13 Lupus Symptoms That Are Dangerous to Ignore

Systemic lupus erythematosus is a disease that causes an immune response against the body's own cells. The causes of the pathology are not fully understood. Provoking factors contributing to the development of the disease are identified. The symptomatic picture of SLE depends on which organ it affects. A comprehensive diagnosis of the disease makes it possible to determine the location and degree of activity of the pathology. Despite the fact that systemic lupus erythematosus is currently considered an incurable disease, long-term use of medications can minimize the number of exacerbations of autoimmune pathology. In the international classification of diseases ICD-10, systemic lupus erythematosus is coded M32.

Systemic lupus erythematosus - what is it?

Systemic lupus erythematosus is a chronic autoimmune disease in which the body's own cells are recognized as foreign. In this regard, an immune response develops, causing inflammatory processes in the organs. Currently, experts have not come to a consensus regarding the causes of the disease. There are a number of predisposing factors that increase the risk of developing SLE. Most often, autoimmune pathology affects females under the age of 30. Systemic lupus erythematosus is characterized by a severe course. It affects various organs and tissues. The most specific symptom of the presence of pathology is “lupus butterfly”. Due to the fact that the clinical signs of the disease are similar to other diseases, the diagnosis and treatment of SLE is delayed. Modern diagnostic tests can accurately detect the presence of systemic lupus erythematosus. Therapy for the disease is aimed at suppressing the mechanisms of its development, as well as alleviating clinical symptoms.

At the moment, systemic lupus erythematosus is an incurable disease. Thanks to constant use of medications, long-term remission is achieved. There are a number of preventive measures, the observance of which reduces the risk of exacerbation of systemic lupus erythematosus.

The Yusupov Hospital provides a full course of treatment and diagnostic measures necessary to identify this chronic autoimmune disease. The appearance of the first signs of pathology requires immediate medical attention.

Expert opinion

Author:

Anna Olegovna Pchelintseva

Rheumatologist, doctor of the highest category

Compared to the mid-20th century, modern medicine has made significant progress in the treatment of systemic lupus erythematosus. The survival rate has increased to 90–95%. It depends on the stage at which the diagnosis was made and what therapy the patient receives. In the structure of mortality, systemic lupus erythematosus does not occupy a leading position. The number of deaths varies depending on different conditions. It has been proven that women are several times more likely to suffer from SLE compared to men.

The disease is still considered incurable. However, properly selected therapy can achieve long-term remission. At the Yusupov Hospital, systemic lupus erythematosus is diagnosed using radiography, angiography, echocardiography, and ECG. A modern laboratory performs a blood test to identify markers of inflammation. In accordance with the data obtained, rheumatologists select suitable treatment. For each patient, a therapeutic plan is developed individually. The drugs are selected according to the latest European recommendations for the treatment of systemic lupus erythematosus.

Folk remedies

Photo: oldhome.spb.ru

Systemic lupus erythematosus is a chronic disease. This means that the disease will accompany a person throughout his life, so a complete cure cannot be achieved. It is clear that traditional medicine will not get rid of this disease, but will help improve overall well-being.

For example, to treat skin manifestations of SLE, sea buckthorn oil is used, which you can prepare yourself or buy at a pharmacy. You should lubricate problem areas with oil twice a day (morning and evening), having previously prepared the skin (cleanse it of impurities). You can also prepare an ointment based on unsalted pork fat and celandine juice. Pork fat is melted in a water bath with the addition of celandine juice in a ratio of 10:1. After which it is thoroughly mixed and cooled. Upon reaching a comfortable temperature for use, apply to problem areas.

To treat affected joints, in particular, to eliminate pain, chestnut tincture is used. It is recommended to apply the tincture to the disturbing joints, then wrap them in a woolen scarf or scarf. The duration of such treatment is 7–10 days.

When kidney damage occurs due to SLE, herbal decoctions have a good effect. Herbs such as black currant, bearberry, lingonberry leaves, rose hips, birch leaves, and juniper fruits have a beneficial effect on kidney function.

It is important to remember that when treating SLE you should not take drugs that enhance the functioning of the immune system, as this will increase the aggressiveness of the process. Therefore, it is not recommended to use traditional medicine recipes on your own; you need to seek help from a doctor who will be able to competently handle the process of choosing decoctions and infusions.

The information is for reference only and is not a guide to action. Do not self-medicate. At the first symptoms of the disease, consult a doctor.

