Airtal, 100 mg, film-coated tablets, 20 pcs.

Pharmacological properties of the drug Aertal

Pharmacodynamics. Aceclofenac has anti-inflammatory, analgesic and antipyretic effects.
Aceclofenac, by inhibiting the synthesis of prostaglandins, affects the pathogenesis of inflammation, the occurrence of pain and fever. In rheumatic diseases, the anti-inflammatory and analgesic effect of aceclofenac helps to significantly reduce the severity of pain, morning stiffness, swelling of the joints, and improves the patient's functional state. Pharmacokinetics. Aceclofenac is quickly and completely absorbed after oral administration. The maximum concentration in blood plasma after oral administration is achieved after 1.25 - 3 hours. 99% of aceclofenac binds to blood plasma proteins, mainly albumin. Aceclofenac penetrates into the synovial fluid, where the maximum concentration reaches 57% of the concentration level in the blood plasma, and the time to reach the maximum concentration is 2 to 4 hours later than in the blood plasma. Distribution volume - 25l. The half-life is 4 hours. Aceclofenac is in the systemic circulation in an unchanged state, its main metabolite is 4-hydroxyaceclofenac. Approximately 2/3 of the administered dose of the drug is excreted in the urine in the form of hydroxy derivatives.

What does it consist of?

Medicine for pain is available in several forms:

• powder from which it is easy to prepare a suspension;
• pills;
• cream.

The powder is available in a dosage of three grams. Typically sold in packs of twenty bags.

Tablets of one hundred milligrams, sold in packs of twenty and sixty tablets. Uniform white ointment in a sixty gram package.

The main active ingredient is aceclofenac.

Side effects of the drug Airtal

From the gastrointestinal tract: nausea, vomiting, epigastric pain, intestinal colic, dyspepsia, flatulence, anorexia, constipation; in rare cases, erosive and ulcerative lesions, bleeding and perforation of the gastrointestinal tract have been observed. From the side of the central nervous system: sometimes there is headache, dizziness, sleep disturbance (insomnia or drowsiness), agitation, in some cases - sensory disturbances, disorientation, memory loss, visual impairment, hearing impairment, taste disturbances, tinnitus, convulsions, irritability, tremor. , depression, aseptic meningitis. Allergic reactions: sometimes a skin rash occurs, rarely - urticaria, eczema, erythema multiforme, erythroderma, asthma, systemic anaphylactoid reactions, in some cases vasculitis, pneumonitis, Stevens-Johnson syndrome and Lyell's syndrome. From the kidneys: rarely - peripheral edema, very rarely - acute renal failure, interstitial nephritis, nephrotic syndrome, hematuria, proteinuria. From the liver: transient increase in the activity of liver transaminases, rarely - hepatitis, in some cases fulminant hepatitis. From the hematopoietic system: very rarely - thrombocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia. From the cardiovascular system: isolated cases of tachycardia, hypertension (arterial hypertension), congestive heart failure.

Who should not be prescribed

"Aertal" is contraindicated in the following conditions:

• peptic ulcer of the stomach and duodenum;
• gastritis in the acute phase;
• allergic manifestations;
• poor blood clotting;
• liver diseases;
• kidney inflammation;
• heart failure;
• minor patients;
• pregnancy.

The ointment is not used for external skin lesions, as well as allergic rashes.

Special instructions for the use of the drug Airtal

The drug is prescribed with caution to patients with a history of diseases of the liver, kidneys, gastrointestinal tract, asthma, allergic (hay) rhinitis, polyposis rhinitis, dyspeptic symptoms at the time of drug administration, hypertension (arterial hypertension), heart failure, after extensive surgery, in I and second trimesters of pregnancy and during lactation, as well as for elderly patients. During administration of the drug, it is necessary to systematically monitor the composition of peripheral blood, liver and kidney function, and examine stool for occult blood. Patients who use the drug must refrain from engaging in activities that require increased attention and speed of psycho-motor reactions, as well as from drinking alcohol.

Aertal or Xefokam: which is better?

Ksefokam, like Airtal, is an anesthetic drug. Its activity is primarily observed in rheumatoid arthritis, osteoarthritis and other types of joint and bone pain. However, unlike Airtal, Xefocam is based on another active substance - lornoxicam, which does not in any way affect the level of inflammation and the patient’s body temperature. The drug is suitable for symptomatic use and relief of sudden pain.

