance with all the rules.

Those patients who experience increased individual sensitivity may develop side effects such as:

• burning sensation and itching in the vaginal area;
• swelling of the mucous membrane;
• urge to defecate;
• sensation that there is a foreign body in the colon.

In adults with liver disease, the first disease that develops is liver failure.

To avoid side effects from appearing in the patient, it is necessary not only to comply with the dosage, but also to take the drug correctly. To do this, you must follow the treatment regimen prescribed by your doctor.

Features of the use of nystatin suppositories

Nystatin is well tolerated, does not penetrate into the general bloodstream, and does not cause side effects when used locally.

Pregnancy

Suppositories are not prescribed in the first trimester. In the second and third cases, therapy should be carried out under the supervision of specialists. Self-medication is not allowed. A direct contraindication is the presence of individual intolerance. If, after inserting the suppository, you feel a burning sensation, itching, discomfort in the vagina, swelling, or rashes, you must stop treatment and seek help from specialists. Candles are used once a day before bedtime for no more than 10 days.

Menstruation

The suppositories quickly dissolve, the active components are absorbed by the mucous membranes. It is allowed to use the drug during menstruation. Blood does not reduce the effectiveness of nystatin. It is convenient to treat thrush if its manifestation is associated with hormonal changes on the eve of menstruation.

It should also be borne in mind that Nystatin, with any use, reduces the effectiveness of Clotrimazole.

Overdose

It is worth noting that the dosage for each patient can be set individually. A drug such as Nystatin in the form of suppositories begins its action and effect when absorbed into the human blood system.

Even though the suppositories will be used for a long time, an overdose is almost impossible.

If you accidentally ingest suppositories, you must urgently induce a gag reflex and drink activated charcoal.

Advantages and disadvantages of using suppositories for thrush

Advantages of using topical medications for candidiasis in women:

• When the drug is administered to a place where fungi actively multiply, the effect of local treatment appears much faster, especially when using modern effective drugs such as Livarol or Zalain.
• Modern antifungal agents can be used once.
• Because systemic absorption of topical medications is low, the incidence of side effects is reduced, unlike oral therapy.

Disadvantages of local treatment:

• Local treatment causes some inconvenience to a woman - it stains her underwear and limits her sex life.
• A positive effect from such therapy is possible only in mild forms of thrush, but when the course of the disease is more severe and prolonged, local therapy should be supplemented with the use of antifungal drugs in tablets. Therefore, it is often necessary to repeat the course of treatment after a certain time.
• When using combined antimicrobial drugs, such as Terzhinan, Polygynax, a common side effect is vaginal dysbiosis, which then requires additional treatment, for example, the use of suppositories with lactobacilli - Lactonorma, Acylact, Lactobacterin, Ecofemin or Vagiflora.

Interaction of the drug with other drugs

Quite often, when prescribing treatment, doctors prescribe several drugs that can overcome the disease.
It is worth making a reservation, drugs that help eradicate the problem of candidiasis contain active substances. It is precisely due to such circumstances that not all groups of drugs are compatible. Especially when it comes to drugs for the treatment of sexually transmitted infections.

In gynecological practice, a drug such as Nystatin is not recommended for use in parallel with the drug Clotrimazole. It is worth noting an important factor - the presence of a sufficiently highly active substance that can displace the active substances of other drugs. When two drugs interact, the effectiveness of Clotrimazole is significantly reduced.

In addition, it is not recommended to douche while taking a drug such as Nystatin. This is explained by the fact that the therapeutic effect of the suppository is significantly reduced.

Treatment with antibiotics

Nystatin-based suppositories are often used to prevent fungal diseases of the vagina during antibiotic treatment. This is explained by the fact that during such treatment, not only pathogenic microflora perishes in the human body, but also useful, natural ones. This process promotes the growth of pathogenic microflora and, accordingly, various types of fungi. Thus, candidiasis develops as a side effect of antibiotic treatment.

To avoid the addition of new diseases, doctors prescribe the use of antifungal agents for women, including Nystatin suppositories. However, it must be remembered that this drug is contraindicated for use during pregnancy. If a woman is in the early stages of bearing a baby, she must inform the doctor who has prescribed antibiotic therapy and antifungal suppositories. The same applies to nursing women who have an individual intolerance to the drug, which is confirmed by the instructions for use and reviews included with the Istatin suppositories.

special instructions

The drug Nystatin is one of the drugs that has been proven over the years, inexpensive, affordable for anyone, and its composition and pharmacological properties are in no way inferior to modern drugs.

Special instructions for use:

1. It happens that during the treatment you feel discomfort, burning and itching. In such situations, the help and consultation of a doctor is certainly necessary.
2. Often women are faced with such problems as the need for treatment and menstruation . Often, gynecologists prescribe treatment with this drug in the form of suppositories. If the patient knows in advance that menstruation will occur in the near future, then it is best to postpone therapy with Nystatin.
3. If it turns out that the critical days have already arrived, and the treatment process has already begun , then there is no need to stop therapy. Treatment should be continued as before, according to the established schedule.
4. With diagnosis and laboratory testing, it is usually quite easy to detect any infection. If such an infection is detected, then both sexual partners should be consulted.
5. When diagnosing sexually transmitted infections, it is recommended that partners also undergo treatment and therapy together. During therapy, it is recommended to abstain from sexual intercourse, as well as choose a method of contraception for the near future.

