pharmachologic effect
The active ingredient of the drug Vinoxin mv 30mg - Vincamine is of plant origin (alkaloid Vinca minor L. - small periwinkle), has a selective vasoregulatory effect on cerebral circulation, promoting its adaptation to the metabolic needs of the brain.
The drug Vinoxin MB improves metabolic processes in the brain by increasing the oxidative reactions of glucose, which helps to increase energy production in cells and enhance their overall activity.
Vinoxin MB is well tolerated by patients. Has no hematological and biological toxicity. Does not have a negative effect on the liver and kidneys. The drug is considered a promising drug for the correction of mental abilities.
Analogues of Oksibral
An analogue of Oksibral is the drug Vinoxin, which contains the same active ingredient, vincamine. Aminalon, Cavinton and other neurometabolic stimulants have a similar effect. Based on the nature of the effect, analogues of Oxibral can also include Nootropil and other drugs whose active substance is piracetam. However, unlike Oxybral, piracetam-containing drugs do not have a vasodilating effect on cerebral vessels.
Indications for use
The use of the drug Vinoxin MB is indicated for the normalization and adaptation of cerebral circulation in accordance with the metabolic needs of the brain: to improve, regulate and maintain brain functions in the following conditions:
- impaired concentration;
- atherosclerotic damage to cerebral vessels;
- after acute cerebrovascular accident;
- hypertensive encephalopathy;
- disturbance of orientation in space and time, emotional disturbances that are the consequences of various mental disorders;
- deterioration of memory and brain activity;
- diabetic angiopathy.
The medication is also effective for post-traumatic traumatic brain disorders, cerebral disorders after cerebral ischemia, and for hearing and vision disorders of vascular origin.
Indications for use of Oxibral
The use of Oxybral is indicated for all types of disorders or decreases in brain activity. According to the instructions, Oksibral is prescribed for the following indications:
- Drug rehabilitation after an ischemic stroke and as a preventive measure in the event of a threat of its development;
- Cerebrovascular insufficiency;
- Increased intracranial pressure;
- Hypertension, especially with a pronounced cerebral component;
- Migraine and migraine-like attacks;
- Attacks of dizziness of unknown origin;
- Deterioration in concentration and memory due to various pathologies (atherosclerosis of cerebral vessels, consequences of traumatic brain injury, consequences of brain surgery, diabetic angiopathy, etc.);
- As part of complex therapy for menopausal changes in women;
- Deterioration of speech, vision and hearing of vascular and neurological origin;
- As part of complex therapy in the treatment of mental illness;
- Decrease in intellectual abilities in older people;
- Underdevelopment of intellectual abilities in childhood and adolescence, including severe mental retardation.
There are reviews about Oksibral, confirming the advisability of its use in cerebral palsy, as well as for stimulating mental abilities when intense mental activity is necessary.
Contraindications
Tabletki Vinoxin MV should not be used in patients with hypersensitivity to any component of the drug.
Instructions for use Vinoxin notes the following conditions in which the use of this drug is prohibited:
- brain tumor (or diseases that cause increased intracranial pressure);
- seizure disorders;
- acute stroke;
- heart rhythm disturbance;
- severe electrolyte disturbances (hypokalemia or hypocalcemia).
The use of Vinoxin MR in pediatrics is contraindicated.
Instructions for use of Oxybral
Following the instructions, Oxibral is prescribed 1 capsule (30 mg) 2 times a day. The drug can also be prescribed in the form of intramuscular or intravenous injections, in this case the dosage for adults: 2 ampoules intramuscularly or intravenously in combination with an isotonic solution for infusion, twice a day.
It is recommended to use Oxibral in pediatric practice exclusively in the form of intramuscular injections or intravenous infusions, a single dose is 15 mg of the active substance (1 ampoule), 1 or 2 times a day as prescribed by a doctor.
The duration of therapy with this drug is determined in each case individually. Due to its good tolerability and lack of pronounced toxic effects, if indicated, long-term use is possible - up to a year.
Oxybral should not be used without a doctor's prescription.
Side effects
The drug Vinoxin MV may cause the following undesirable reactions when used:
From the cardiovascular system: prolongation of the QT interval, ventricular flutter-fibrillation.
From the immune system: hypersensitivity reactions, including angioedema.
From the skin and subcutaneous tissue: erythema, itching, allergic dermatitis, urticaria, papular rashes.
From the digestive system: nausea, heartburn, diarrhea, constipation, dry mouth.
From the nervous system: headache, dizziness.
Mental disorders: slight increase in mental activity.
Pharmacological properties of the drug Oxibral
Pharmacodynamics . Vincamine has a selective vasoregulatory effect on cerebral vessels, promoting the adaptation of cerebral blood flow to the metabolic needs of the brain. The drug improves brain metabolism by enhancing the oxidation of glucose, thereby increasing energy production and helping to increase the overall activity of the body. Vincamine increases the oxygen supply to neurons in a state of hypoxia. The drug reduces and stabilizes cerebral vascular resistance. Vincamine has the unique ability to normalize cerebral circulation and improve oxygen supply to neurons. It has been proven that the drug is well tolerated by patients, has no biological, hematological toxicity and no side effects on the kidneys and liver. Vincamine, having a diverse effect that increases the functional activity of the brain, is a promising drug for use as a stimulant of intellectual abilities. Pharmacokinetics . Rapidly absorbed from the gastrointestinal tract after oral administration, the half-life is 60–90 minutes, binding to plasma proteins is 64%. Vincamine is completely metabolized in the liver, only 4–6% is excreted unchanged in the urine.
