Thermikon for nail fungus: release forms, instructions for use

Compound

Thermikon tablets contain the active ingredient terbinafine .
Excipients: hypromellose, sodium starch glycolate, milk sugar, MCC, magnesium stearate, aerosil. Thermikon spray includes terbinafine hydrochloride . Excipients: proxanol 268, ethanol, propylene glycol, prepared water.

The cream contains terbinafine hydrochloride .
Excipients: sodium hydroxide, phenylcarbinol, cetyl palmitate, octadecyl alcohol, sorbitan monostearate, ethyl, isopropyl myristate, polysorbate 60, prepared water.

In cases of impaired renal and liver function

The effect of the drug, if the patient has detected renal or liver failure, must be monitored by a doctor, with regular tests and examinations. Patients with chronic pathologies of the kidneys or liver are prescribed half the dose - the spray is applied to the skin once every other day. If the test parameters deteriorate, the Thermikon spray should be discontinued immediately.

Pharmacodynamics and pharmacokinetics

Terbinafine acts on fungal cell processes by causing inhibition of squalene epoxidase, which is a fungal enzyme that promotes the synthesis of ergosterol . This leads to loss of enzyme activity and suppression of the synthesis of the main substance of the fungal cell membrane. The action of Thermikon is fungicidal against microorganisms sensitive to it, since it is characterized by a wide spectrum of antifungal effect. Sensitivity to this drug is shown by: Epidermophyton floccosum, which is the causative agent of epidermophytosis ; Microsporum canis is a known causative agent of mycosporia ; Trichophyton spp., causing trichophytosis , as well as dermatophytes , aspergillus, scopulariopsis, candida, cladosporium and the causative agent of pityriasis rosea .

Specifics of action

The main component of the drug is terbinafine. It prevents the proliferation of fungus and destroys existing microorganisms, making changes to their cellular structure.

Thermikon tablets contain 250 mg of active substance. Available in 7, 14 or 28 pieces per package. Used to treat advanced stages of fungal infections. After 4-5 hours, half of the taken dosage is evenly distributed throughout all tissues and organs of the body. It is well adsorbed, so the effect of the product does not depend on food intake.

Thermikon spray is available in bottles of 15 and 30 g. The main component of the drug is hydrochloride. Used for both therapeutic and prophylactic purposes.

Thermikon cream is the most common type of drug for topical use. 1 g of product contains up to 10 mg of terbinafine hydrochloride. The cream is well absorbed and penetrates into the deepest layers of the skin and nail plates. It tends to accumulate in hair follicles and subcutaneous retina.

About 80% of the drug is excreted from the body with urine, the remaining part is excreted with feces.

Several forms of release of Thermikon allow the medicine to be used to treat many fungal diseases. Indications for use of the drug are as follows:

• fungal infections of the scalp;
• mycoses of the skin (more details);
• onychomycosis (nail lesions);
• candidiasis of the mucous membranes and skin;
• candida of different localization;
• lichen.

Fungal infections of the scalp

Mycoses of the skin

Candidiasis of the mucous membranes

Candidiasis of the skin Candida of the reproductive system

Lichen

Indications for use

The drug in tablet form is prescribed only in severe cases, and also when previous therapy with external agents has proven ineffective.

Tablets are recommended for the treatment of:

• trichophytosis;
• athlete's foot inguinal;
• microsporia;
• onychomycosis;
• candidiasis of the skin and mucous membranes;
• dermatomycosis of the skin with a complicated course.

Indications for the use of cream and spray are:

• mycoses of the feet;
• pityriasis versicolor;
• mild inguinal athlete's foot
• fungal infections of smooth skin and some parts of the body;
• the risk of infection with certain fungi - for the purpose of prevention.

Overdose symptoms

In case of overdose of tablets, gastric lavage is recommended

When used externally, an overdose is unlikely. Symptoms of taking large doses of the drug in tablets:

• dizziness;
• migraine;
• nausea;
• vomit;
• stomach ache.

In case of overdose, you should rinse your stomach and drink the sorbent. If necessary, symptomatic treatment is carried out.