Causes and mechanism of development of lupus erythematosus

Until now, it has not been possible to establish the exact causes of the development of systemic lupus erythematosus. In this regard, there is no etiotropic treatment of the disease. Experts identify some predisposing factors, the presence of which significantly increases the risk of systemic lupus erythematosus. These include:

• Hereditary predisposition. This factor is not the main one, however, the presence of SLE in relatives increases the possibility of developing an autoimmune disease.
• Prolonged exposure to direct sunlight. Systemic lupus erythematosus is accompanied by the development of photosensitivity. Ultraviolet radiation provokes an exacerbation of the disease.
• Occupational hazards. Frequent contact with chemicals has a negative impact on health. This situation can lead to the onset or exacerbation of systemic lupus erythematosus.
• Smoking. It has been proven that tobacco impairs blood microcirculation. Smoking significantly worsens the course of systemic lupus erythematosus, leading to long-term relapses.
• Taking certain medications. Hormonal drugs in high doses provoke an exacerbation of the disease.
• Stressful situations and excessive physical activity. These factors can worsen the course of SLE or provoke its exacerbation.
• Female. According to statistics, women are more susceptible to systemic lupus erythematosus than men.

An autoimmune disease is characterized by the fact that the body perceives its own cells as foreign. The mechanism of development of systemic lupus erythematosus is associated with the formation of antibodies to one’s own cells. This leads to the formation of circulating complexes that settle on the surfaces of organs. This process leads to the development of an inflammatory process.

Disease during pregnancy

Symptoms of lupus disease can occur during pregnancy in any trimester. Very often, many women confuse the first signs of the disease with changes in the body during pregnancy.

If lupus develops during pregnancy, a woman may experience the following types of complications:

• Increased blood pressure;
• Kidney disease;
• Miscarriage occurs in 25% of women who suffer from the disease during pregnancy;
• The consequence is premature labor;
• Blocking the development of the fetus during pregnancy, as a result of which the child may be born with developmental disabilities;
• The formation of blood clots in the placenta, which reduces the normal supply of nutrients to the fetus.

If a woman is diagnosed with a disease during pregnancy, the entire period of prenatal work is carried out under the close supervision of doctors in a hospital setting.

Systemic lupus erythematosus: symptoms

The disease is accompanied by damage to various systems. Systemic lupus erythematosus is characterized by a chronic course with periods of remission and relapse. The clinical picture of the disease includes the following general symptoms:

• Weakness, increased fatigue.
• Loss of body weight.
• Hyperthermia.
• Decreased performance.
• Headache, heaviness in the head.

Symptoms of systemic lupus erythematosus may develop gradually or occur acutely and suddenly. This factor is determined by the location of the lesion. In accordance with this, the lesion is distinguished:

1. Musculoskeletal and muscular system.
2. Skin.
3. Respiratory system.
4. Organs of the cardiovascular system.
5. Urinary system.
6. Nervous system.
7. Gastrointestinal tract.
8. Blood.

Damage to the musculoskeletal and muscular system

Connective tissue, which is most affected by systemic lupus erythematosus, is found in large quantities in joints and bones. This determines the prevalence of articular manifestations of the disease. The main signs of SLE with damage to the musculoskeletal system include:

• Pain. Appears in 90% of cases with systemic lupus erythematosus. The pain syndrome most often affects small joints on the hands. The clinical sign may spread to symmetrical joints. However, this rarely happens.
• Joint deformity. Changes in the configuration of the joint are permanent.
• Myositis. Pain in the muscles causes stiffness of movement, severe weakness and decreased performance.

Skin damage

Clinical signs of skin lesions in systemic lupus erythematosus appear in 60-75% of cases. The disease is characterized by the following symptoms:

• "Lupus butterfly." One of the most striking signs of systemic lupus erythematosus. The rashes are localized in the cheeks, nose, bridge of the nose, rarely on the torso and arms. The appearance of redness can be provoked by prolonged exposure to the sun or a stressful situation.
• Alopecia. Hair loss with systemic lupus erythematosus is rare. Skin appendages (hair, nails) become brittle and dry.
• Photosensitivity. The symptom is diagnosed in more than half of the cases. This results in increased sensitivity to sunlight.

Respiratory system damage

Symptoms of the presence of systemic lupus erythematosus in the respiratory system are detected in more than half of the cases. The most common diagnoses are lupus pneumonitis or pleurisy. Clinically, this is expressed in the appearance of shortness of breath, cough with sputum, which may contain bloody discharge. An autoimmune disease makes the body accessible to infectious agents. In this regard, infectious lung lesions may develop.

Damage to the cardiovascular system

Systemic lupus erythematosus causes damage to all structures of the heart. When diagnosing inflammation, the infectious agent is not detected. At the beginning, the disease is accompanied by the appearance of myocarditis, pericarditis, or endocarditis. As the pathology progresses, the process spreads to the valves. The mitral and tricuspid are most often affected. The presence of systemic lupus erythematosus increases the risk of developing atherosclerotic disease. Vascular damage is also possible, which provokes the development of heart attacks.