Adverse reactions for both drugs are identical. Long-term use can cause anemia, thrombocytopenia, insomnia, and depression. When choosing between medications, you need to pay special attention to individual intolerance to the components, and the need to relieve inflammation and normalize the temperature.

Both drugs are contraindicated during pregnancy and breastfeeding, since their active ingredients are instantly and almost completely absorbed into the blood. These drugs are also not prescribed to patients under 18 years of age. Bronchial asthma is a direct contraindication to the use of both drugs, since both of them can cause bronchospasm.

Interactions of the drug Airtal

The following interaction effects are observed when taking Aertal simultaneously with other drugs:

• increases the plasma concentration of digoxin, fentonyl and lithium preparations;
• reduces the effect of diuretics and antihypertensive drugs;
• when used with potassium-sparing diuretics, it can cause hyperkalemia;
• increases the risk of side effects from the gastrointestinal tract when used simultaneously with other NSAIDs or glucocorticoids;
• acetylsalicylic acid reduces the concentration of aceclofenac in the blood plasma;
• cyclosporine enhances the toxic effect of aceclofenac on the kidneys;
• with hypoglycemic drugs, hypo- or hyperglycemia is possible (monitoring of blood glucose levels is necessary);
• increases the concentration level of methotrexate and enhances its toxic effect;
• When used with indirect anticoagulants, constant monitoring of the coagulogram is required.

What is Aertal powder from?

Powder is a type of dosage form. It is intended for preparing a suspension. A single dose of the drug is packaged in a sachet. The advantage of using the powder is its rapid absorption. The tablet requires time to be broken down and processed in the gastrointestinal tract, and the powder, once in the stomach, begins to be absorbed into the blood without waiting for delivery to the intestines. The active substance contained in the tablets is contained in the same volume in one sachet.

Another advantage of using powder is the ability to accurately adjust the dose. For example, people with kidney or liver failure need to reduce the single dose by half. By dividing the contents of the package into two parts, it is easy to prepare a suspension of the desired concentration.

How to take it

The tablets are taken orally and must be taken with meals. Otherwise, stomach problems will arise. Drink with plenty of water. For severe pain, take it once in the morning and once in the evening. If the pain is periodic, take it once.

If you have kidney failure, you should not take this drug without a doctor's supervision. The doctor must assess the patient's condition, the results of glomerular filtration tests and calculate the correct dose. Otherwise, serious complications are possible.

The powder is diluted with water in the indicated dosage and taken orally twice a day. Sometimes patients prefer the drug in liquid form.

The ointment is rubbed into the affected areas of the body three times a day. Squeeze out the cream the size of a pea (two grams).

In case of overdose, increased side effects occur. You need to stop taking it, drink activated charcoal and call for medical help.

Indications for use

Airtal is widely used in neurological practice to eliminate pain and inflammation in the following diseases:

• Vertebrogenic cervicalgia, cervicocranialgia, lumbodynia, thoracalgia, lumboischialgia, etc.
• With concomitant articular syndrome, to alleviate the general condition and clarify the clinical picture.
• As an additional remedy in the treatment of pain syndrome with facial neuritis, herpetic ganglioneuritis, trigeminal neuralgia.
• As a means to relieve a migraine attack.

Directions for use and dosage

Airtal film-coated tablets are intended for oral use and should be taken with at least ½ glass of liquid. Airtal is preferably taken with food.

Airtal, powder for oral suspension, is intended for oral use. Dissolve the contents of 1 packet in 40–60 ml of water and take immediately. Simultaneous food intake slows down the rate of absorption of the active substance, but does not reduce the degree of absorption in the gastrointestinal tract. Airtal, powder for oral suspension, is preferably taken with food.

Adverse events can be minimized by using the minimum duration of drug use necessary to control symptoms.

Adults. The maximum recommended dose is 200 mg/​day in 2 divided doses of 100 mg (1 tablet/​package in the morning and 1 tablet/​package in the evening).

Elderly patients. The condition of such patients should be carefully monitored, since they are more likely to have impaired renal function, liver function, and cardiovascular disorders, and such patients are more likely to receive concomitant therapy for other diseases, which increases the risk of developing serious adverse reactions.