Contraindications for use

It is not recommended to use Thermikon for:

• lactation, pregnancy;
• fungal infections in children less than 3 years old, weighing up to 20 kg;
• sensitivity to the drug.

During treatment, patients with:

• liver failure;
• alcoholism;
• renal failure;
• tumors;
• bone marrow pathologies that inhibit hematopoiesis;
• metabolic disorders;
• diseases with occlusion of blood vessels of the extremities.

Symptoms of nail fungus, or When should you take the drug?

The main signs of a disease such as nail fungus are the following symptoms:

• Change in nail color. A person’s nails may completely lose their inherent pink tint along with their healthy shine. They often lose their transparency, becoming cloudy and, in addition, colorless. Under the influence of the disease, the nail plates may turn yellowish, white, grayish, or sometimes even acquire a brownish tint.
• The structure and shape of the nail may change. In this case, the surface of the nails, as a rule, becomes ribbed and uneven. Due to damage to the tissue located under the nail plate, thickening and deformation of the nails occurs. Due to the influence of infection, nails can become very thick, so much so that they are difficult to trim. Very often, with fungal infections, nails can take on a strange, and at the same time, unusual shape. Because of all this, discomfort and pain are likely when walking.
• Loss of strength. Due to a fungal disease, nails can become very fragile and easily crumble or break.
• Change in height. Tissue affected by the fungus usually grows much more slowly.

The skin that surrounds the nail can also become infected with fungus. It can often become red or inflamed. If a person suspects that he has nail fungus, it is advisable to use Termicon tablets for nail fungus, since this remedy is now very effective against such infections. But before using it, you need to discuss treatment with your doctor, and also find out the causes of the infection.

Side effects

When treated with Thermikon, deviations such as anorexia , agranulocytosis , dyspepsia , myalgia , diarrhea , arthralgia , nausea , urticaria stomach pain , thrombocytopenia , rash , change in taste , Lyell's syndrome , neutropenia , cholestatic jaundice and more may occur.

Side effects during use

The use of the presented drug may be accompanied by various side effects, among which the following symptoms and conditions may be observed:

• The occurrence of anorexia, agranulocytosis, dyspepsia or myalgia.
• The appearance of diarrhea, arthralgia, nausea or urticaria.
• The occurrence of stomach pain.
• Development of thrombocytopenia.
• The appearance of a rash on the skin.
• Presence of taste perversion.
• Development of Lyell's syndrome.
• Temporary loss of ability to perceive taste.
• Development of cholestatic jaundice.

This drug has many contraindications. In this regard, one should take into account cases in which taking these tablets can only cause harm. So, let’s find out when you shouldn’t take Thermikon tablets for fungus.

Instructions for use of Thermikon (Method and dosage)

As the instructions for use of the tablets show, standard dosages can be half or a whole tablet, which is taken once a day. Treatment can last 1-12 weeks. It is recommended to take the medicine after meals.

The duration of treatment directly depends on the disorder, for example, with interdigital dermatomycosis it can reach 4-6 weeks, with plantar dermatomycosis - 2 weeks, with mycosis capitis - 4 weeks, and so on.

Cream and spray are intended for external use. These products can be applied to the affected areas and surrounding tissues. The ointment is distributed in a thin layer and rubbed in gently. The spray is pre-sprayed and then lightly rubbed in. External forms are recommended for use every day 1-2 times. Before use, the skin is well dried and cleansed. The course of treatment is 4 weeks. On average, treatment of ringworm of the trunk or lower leg, lichen versicolor , and ringworm of the feet is carried out within 7 days.

Additional information and recommendations

Violation of the treatment regimen, along with an unauthorized reduction in the course of therapy, can provoke relapses of the pathology. The duration of treatment is strictly individual. The decision to extend the standard course is made by the doctor, who assesses the patient’s condition and the presence of concomitant pathologies. The therapeutic response in the treatment of onychomycosis may develop delayed, on average this occurs after several months.

