Pharmacodynamics and pharmacokinetics
Is Unidox Solutab an antibiotic or not?
The active ingredient of the drug, doxycycline , is an antibiotic from the tetracycline group. It inhibits the activity of pathogenic bacteria, affecting the ribosomal membranes in the cell. It does not allow the processes of RNA synthesis of some organisms to occur.
The medicine is active against such gram-positive bacteria as Streptococcus haemolyticus, Streptococcus viridans, Listeria spp, Streptococcus faecalis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epidermidis.
The drug inhibits the vital activity of gram-negative bacteria : Bacillus anthracis, Neisseria meningitidis, Brucella spp., Escherichia coli, Neisseria gonorrhoeae, Haemophilus influence, Clostridium spp., Salmonella spp., Pasteurella spp., Enterobacter spp., Entamoeba., Shigella spp. etc.
Doxycycline is also used to treat diseases caused by Mycoplasma spp., Rickettsia spp., Chlamydia spp. and Spirochaeta spp. .
Doxycycline is absorbed from the gastrointestinal tract. Within 2 hours after administration, it can be detected in almost all tissues of the body (teeth, saliva), with the exception of cerebrospinal fluid .
About half of the drug is excreted by the kidneys, the rest through the gastrointestinal tract. The drug can be detected in blood plasma after 19 hours with a single dose and after 48 hours during a course.
During pregnancy
While pregnant, any antibiotics are contraindicated. Tablets can be prescribed during pregnancy if the expected benefit to the mother from their use outweighs the risks to the fetus. During lactation, breastfeeding should be stopped when taking bactericidal capsules. After completion of treatment, the drug will be eliminated from the body after 7-8 days. According to the instructions, breastfeeding can be resumed on days 9-10.
Indications for use
What are Unidox Solutab tablets for?
The drug is prescribed for the treatment of diseases caused by microorganisms sensitive to doxycycline :
- ENT diseases ( otitis, tonsillitis , etc.);
- respiratory tract diseases ( pharyngitis, tracheitis, lung abscess , acute and chronic bronchitis );
- cystitis, prostatitis, pyelonephritis, urethritis, endometritis;
- PPI – for ureaplasma, syphilis, gonorrhea, chlamydia ;
- infections of the gastrointestinal tract - cholera, cholecystitis, gastroenterocolitis, diarrhea, yersiniosis ;
- trachoma, sepsis, peritonitis, osteomyelitis;
- prevention of malaria and postoperative suppuration.
What else does Unidox Solutab treat?
Yaws , rickettsiosis , legionellosis , Q fever , , first stage Lyme disease, Rocky Mountain spotted fever, tularemia , actinomycosis , plague , malaria , psittacosis , leptospirosis , psittacosis , bartonellosis , anthrax , whooping cough , granulocytic ehrlichiosis, bru cellosis, acne rash .
Contraindications
When prescribing Unidox, doctors need to take into account contraindications for use. This will help avoid troubles during treatment. The drug is contraindicated for use in the following cases:
- intolerance to Solutab components;
- renal dysfunction;
- stomach diseases with vomiting, diarrhea;
- leukemia;
- mononucleosis;
- allergies to this series of antibiotics;
- changes in liver function;
- pregnancy;
- lactation;
- intestinal ulcers;
- up to 8 years of age.
Side effects
- nausea, vomiting, loss of appetite, enterocolitis , inflammation in the genital area, due to increased growth of the fungus Candida , stomatitis ;
- dermatitis, urticaria, anaphylaxis, pericarditis and erythema ;
- renal and liver failure , albuminuria , lack of potassium in the blood, increased nitrogen levels in the blood plasma;
- anemia, porphyria, thrombocytopenia;
- tinnitus, hallucinations;
- fragility of bones and teeth, discoloration of enamel;
- hyperemia, anaphylactic shock, decreased blood pressure, tachycardia, difficulty breathing.
Instructions for use Unidox Solutab (Method and dosage)
The duration of use and dosage of the drug should be prescribed by a doctor, depending on the disease and its course. The tablets are swallowed whole or crushed into powder and mixed with water.
According to the instructions for Unidox Solutab, adults are prescribed 0.2 g of doxycycline per day (the first day), in one or two doses. In subsequent days, the dosage can be reduced to 0.1 g, at the discretion of the attending physician.
For gonorrhea, syphilis and other serious STDs, the daily dose is usually 0.3 g. Tablets are taken for 5-10 days.
For children (from 8 years old), if their weight is less than 50 kilograms, the calculation is based on the principle of 0.004 g of antibiotic per 1 kg. Or half as much at the end of the first day of use.
When not to use the product
Before answering this question, it is necessary to find out what negative effects this antibiotic has. According to studies, doxycycline accumulates in bone tissue, thereby forming insoluble compounds with calcium. Because of this, Unidox Solutab tablets are contraindicated during pregnancy and breastfeeding. They are also not recommended for children under eight years of age, when the little person’s skeleton is actively developing and molars appear.
Also, the antibacterial agent cannot be used in treatment if a person is allergic to tetracyclines or any other component included in the medication.
In addition, leukopenia, porphyria and serious disorders of the kidneys or liver are clear contraindications to the use of the drug.
How should an antibiotic be taken to achieve the desired effect?