Damage to the urinary system

SLE most often affects the renal system. Lupus nephritis occurs, characterized by an inflammatory process in the kidneys. In this case, fibrin deposited in the glomerular membrane forms hyaline blood clots. Systemic lupus erythematosus leads to decreased renal function. Proteinuria and erythrocyturia appear in the urine. There may be cases when laboratory changes in urine are the only clinical manifestation of damage to the renal apparatus.

Damage to the nervous system

Damage to the blood vessels of the brain caused by systemic lupus erythematosus causes disorders of the central nervous system. Clinical symptoms of the disease are:

• Irritability, anxiety.
• Obsessive ideas, psychoses, hallucinatory phenomena.
• Migraine-type headache.
• Myelopathy, polyneuropathy.

Damage to the gastrointestinal tract

The frequency of diagnosing clinical symptoms of damage to the gastrointestinal tract in SLE is about 25%. The main signs of pathology include:

• Swallowing disorder. The symptom occurs due to damage to the esophagus.
• Peptic ulcer of the stomach or duodenum. An exacerbation may be caused by the presence of SLE or the effect of its treatment.
• Feeling of nausea, possibly vomiting.
• Abdominal pain of various types. Systemic lupus erythematosus acts as a cause of exacerbation of chronic diseases. For example, chronic pancreatitis.

Blood damage

For systemic lupus erythematosus, a specific sign of blood damage is the appearance of LE cells. The disease is accompanied by the recognition of the body's own cells as foreign. As a result, white blood cells destroy and absorb similar blood cells. SLE causes anemia, thrombocytopenia, and leukopenia. These signs may be clinical manifestations of an exacerbation of the disease or occur as a result of drug treatment.

Systemic lupus erythematosus is a disease characterized by a variety of clinical manifestations. Late seeking medical help occurs due to the disguise of signs of pathology as other diseases.

Diagnosis of systemic lupus erythematosus

Systemic lupus erythematosus requires a complex of diagnostic studies. The American College of Rheumatology has developed criteria, the presence of which helps in making a diagnosis. Identification of 4 of 11 criteria is the basis for diagnosing SLE. These include:

1. Joint pain. The symptom is accompanied by swelling in the area of ​​the affected joint, limited mobility, and stiffness of movement. A small amount of fluid may accumulate in the joint cavity.
2. Skin rashes. Systemic lupus erythematosus is characterized by red rashes of various shapes. Scales form on the surface of the affected area, which do not separate on their own. The most common localization of rashes is the face, skin of the hands, and neck.
3. Increased sensitivity to light. Prolonged exposure to direct sunlight is a risk factor for the development of systemic lupus erythematosus.
4. Damage to mucous membranes. The disease manifests itself in the form of ulcerations in the nasopharynx. Most often, such rashes are painless.
5. Rash on the nose and cheeks. Lupus butterfly is a specific symptom of systemic lupus erythematosus.
6. Damage to the urinary system. Due to the spread of the autoimmune process to the kidney area, daily protein loss occurs in the urine.
7. Lung damage. SLE often affects the body's respiratory system. This manifests itself in inflammation of the serous membranes. As a result of the pathological process, pleurisy is formed.
8. Damage to the central nervous system. Clinical manifestations of this localization of systemic lupus erythematosus are not specific. Psychosis, seizures, and hallucinations may occur.
9. An increase in antibodies in the blood. One of the criteria for the presence of SLE is an increase in the concentration of antinuclear antibodies (ANA).
10. Blood damage. The autoimmune disease is accompanied by anemia, thrombocytopenia, and leukopenia. In addition, the diagnosis of systemic lupus erythematosus allows one to determine the presence of LE cells in the blood.
11. Changes in the immune system. SLE is an autoimmune disease in which the body's own cells are perceived as foreign.

To confirm the presence of systemic lupus erythematosus, laboratory and instrumental studies are performed. Among them are:

• Blood analysis. This study is necessary to determine markers of the inflammatory process. These include C-reactive protein, ESR, and leukocytes.
• Analysis of urine. With systemic lupus erythematosus, an increased content of protein, red blood cells, casts and leukocytes in the urine is determined.
• Blood chemistry. It is carried out to determine the degree of organ damage. An increase in creatinine concentration indicates the presence of kidney damage; transaminases increase if the process spreads to the liver area.
• ECG, EchoCG. These studies are necessary to determine the extent of heart damage. SLE may present as endocarditis, myocarditis, or pericarditis.
• X-ray of the chest organs. An instrumental examination is carried out to identify lung damage. Pleurisy and pulmonary embolism are diagnosed in a similar way.
• Angiography. Suspicion of a stroke or vascular damage requires a contrast study.