If it is necessary to prescribe NSAIDs, the latter should be used in minimal doses and for the shortest possible time. As a rule, no dose reduction is required. Patients should be carefully monitored for timely detection of gastrointestinal bleeding during NSAID therapy, and also adhere to the recommendations described in the SPECIAL INSTRUCTIONS section.

Liver failure. For patients with mild or moderate hepatic impairment, the dose of aceclofenac should be reduced. The recommended starting dose is 100 mg/​day.

Kidney failure. There is no information that patients with mild renal failure require dose adjustment of aceclofenac, however, caution should be exercised when using the drug in this category of patients.

Contraindications

Aceclofenac is contraindicated in the following categories of patients:

• with hypersensitivity to aceclofenac or any auxiliary component of the drug;
• in whom acetylsalicylic acid or NSAIDs cause asthma attacks, acute rhinitis, angioedema or urticaria, as well as hypersensitivity to these drugs;
• with a history of gastrointestinal bleeding or ulcer perforation associated with previous NSAID therapy;
• with the presence of concomitant peptic ulcer or bleeding currently or in history (2 or more separate proven episodes of ulcer or bleeding);
• with acute bleeding or diseases that are accompanied by bleeding (hemophilia or bleeding disorder);
• with congestive heart failure (NYHA functional class II–IV), coronary artery disease, peripheral arterial disease or cerobrovascular disorders;
• with cerobrovascular diseases, patients who have had a stroke or who have episodes of transient ischemic attacks;
• with coronary artery disease, who have angina pectoris or who have suffered a myocardial infarction;
• for the treatment of perioperative pain during coronary artery bypass grafting (or when using a heart-lung machine);
• with severe liver or kidney failure;
• during breastfeeding;
• in the third trimester of pregnancy;
• under the age of 18.

Side effect

Gastrointestinal: the most commonly observed side effects are from the gastrointestinal tract. When taking nonsteroidal anti-inflammatory drugs (NSAIDs), peptic ulcers, perforated ulcers, or gastrointestinal bleeding may occur, sometimes leading to death, especially in older patients.

There have been reports of nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, abdominal pain, melena, hematemesis, ulcerative stomatitis, exacerbation of colitis or Crohn's disease after administration of NSAIDs. Gastritis was also observed with less frequency. Edema, hypertension and heart failure have been observed during treatment with NSAIDs.

Clinical trial and epidemiological data suggest that some NSAIDs (especially with long-term, high-dose treatment) may increase the risk of arterial thrombotic complications (eg, myocardial infarction or stroke).

Often (>1/100,

• dizziness
• nausea, dyspepsia, abdominal pain, diarrhea
• increased liver enzymes

Uncommon(>1/1000,

• vomiting, flatulence, constipation, oral ulceration, gastritis
• itching, exanthema, dermatitis, urticaria
• increased levels of urea and creatinine in the blood

Rarely (>1/10000,

• anemia
• anaphylactic reactions (including shock)
• visual impairment
• arterial hypertension (including complicated), heart failure
• dyspnea
• melena (including hemorrhagic diarrhea), ulcerations in the gastrointestinal tract, gastrointestinal bleeding
• swelling of the face.

Very rare/ isolated cases (

• granulocytopenia, thrombocytopenia, neutropenia, hemolytic anemia, hyperkalemia
• depression, unusual dreams, insomnia
• paresthesia, tremor, drowsiness, headache, dysgesia (taste perversion)
• vertigo, ringing in the ears
• cardiopalmus
• hot flashes, vasculitis
• bronchospasm
• hematemesis, gastric ulcer, pancreatitis
• hepatitis
• hemorrhagic rash, eczema, severe mucocutaneous reactions
• nephrotic syndrome, renal failure, interstitial nephritis
• increased fatigue, leg cramps
• increased alkaline phosphatase levels, weight gain

Overdose

There is no data on an overdose of aceclofenac in humans. Possible symptoms include headache, nausea, vomiting, stomach pain, dizziness, drowsiness, gastrointestinal irritation and bleeding, diarrhea, disorientation, agitation, coma, tinnitus, hypotension, respiratory distress, loss of consciousness, convulsions. In cases of severe poisoning, acute renal failure and liver damage may develop.

Treatment. Treatment of acute NSAID poisoning involves the use of antacids (if necessary) and other supportive symptomatic treatment for complications such as hypotension, renal failure, seizures, gastrointestinal irritation, and respiratory depression.