Nail removal may not be necessary if the course of treatment was chosen correctly and fully corresponds to the current disease. For example, with onychomycosis of the hands, three weeks of treatment are required, and in case of damage to the feet, therapy will take twice as long.

If symptoms of liver damage appear, and in addition, against the background of the development of an allergic reaction, this drug is discontinued. During treatment, monitoring of liver enzyme levels is indicated. The drug "Thermikon", due to the extremely active main component terbenafine, is theoretically capable of causing an exacerbation of psoriasis.

During treatment, it is necessary to simultaneously thoroughly treat shoes and clothing that have been in contact with the area affected by the fungus. Things are treated with special antifungal agents. The presented drug does not affect a person’s concentration in any way.

What else does the instructions for use for Thermikon tablets tell us?

Interaction

The simultaneous use of Thermikon can slow down the metabolism of desipramine , tricyclic antidepressants , fluvoxamine , Metoprolol , Propafenone , flecainide , Propranolol , Chlorpromazine and Haloperidol , and reduce the clearance of terbinafine. MAO inhibitors increase the elimination of terbinafine.

Suppression of the biotransformation of terbinafine and an increase in its plasma concentration is observed in combination with histamine receptor antagonists . The combination with Rifampicin accelerates the elimination of terbinafine by 2 times, and Cimetidine , on the contrary, slows it down.

The simultaneous use of Thermikon with oral contraceptives often causes menstrual irregularities. Combination with hepatotoxic drugs increases mutual toxicity aimed at the activity and condition of the liver.

special instructions

Tablet forms of the drug often cause side effects.

From the gastrointestinal tract:

1. nausea;
2. stool disorders;
3. lack of appetite;
4. disruption of taste buds;
5. feeling that the stomach is full.

From the musculoskeletal system and muscle tissue:

• myalgia;
• arthralgia.

From the blood circulation side:

1. thrombocytopenia;
2. neutropenia.

Thrombocytopenia

Neutropenia

In case of an overdose, signs of poisoning appear: dizziness, vomiting, abdominal pain. To eliminate symptoms, gastric lavage and taking adsorbents are required.

When using topical agents, an allergic reaction is possible. There have been no cases of overdose when using ointment and spray.

The drug is prescribed extremely rarely to patients diagnosed with psoriasis, since the components included in the drug cause an exacerbation of the disease.

The drug should not be used in the following cases:

• individual intolerance to the components of the product;
• children under 3 years of age (cream and spray are not used for children under 12 years of age);
• the child’s weight does not reach 20 kg;
• breastfeeding period;
• pregnancy.

Thermikon's analogues

Level 4 ATX code matches:
Mikonorm

Undecin

Gentian violet

Zinkundan

Exoderil

Exiter

Batrafen

Lotseril

Lamisil Dermgel

Lamisil Uno

Lamisil

Salicylic acid

Salicylic ointment

Keto Plus

Exifin

Fungoterbin

Mycoseptin

Nitrofungin

Sulsena

Baziron AS

In pharmacology, there are many analogues of this drug, for example:

• Exiter
• Lamisil Uno
• Terbinafine hydrochloride
• Lamisil
• Binafin
• Atrifin
• Lamicon
• Mycoterbin
• Onyhon
• Mikonorm
• Tebicourt
• Turbix
• Terbinafine Pfizer
• Terbizil
• Terbinox
• Tsidokan
• Tigal-sanovel
• Fungoterbin
• Lamiter
• Terbifin
• Mikoter
• Lamifast

What does Thermikon ointment help with?

The main indication for Termicon therapy is infectious skin lesions of fungal origin. The local remedy copes well with acute pathologies and chronic indolent diseases. The cream is included in therapeutic regimens when pathogenic fungi sensitive to terbinafine are detected. It is prescribed to patients diagnosed with the following mycotic infections:

• pityriasis versicolor is a superficial fungal pathology of the skin belonging to the group of keratomycosis;
• mycoses complicated by acute or chronic inflammatory process;
• dermatomycosis localized in the foot area;
• epidermophyton - diseases characterized by damage to the upper layers of the skin by fungi of the genus epidermophyton;
• mycoses, localized mainly in the folds of the skin, between the fingers and toes.