There are specially designed diagnostic tests to detect systemic lupus erythematosus. Among them are:

There are several forms of lupus erythematosus, which must be differentiated from each other. These include:

• Drug-induced lupus erythematosus. It is a reversible disease. The main reason for the development of pathology is the use of certain medications. Clinical symptoms do not differ from those of systemic lupus erythematosus. Treatment consists of discontinuing medications that cause exacerbation of the disease.
• Discoid (cutaneous). This form of pathology is characterized by the appearance of specific skin manifestations in the form of a “lupus butterfly”. However, laboratory and instrumental studies show no signs characteristic of SLE.
• Neonatal. Diagnosed in newborns whose mother suffers from systemic lupus erythematosus. Clinical signs of the disease disappear after 6 months without treatment. This is due to the cessation of circulation of maternal antibodies in the child’s blood.

Currently, diagnosing systemic lupus erythematosus is not difficult. The Yusupov Hospital carries out all types of diagnostic measures necessary to identify this autoimmune disease. The latest equipment allows you to accurately determine the localization of the pathological process and carry out appropriate treatment.

Forecast values

Lupus erythematosus is difficult to treat.

Very often the following picture of the development of the disease is observed:

• In complex types of the disease , which progresses very quickly over several years, complete damage to the internal organs occurs;
• With timely treatment, there is an 80% chance of getting rid of unpleasant symptoms;
• Once diagnosed, 60% of patients die due to infectious diseases;
• When affected during pregnancy, 60% of cases result in premature birth.

This type of disease does not go away without leaving a trace; even with timely treatment, a person may experience some disruptions in the functioning of the body.

It is easiest to cope with the disease in the first stages of its occurrence, otherwise it is necessary to undergo long and complex treatment.

Treatment of systemic lupus erythematosus

Due to the lack of exact causes causing systemic lupus erythematosus, there is currently no specific etiotropic treatment. The course of therapy is aimed at suppressing the mechanisms of development of CRS, as well as symptomatic relief of the symptoms of the disease. The main groups of drugs prescribed for systemic lupus erythematosus include:

1. Glucocorticosteroids.
2. Cytostatics.
3. Non-steroidal anti-inflammatory drugs.
4. Aminoquinoline drugs.
5. Biological products.

Prevention

To prevent the formation of lupus erythematosus, it is recommended to follow the following prevention methods:

• Maintain a balanced diet to ensure the intake of beneficial minerals and vitamins;
• Reduce the amount of time spent in the sun;
• Avoid stressful situations;
• To live an active lifestyle;
• Do not take hot water procedures;
• To refuse from bad habits;
• Avoid hypothermia;
• Do not take any medications without a doctor’s prescription;
• Complete all preventive procedures in a timely manner and eliminate all diseases.

Compliance with such methods allows not only to reduce the risk of developing symptoms of the disease, but also, if they do occur, to improve the overall well-being of the patient.

Glucocorticosteroids

They are among the most common and effective drugs for the treatment of systemic lupus erythematosus. Long courses of taking glucocorticosteroids significantly alleviate the general condition and reduce the severity of clinical signs. There are several ways to take medications. One of them is pulse therapy, in which a large dose of the drug is administered simultaneously. The dosage is individual and depends on body weight. The combined use of glucocorticosteroids and cytostatics is recommended. Indications for pulse therapy are:

• Rapidly developing lupus nephritis.
• Damage to the central nervous system.
• High disease activity.

Cytostatics

A group of anticancer drugs whose mechanism of action is to disrupt cell division. The main indications for the use of this group of drugs for systemic lupus erythematosus include:

• Ineffectiveness of taking glucocorticosteroids.
• High disease activity.
• Vasculitis.
• Presence of acute lupus nephritis.
• Carrying out pulse therapy in combination with glucocorticosteroids.

Nonsteroidal anti-inflammatory drugs

To reduce the activity of the inflammatory process and relieve pain, NSAIDs are prescribed. When body temperature rises, anti-inflammatory drugs are used as antipyretic therapy.

Aminoquinoline drugs

Systemic lupus erythematosus occurs with the development of photosensitivity. To reduce the severity of this symptom, aminoquinoline drugs are used. They have anti-inflammatory and immunosuppressive effects.

Biological products

Biological drugs are considered a promising development in the treatment of systemic lupus erythematosus. Medicines in this group have fewer side effects compared to glucocorticosteroids. Mass use of biological drugs is difficult due to their high cost.