Drug interactions
According to the instructions for use of Vinoxin MV, the combined use of the medication with drugs that can provoke ventricular flutter-fibrillation should be avoided. If this cannot be avoided, careful clinical and ECG monitoring is recommended.
A possible mechanism of interaction between itraconazole and vinca alkaloid is inhibition of cytochrome P450 by itraconazole. Itraconazole may also inhibit the P-glycoprotein pump responsible for the clearance of vinca alkaloid. Therefore, when using itraconazole and vincamine together, patients should be closely monitored.
The manufacturer of Vinoxin MV warns that it is necessary to avoid combined use of the drug with alcohol-containing drinks.
Composition and release form
Available in the form of an injection solution and capsules.
The solution (slightly yellowish or colorless) for injection is sold in ampoules of 2 milliliters. One ampoule of Oxybral contains 15 milligrams of vincamine and some excipients: tartaric acid, propylene glycol, sodium bicarbonate, sodium metabisulfite, purified water for injection. The drug is produced in blister packs of five ampoules, in cardboard boxes.
One capsule contains 30 milligrams of vincamine and auxiliary components: indigo carmine, blue sepsis, talc, erythrosine, shellac, gelatin, methacrylic acid copolymer, lactose, povidone, sucrose. They sell capsules in blisters of 20 pieces each.
Reviews and recommendations from doctors and patients
Doctors note that a feature of the drug Vinoxin MB is its prolonged action, which makes it possible to reduce the frequency of administration to 2 times a day, which, in turn, helps to increase adherence to therapy.
According to reviews from patients suffering from memory and attention disorders, pain, a feeling of heaviness and noise in the head, dizziness, sleep disturbance, increased fatigue, irritability, after taking the drug there is a noticeable relief of symptoms. Also, in patients with certain mental disorders caused by disorientation in space and time, as well as in persons with emotional disturbances, taking the drug helps improve their health.
Release form
Oxibral is available in the form of capsules and as a solution for injection.
Long-acting capsules, each containing microgranules of two colors - blue and white.
One capsule contains: vincamine (30g) and excipients: sucrose, lactose, povidone, methacrylic acid copolymer, shellac, gelatin, talc, erythrosine, blue sepsis, indigo carmine. The blister contains 20 capsules.
The solution for injection is available in ampoules of 2 ml, transparent, colorless or slightly yellowish. Each ampoule contains 15 mg of vincamine and excipients: propylene glycol, tartaric acid, sodium metabisulfite, sodium bicarbonate, tartaric acid, purified water for injection. The package contains 5 ampoules.
Side effects
According to numerous reviews of the drug, treatment is usually not accompanied by side effects. Oksibral has no biological and hematological toxicity, and also does not have a negative effect on the kidneys and liver.
In some cases, disorders of certain body systems may develop, which most often manifest themselves in the form of allergic reactions, skin rashes, decreased blood pressure and tachycardia.
Cases of overdose with the use of Oxibral have not been recorded.
special instructions
According to indications, the doctor may prescribe Oxibral simultaneously with other antihypertensive drugs and antiplatelet agents, and a mutual enhancement of the effect of the drugs is observed.
The medicine should be used with caution in patients after a heart attack and in patients with arrhythmias.
The use of Oxybral does not affect the ability to drive vehicles or perform hazardous types of work that require increased attention from the patient.
It is not recommended to exceed the dosages specified in the instructions, as well as the duration of use of the drug.
Release form and composition
Oxybral is produced in the following forms:
- Slow-release capsules (10 pieces in blisters, 1, 2 or 6 blisters per package);
- Syrup for oral administration (60 or 120 ml bottles);
- Solution for injection (2 ml in ampoules, 5 ampoules per package).
The drug contains the active substance – vincamine (Vinca minor alkaloid):
- 1 capsule – 30 mg;
- 5 ml syrup – 10 mg;
- 2 ml (1 ampoule) injection solution – 15 mg.
Special instructions for the use of the drug Oxibral
Do not exceed the recommended dose. Use with caution in patients with hypertension (arterial hypertension) and cardiac dysfunction. Do not use if the QT and there is hypokalemia. The drug contains lactose, which should be taken into account in case of hereditary lactose intolerance. during pregnancy and breastfeeding . Children . Oxibral capsules are not recommended for use in children. Does not affect the ability to drive vehicles and operate other mechanisms , but the state of the central nervous system should be taken into account.
Directions for use and dosage
For adults, Oxibral capsules, according to the instructions, can be taken regardless of meals. Single dosage – 30 mg (1 capsule), frequency of taking the medicine – 2 times a day, course duration – 2 months. According to indications, the doctor can change the frequency of use of the drug and the duration of the treatment course.
Also prescribed for adults:
- Syrup – 1-2 teaspoons three times a day;
- Intravenous drip or intramuscular injection - 15 mg up to 2 times a day.
Children over 6 years old are usually prescribed Oxybral in the form of syrup, 1/2 teaspoon three times a day. It is also possible to use it in the form of an injection solution - intravenously or intramuscularly - 7.5 mg 2 times a day.