Treatment of acute poisoning when taking aceclofenac orally consists of preventing absorption of the drug by gastric lavage and the use of activated charcoal (repeated doses) as soon as possible after an overdose.

Forced diuresis, dialysis or hemoperfusion may not be effective enough to eliminate NSAIDs due to the high degree of protein binding of NSAIDs and extensive metabolism.

Drug combination

If you take the drug together with blood pressure medications and diuretics, the therapeutic effect of these medications may be weakened. If you have diabetes mellitus of the first degree, you should carefully monitor your blood sugar levels while taking the drug. Do not take simultaneously with aspirin, oral contraceptives, medications containing lithium and potassium, cyclosporins, blood thinners.

You should drive carefully while taking Aethral. Possible decrease in concentration.

Aertal price, where to buy

The price of Airtal tablets in Ukraine is about 200 UAH for 60 pieces of 100 ml. The same amount of medicine in Kharkov will cost 180 UAH.

The powder form of the drug will cost 100 UAH for 20 packages of 100 mg. At retail, Aertal sachets are sold at 4 UAH per piece.

https://www.youtube.com/watch?v=BwvFyrdEHUw

The average price for ointment in Ukraine is 52 UAH. You can buy the cream in Kharkov pharmacies for 60 UAH.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Aertal tab. p.p.o. 100 mg n60Almirall,SA/Gedeon Richter
• Aertal por. d/susp.internal 100 mg n20Industrias Pharmaceuticals Almiral S.A.
• Aertal tab. p.p.o. 100 mg n20Almirall,SA/Gedeon Richter

Pharmacy Dialogue

• Aertal cream tube 1.5% 60g
• Aertal (por.d/susp.100mg pack.3g No.20)
• Airtal (tablet p/o 100 mg No. 60)
• Airtal (tablet p/o 100 mg No. 20)

Europharm* 4% discount using promo code medside11

• Aertal cream 1.5% 60 JSC Gedeon Richter
• Aertal tablets 100 60 pcs. JSC Gedeon Richter
• Aertal powder for suspension 100 mg/3 g n20 sachetsIndustrias Farmaceuticas Almiral

show more

Pharmacy24

• Aertal 100 mg N60 tablets VAT”Gedeon Richter”, Ugorshchina
• Aertal 60 g cream VAT”Gedeon Richter”, Ugorshchina
• Aertal 100 mg No. 20 tablets VAT”Gedeon Richter”, Ugorshchina
• Aertal 100 mg No. 20 powder for oral suspension VAT “Gedeon Richter”/Industrias Pharmaceuticals Almiral, S.A., Ugorshchina/Spain

PaniPharmacy

• Aertal cream Aertal cream 15mg 60g Hungary, Gedeon Richter
• Aertal tablets Aertal tablets. 100 mg No. 20 Hungary, Gedeon Richter
• Aertal tablets Aertal tablets. 100 mg No. 60 Hungary, Gedeon Richter
• Aertal Aertal por. for oral susp. 100 mg pack. No. 20 Hungary, Gedeon Richter

show more

Compound

Aertal contains aceclofenac, a non-steroidal anti-inflammatory substance that has a pronounced analgesic and antipyretic effect. The following are added as additional components:

• titanium oxide;
• aspartame;
• methyloxypropylcellulose;
• sodium saccharinate.

The drug is produced in the form of biconvex tablets enclosed in a smooth shell. 1 tablet contains 100 mg of active substance. It includes:

• glyceryl distearate;
• croscarmellose sodium;
• polyvinylpyrrolidone;
• microcrystalline cellulose.

1 blister contains 10 tablets; a standard cardboard package contains from 2 to 9 blisters.

Airtal powder contains: 0.1 g of aceclofenac in one sachet, excipients (sorbitol, aspartame, titanium dioxide, hypromellose, flavorings).

Tablets: 0.1 g of active substance in one tablet, excipients (glycerol distearate, povidone, microcrystalline cellulose, hypromelose, E171, macrogol stearate).

Airtal ointment: 1.5 g of active substance per 100 g of ointment, excipients (liquid paraffin, water, methyl and propyl parahydroxybenzoate, emulsion wax).

Interaction with other drugs

The metabolism of aceclofenac occurs using cytochrome P450 2C9. Studies indicate that aceclofenac may inhibit this enzyme. Therefore, there is a potential for pharmacokinetic interactions with phenytoin, cimetidine, tolbutamide, phenylbutazone, amiodarone, miconazole and sulfafenazole.