In case of severe disease, extracorporeal therapy is performed. Her methods include:

• Plasmapheresis. The method of blood purification involves partial removal of plasma from the body. This reduces the number of antibodies that cause SLE.
• Hemosorption. Specific sorbents used in hemosorption purify blood outside the body.

The choice of treatment method depends on the stage of development of systemic lupus erythematosus. Specialists at the Yusupov Hospital provide a full course of therapy for autoimmune diseases, taking into account the individual characteristics of the pathology, as well as concomitant diseases. The clinic's rheumatologists have many years of experience in dealing with the manifestations of systemic lupus erythematosus, which helps to alleviate the condition and reduce the severity of clinical symptoms in the shortest possible time.

Historical reference

In 1828, the symptoms and signs of lupus were first described. After 45 years, dermatologist Kaposhi made another discovery. He noticed that with this disease, symptoms appear not only on the skin, but also affect the functioning of internal organs.

Scientists continued to study patients diagnosed with lupus erythematosus. What kind of disease this was became known in 1890. Researchers have suggested that this disease is asymptomatic and confirmed it with specific examples. If no pronounced changes are observed in the skin, the pathology can “eat up” the internal organs, thereby affecting important systems.

In 1948, there was another important breakthrough in the study of the disease. Doctors began to more carefully check the blood tests of infected people. As a result, so-called LE cells were discovered, that is, elements of lupus erythematosus. This analysis is actively used in medical practice today, which makes it possible to identify patients at an early stage.

In 1954, the most important discovery was made that helped explain the causes of the development of autoimmune disorders. Foreign proteins were identified in the blood of infected people that acted against healthy cells. Antibody testing has helped develop ultra-sensitive tests that allow early diagnosis of lupus disease.

Prognosis for life and complications

Systemic lupus erythematosus is an incurable disease, the treatment of which is limited to maintaining long-term remission. During the period of exacerbation, medications are prescribed to influence the mechanism of development of the disease, as well as symptomatic relief of the signs of SLE. The prognosis depends on the stage of detection of the disease. The earlier the pathology was diagnosed, the more favorable the prognosis for survival. A severe form of systemic lupus erythematosus with the development of multiple organ damage has an unfavorable prognosis and significantly reduces life expectancy. In order to minimize the number of relapses of the disease, there are preventive recommendations, which include:

• Regular visits to the doctor. The appearance of the first signs of exacerbation of the disease requires immediate consultation with a doctor for timely diagnosis and adjustment of therapy. During the period of long-term remission of SLE, scheduled consultations with the attending physician are necessary to conduct control studies.
• Strict adherence to recommendations for drug therapy. Glucocorticosteroids for SLE are taken on an ongoing basis. The dosage and frequency of administration are determined by the doctor based on previous diagnosis. It is forbidden to independently adjust the dosage of drugs; a complete refusal of therapy is excluded.
• Refusal of vaccinations and vaccinations.
• Maintaining a rational and balanced diet. Prevention of systemic lupus erythematosus requires limiting the consumption of salt, sweets, and flour products. Hot, spicy, smoked dishes are excluded from the diet. The daily menu should include a sufficient amount of protein.
• Limit exposure to direct sunlight. For additional skin protection on sunny days, you should use sunscreen.
• Elimination of overvoltage. A stressful situation or excessive physical activity can cause a relapse of systemic lupus erythematosus. It is recommended to follow a gentle regimen with proper rest.
• Selective use of medications. Autoimmune disease requires special attention to the choice of medications. Therefore, before taking the drug, you should consult your doctor.

Thanks to modern methods of treating systemic lupus erythematosus, the average life expectancy has increased. The five-year survival rate for diagnosed SLE is about 80-90%.

The severe course of the disease leads to the development of complications, which include multiple organ lesions:

• Kidney and liver failure.
• TELA.
• Ischemic or hemorrhagic stroke.
• Pulmonary edema, pleurisy, pulmonary hypertension.
• Intestinal gangrene.
• Internal bleeding of various locations.

Treatment of SLE in Moscow

Systemic lupus erythematosus requires timely diagnosis and correct treatment with the selection of ongoing therapy. You can undergo a full examination to identify systemic lupus erythematosus in Moscow in the Yusupov Hospital. The clinic is equipped with modern equipment that allows for a full range of diagnostic measures necessary to make an accurate diagnosis. Based on the data obtained, highly qualified staff of rheumatologists selects individual treatment in accordance with the stage of development of the disease. You can make an appointment with a doctor, as well as find out more about prices by phone or on the official website of the Yusupov Hospital.