Interaction
Taken together with magnesium-containing laxatives, iron preparations, sodium bicarbonate, calcium, magnesium and aluminum should occur at least 3 hours after the antibiotic.
The drug reduces the effectiveness of antibiotics such as penicillin and cephalosporin .
The medicine may cause a decrease in the prothrombin index and the effectiveness of hormonal contraceptives . Also, when taken simultaneously with retinol, in intracranial pressure may be observed .
The concentration of doxycycline in the blood will decrease if you combine the drug with ethanol, rifampicin, phenytoin, barbiturates and carbamazepine .
Analogues of Unidox Solutab
Level 4 ATC code matches:
Vibramycin
Doxycycline hydrochloride
Doxycycline
Olethetrin
The most common analogues: Vibramycin D, Doxibene, doxycycline hydrochloride, tetracycline hydrochloride, Doxa-M-Ratiopharm, Doxycycline, Tigacil . The price of analogues differs significantly from the original, most often it is lower.
Doxycycline or Unidox Solutab - which is better?
The main difference between the drugs is the fact that Unidox does not have such a strong effect on the stomach and does not cause side effects characteristic of doxycycline ( stomach ulcer, gastritis ). Absorption of the active substance occurs in the intestines and almost 100% of the medicine is absorbed by the body. The only advantage of doxycycline is its extremely low cost compared to the original.
What is the difference between Unidox and Unidox Solutab?
The prefix “solutab” in the name of the drug means that the tablet can be crushed and dissolved in water to prepare a suspension for administration. This method of taking the medicine is preferable for children.
special instructions
The instructions cover important points related to the use of the antibiotic. Following the instructions will speed up your recovery. Need to consider:
- long-term use of Solutab provokes dysbacteriosis and hypovitaminosis;
- the use of tetracycline antibiotics in patients with impaired renal function requires medical supervision;
- taking Unidox does not affect the ability to drive a car;
- To avoid the development of photodermatitis during the treatment period, you should not be in the sun or use a solarium.
During pregnancy
What is the danger of doxycycline for women? The substance passes into breast milk and through the uteroplacental barrier. The use of Solutab is contraindicated during the period of feeding a newborn. If treatment is necessary, the baby is transferred to formula. The ban also applies to the period of waiting for the child. Unidox during pregnancy causes serious disturbances in the development of fetal bone tissue.
Reviews about Unidox Solutab
Reviews in gynecology . The drug has good reviews in the treatment of gynecological diseases, for example chlamydia . Patients who were prescribed the drug for chlamydia note that the antibiotic is easily tolerated and effective. Although sometimes side effects occur in the form of headaches and disruption of the digestive system.
Reviews for use against ureaplasma are also good, many are of the opinion that the drug is almost the only effective way to get rid of the disease.
Reviews of Unidox Solutab for acne . Sometimes a dermatologist may prescribe antibiotics to treat acne. For most patients, acne medication helps, but then other problems arise due to the medication's side effects. For many, following a therapeutic diet helped better than those taking an antibiotic.
What patients say
Many patients note the effectiveness of tablets in the treatment of such serious diseases as ureaplasma, chlamydia, tonsillitis, pneumonia, cystitis and even purulent acne. However, very often consumers note in their reviews that they suffered from side effects of the antibiotic. For example, patients were worried about nausea, headaches, intestinal problems and other solvable problems.
It is very rare to find reviews that the drug was not suitable for patients, or that it turned out to be ineffective at all. Although such cases are also possible, because Unidox Solutab is not a universal remedy that is completely suitable for treating all people without exception.
Regarding the rules for taking the drug, patients are advised to take it strictly according to the instructions and in accordance with the recommendations of doctors. People also recommend combining the use of this antibiotic with probiotics so as not to cause irreparable harm to the intestines. Moreover, patients are strongly advised to take tablets after meals, and not on an empty stomach, as this can provoke severe attacks of nausea and vomiting. Also, many have noticed that the antibiotic we are interested in lowers immunity. Moreover, there is an opinion that it is an outdated medicine and, in addition, can cause temporary infertility.
Therefore, it’s up to you to decide whether to take Unidox Solutab or not.
When making a decision, you should not pay attention only to consumer reviews
It is important to listen to the opinion of a doctor who has experience and inspires confidence, and follow the recommendations of a specialist
Unidox Solutab price, where to buy
The average price of tablets in Ukraine is 80 UAH for 10 pieces. How much does medicine cost in Kyiv? The price of 100 mg of doxycycline (10 tablets) contained in the drug will be about 90 UAH. The cost of the same amount of the drug in Kharkov will be about 115 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Unidox Solutab dispersible tablets 100 mg 10 pcs. ZiO-Zdorovye ZAO
302 rub. order - Unidox solutab dispersant tablets. 100 mg 20 pcs. ZiO-Zdorovye ZAO
RUR 575 order
Pharmacy Dialogue
- Unidox solutab tablets 100 mg No. 10ZiO-Zdorovye CJSC
RUB 352 order
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Pharmacy24
- Unidox Solutab 100 mg N10 tablets Astellas Pharma Europe B.V., Netherlands
141 UAH.order
PaniPharmacy
- Unidox solutab tablets Unidox salutab tablets. 100 mg No. 10 Netherlands, Astellas Pharma Europe
152 UAH order
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