Reviews from women

Numerous positive reviews about their use as a treatment for thrush and other fungal diseases will help you verify the effectiveness of nystatin suppositories.

1. Nastya. I took nystatin for thrush. I have encountered this problem several times and tried many remedies. I used candles. I liked the fact that they are very easy to use and do not cause any discomfort. When first used, there was a slight burning sensation, which disappeared later. The symptoms began to decrease after 4 days, and complete treatment took me 10 days. I was very pleased, as the drug is inexpensive, but at the same time effective.
2. Karina. I was advised to buy Nystatin suppositories at the pharmacy. They cost about 55 rubles, which is 10 times cheaper than many other drugs, and the effect was no worse. The big plus is that the effect is almost immediate and there are no side effects.
3. Anna. Of all similar drugs, Nystatin is the cheapest. Despite the low cost, I think the drug is effective. I took it in the form of granules for solution, there were no side effects. It took me 2 weeks to completely eliminate mycosis of the skin. For prevention purposes, I applied the ointment to the affected areas for another week.

Reviews of Nystatin suppositories for thrush are associated with side effects: increased urination, irritation, burning sensation in the vagina. Women often stopped treatment immediately after the symptoms disappeared, while the pathogen was not eliminated and the symptoms returned after a while. According to many women, these suppositories are not very effective; they believe that the drug is “outdated” and prefer modern antimycotic drugs. There are also reviews that these suppositories were prescribed during pregnancy to treat thrush.

Analogues of Nystatin suppositories

Despite the fact that the drug is sold in pharmacies at a fairly affordable price, there are analogues to this drug and most people give their choice to analogues. This is explained by the fact that Nystatin in any form is not suitable for every patient. Not everyone is able to tolerate the active substance of the drug.

Like many other medications, Nystatin has its own analogues that can replace this drug.

According to therapeutic effect, drugs can also be selected as:

• Pimafucin;
• Nitrofungin;
• Moronal.

Nitrofungin

Pimafucin (natamycin)

Moronal
These drugs have increased activity in the treatment of candidiasis. It is not recommended to change medications on your own; you should consult a doctor.

When is it important to use suppositories against thrush in women?

Local use of intravaginal suppositories allows you to achieve the removal of Candida from the mucous membranes and relieve a woman from the manifestations of thrush in the shortest possible time.

Suppositories have local activity and create the most effective concentration of the active substance in the vagina. Nystatin is almost not absorbed into the bloodstream. And this property eliminates the occurrence of severe adverse reactions.

Vaginal suppositories are classified as combined medications with antifungal and antimicrobial effects.

If a patient is diagnosed with long-term or recurrent thrush, it is best for her to use intravaginal suppositories.

Sometimes it is difficult to use tablets with thrush - due to injuries or pathologies of the digestive organs. In this case, candles are the most preferable option.

These suppositories are indicated for use in the prevention and treatment of pathologies caused by yeast-like fungi Candida, especially in the vulvovaginal area. For prophylactic purposes, it is prescribed to prevent the appearance of thrush during treatment with penicillin and honey with drugs of other groups.

Drug price

The price of Nystatin in various forms of release depends on various factors: the city, the manufacturer of this medicine. That is why, before purchasing this drug, it is worth checking how different prices are in pharmacies.

On average in Russia the cost of various dosage forms of Nystatin is as follows:

• tablets of 250 thousand units, 20 pieces per package - 14-16 rubles;
• tablets 500 thousand units, 20 pieces per package - 13-30 rubles;
• Fungostatin granules, 100 thousand units, 7.5 g per package – 400 rubles;
• vaginal suppositories 250 thousand units, 10 pieces per package – 33-40 rubles;
• vaginal suppositories 500 thousand units, 10 pieces per package – 42-60 rubles;
• rectal suppositories 500 thousand units, 10 pieces per package – 47-80 rubles;
• ointment 100 thousand units per 1 g, tube 15 g – 21-48 rubles;
• ointment 100 thousand units per 1 g, tube 30 g - 30-45 rubles.

Before use, you should consult a specialist.

Terms of sale and storage of medicines

Due to the fact that sales of drugs in pharmacies are currently being tightened, it is worth asking in advance how such a drug as Nystatin is sold in pharmacies.

Nystatin suppositories can be purchased in pharmacies only with a doctor's prescription. Therefore, to purchase the drug, it is better to consult a doctor and get the appropriate prescription.

It is recommended to store candles in a dry place, preferably away from light. It is necessary to maintain a temperature regime of no more than 10 degrees. The shelf life of such a medicine is two years from the date on which it was manufactured.

Side effects

Nystatin, as a rule, does not cause side effects, but in case of increased sensitivity, the following side reactions are possible:

on the side of the grass system:

Possible nausea, vomiting, diarrhea;

on the side of the immune system:

increased body temperature, chills; allergic reactions, including skin irritation, itching, and kropivyanka; reactions at the site of congestion, which may manifest themselves as liver pain, pain, itching, tingling or irritations;

more:

It is possible that resistant forms of fungi may become widespread, which will require changing the drug and changing the treatment tactics.