As with other drugs in the NSAID group, there is a risk of pharmacokinetic interaction with other drugs eliminated by active renal secretion, such as methotrexate and lithium.

Aceclofenac, the active substance of the drug Airtal, is almost completely bound to albumin in plasma, so the likelihood of substitutive interactions with other drugs that are highly protein bound should be taken into account.

The following combinations should be avoided. NSAIDs inhibit the secretion of methotrexate by the renal tubules, and a mild metabolic interaction may occur, leading to decreased clearance of methotrexate. Therefore, NSAIDs should always be avoided during high-dose methotrexate therapy.

Some NSAIDs inhibit the clearance of lithium by the kidneys, resulting in increased serum lithium concentrations. If frequent monitoring of lithium levels is not possible, this combination should be avoided.

NSAIDs inhibit platelet aggregation and damage the gastrointestinal mucosa, which may increase the activity of anticoagulants and increase the risk of gastrointestinal bleeding in patients taking anticoagulants. If close monitoring is not possible, the use of aceclofenac in combination with oral anticoagulants of the coumarin group, ticlopidine, thrombolytics and heparin should be avoided.

The following combinations may require dose adjustment and caution when used. The potential for interaction between NSAIDs and methotrexate should also be taken into account when using low doses of methotrexate, especially in patients with impaired renal function.

If combination therapy is necessary, renal function should be monitored. Caution should be exercised when using methotrexate with NSAIDs within 24 hours as methotrexate concentrations may increase, which may result in increased drug toxicity.

It is believed that the use of NSAIDs in combination with cyclosporine or tacrolimus may lead to an increased risk of nephrotoxicity due to a decrease in the synthesis of prostacyclin in the kidneys. Therefore, monitoring of renal function is necessary during combination therapy.

Concomitant therapy with aspirin and nonsteroidal anti-inflammatory drugs may increase the incidence of side effects, so caution should be exercised with such combinations.

NSAIDs may reduce the diuretic effect of furosemide, bumetanide and the antihypertensive effect of thiazides. Concomitant use of potassium-sparing diuretics may lead to increased potassium concentrations; therefore, monitoring serum potassium levels is necessary.

NSAIDs may also reduce the effect of some antihypertensive medications. ACE inhibitors or angiotensin II receptor antagonists in combination with NSAIDs can lead to impaired renal function.

The risk of acute renal failure, which is usually reversible, increases in certain categories of patients with compromised renal function, for example, in the elderly or in patients with dehydration. Therefore, when using NSAIDs in this combination, caution should be exercised, patients should receive sufficient fluids, and monitoring of renal function is recommended.

Aceclofenac, when used simultaneously with bendrofluazide, did not lead to changes in blood pressure, but interactions of acecofenac with other antihypertensive drugs, for example, beta-blockers, cannot be excluded.

Other possible interactions. There are isolated reports on the hypoglycemic and hyperglycemic effects of NSAIDs. Therefore, when prescribing Airtal, the possibility of adjusting the dosage of drugs that can lead to hypoglycemia should be considered.

Contraindications

The drug can cause serious harm if the patient has diseases of the stomach or intestines, especially in acute form. These are erosions, ulcers, gastritis, colitis, bleeding from the gastrointestinal tract, UC, Crohn's disease, hepatitis, and other active liver pathologies. Diseases of the respiratory system also have contraindications to therapy with Aertal, these are:

• bronchospasm;
• bronchial obstruction;
• with great caution - bronchial AS src=»https://tyubik.net/uploads/posts/2018-10/1539787576_protivopokazanie-nalichie-bronhospazma.jpg» class=»aligncenter» width=»500″ height=»287″[/ img]

Allergic reactions to any NSAIDs are also common; they must be excluded before starting use (urticaria, rhinitis, spasms, angioedema). Due to its ability to thin the blood, Airtal can provoke bleeding, so it should not be taken after operations, especially on the heart, blood vessels, with decreased coagulation, diseases of the blood, or the hematopoietic system.

It is prohibited to be treated with the drug in case of renal failure or severe kidney disease.

Other contraindications are hyperkalemia, heart failure, ischemia, age under 18, lactation. Inhibition of prostaglandins can negatively affect the development of the fetus, and the drug should not be taken during pregnancy.