Mycoses, dermatophytes and other diseases

Thermikon is used not only for medicinal purposes, but also for preventive purposes. The need to use the cream arises when there is a sharp decrease in immunity due to a bacterial infection. The weakening of protective forces leads to the activation of fungi belonging to opportunistic microflora. In such cases, the use of a fungiostatic agent becomes a good prevention of the development of mycoses.

The drug is used in the treatment of mycoses of the feet, affecting the skin and nails. It quickly destroys fungi in both the dermis and epidermis. But the remedy will not be able to completely cure damaged nail plates. This requires the use of varnishes and solutions, the ingredients of which can accumulate in the nail.

Reviews about Thermikon

Basically, reviews of Thermikon tablets are related to the treatment of complicated mycoses of the skin of the feet or lichen versicolor . Indeed, therapy with this form of the drug is prescribed when external agents have not brought the desired effect.

There are also reviews of Thermikon spray, in which the patient talked about its use during the treatment of candidiasis . From this message it becomes clear that timely initiation of therapy with mandatory observance of personal hygiene rules and the use of additional means can quickly eliminate this disorder.

In addition, as reviews of Thermikon ointment show, this remedy is actively used in the treatment of various fungal infections . It has been established that at the initial stage, Thermikon ointment exhibits the highest activity.

As you know, fungal diseases are one of the most common. Many people cannot immediately understand that they have mycosis. Moreover, even after the manifestation of unpleasant symptoms, some patients do not rush to see a doctor, trying to restore health by self-medication. When starting to take this drug, some people don’t even know exactly what the ointment is for and how it differs from its analogues. In order not to harm your health, drugs of this type can only be used as prescribed by a doctor.

Similar medications

"Thermikon" has in its arsenal analogues of various release forms. These can be not only tablets, but also creams or ointments. All of these medicinal analogues of Thermikon tablets are united by one common active ingredient and differ in their targeted effect on fungal infections. The use of certain drugs, as a rule, is resorted to in cases of adverse reactions. So, most often, doctors advise changing the drug we describe to such drugs as Atifin along with Lamisil, Binafin, Terbizil, Fungoterbin, Zalain or Bramisil. Cheap analogues of Thermikon tablets can be purchased at any pharmacy.

Thermikon price, where to buy

The price of Thermikon tablets containing 250 mg of active substance varies between 500-900 rubles, depending on the number of tablets in the pack.

The price of Thermikon spray for external use 1% is 300-500 rubles.

The price of Thermikon ointment for external use 1% can be approximately 350 rubles.

• Online pharmacies in RussiaRussia

ZdravCity

• Thermikon antifungal spray terbinafine 1%, 30 gPharmstandard-Leksredstva OJSC RUB
  439 order
• Thermikon antifungal cream terbinafine 1%, 15 g Pharmstandard-Tomskkhimpharm OJSC/Lekko ZAO

  RUB 302 order

• Thermikon antifungal terbinafine 250 mg tab. 14 pcs. Pharmstandard-Leksredstva OJSC

  RUR 535 order

• Thermikon antifungal terbinafine 250 mg tab. 28 pcs. Pharmstandard-Leksredstva OJSC

  830 rub. order

Pregnancy and lactation

It should be noted that currently the experience of using this drug during pregnancy is extremely limited, and therefore its use during pregnancy is strictly contraindicated.

The active substance of the drug, terbinafine, can be excreted in breast milk; therefore, if there is a need to prescribe this drug during lactation, the issue of stopping breastfeeding will have to be resolved.

In the course of experimental studies, the teratogenic properties of terbinafine were not identified. To date, there have been no reports of malformations associated with the use of terbinafine.

Such information is contained in the instructions for use for Thermikon tablets.

The drug today is a fairly popular remedy that people prefer to use to treat nail fungus. So, let's find out what consumers write in their comments about the use of this medicine and what they think about its effectiveness.