Espa-Lipon 600 tablets. Instructions for use, price, reviews

Espa-Lipon 600 is an effective drug, the main form of release of which is oblong tablets. This medication belongs to the pharmacological group of metabolic agents, the components of which have a direct effect on metabolic processes in the human body.

Espa-Lipon-600 tablets are characterized by high therapeutic effectiveness and an affordable price. In most cases, this drug is prescribed in combination with basic medications to improve the general condition of the body.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Thioctic acid is an antioxidant that is formed in the body during the decarboxylation of alpha-keto acids. It has an effect similar to B vitamins . Plays a role in energy metabolism, regulates lipid (cholesterol metabolism) and carbohydrate metabolism. It has a lipotropic and detoxifying effect . The effect on carbohydrate metabolism causes an increase in glycogen in the liver and a decrease in glucose in the blood.

It improves the trophism of neurons, as it accumulates in them and reduces the content of free radicals and liver function (with a course of treatment).

It has hypolipidemic , hypoglycemic , hepatoprotective and hypocholesterolemic effects .

Pharmacokinetics

Thioctic acid is absorbed from the intestines. Cmax is reached on average after 55 minutes. Bioavailability—30%. In the liver it is oxidized and conjugated, resulting in the formation of metabolites. 80-90% of inactive metabolites are excreted by the kidneys. T1/2 - 20-60 min.

Pharmacological properties

Espa-Lipon 600 are tablets (the price of this drug is affordable for most middle-income consumers) that have the following pharmacological properties:

• act as an artificial antioxidant that promotes rejuvenation of all tissues, including internal organs;
• bind free radicals that entered the body from the environment, or were formed during the breakdown of food, alcoholic beverages, and metabolic processes in the liver;
• perform the function of a synthetic coenzyme, which is directly involved in the process of transformation of biochemical substances that have an antitoxic effect;
• heal the tissues of the liver, pancreas, and gastrointestinal tract;
• remove from the body protein fragments of foreign biological agents that have entered the blood from the environment (viruses, bacteria, fungi);
• protect cells of internal organs from the pathogenic effects of reactive radicals, which can lead to tissue destruction and a decrease in their functional activity;
• reduce the concentration of glucose in the blood serum, which has a beneficial effect on the well-being of patients with diabetes of all types;
• improve intracellular nutrition of cells, and also takes part in mitochondrial metabolism;
• help reduce the level of pyruvic acid (this property of the drug is realized only in patients with diabetes).

The pharmacological properties of this medication are realized only if it is taken in a course course over a continuous period of time. Espa-Lipon 600 is not designed for symptomatic therapy.

Clinical studies of this drug have confirmed its effectiveness in patients who have suffered poisoning with heavy metal salts. The active substance of Espa-Lipon 600 tablets accelerates the process of removing these chemical compounds from the patient’s body.

Espa-Lipon, instructions for use (Method and dosage)

Treatment is often started with intravenous infusions followed by a transition to Espa-Lipon tablets. The tablets are taken orally, without chewing, 30 minutes before meals, once a day. Daily dose 600 mg. Course 3 months If prescribed by a doctor, the drug can be taken for a longer period of time.

In diabetes mellitus, blood glucose control is necessary During treatment, alcohol , which weakens the effect of the drug.

special instructions

In this section we will look at some important points.

Driving

It is worth considering that while driving you may suddenly develop a headache and feel sick. Additionally, you may also faint. This is why many doctors recommend avoiding long trips and staying at home if possible.

Pregnancy

During pregnancy, taking the drug Espa-Lipona is highly undesirable. This is due to the fact that the active substance causes irreparable harm to the health of the fetus, up to the development of conditions such as:

• Frozen pregnancy;
• Development of serious pathologies in the fetus;
• Spontaneous miscarriage.

In addition, the girl herself also has a negative impact. She may experience severe pain in the abdomen, heart, back, vomiting, nausea, dizziness, and general ailments.

It is also not recommended to take this drug while breastfeeding your baby.

Childhood

This drug should not be taken by children under 18 years of age.

With impaired kidney function

In case of severe damage to the kidneys, it is not recommended to take this drug.

With impaired liver function

This drug is intended to treat liver disease.

Release from pharmacy

Espa-Lipon will be given to you only if you show a prescription from your doctor.

Interaction

An enhanced hypoglycemic effect is observed when used with insulin or oral hypoglycemic drugs.

Reduced effectiveness of Cisplatin when prescribed with thioctic acid .

Ethanol weakens the effect of the drug.

Strengthens the anti-inflammatory effect of GCS .

Binds metals, so iron supplements cannot be prescribed at the same time. The administration of these drugs is spread over time (2 hours).

Side effects

According to reviews, Espa-Lipon is generally well tolerated by patients, however, there are isolated cases of a number of side effects such as:

• nausea, vomiting, headache, difficulty breathing;
• increased sweating, cramps;
• allergic reactions such as eczema, urticaria, hemorrhagic rash and anaphylactic shock.

In patients with peripheral polyneuropathy, at the beginning of therapy, a sensation of “pins and needles” may appear on the skin. Rapid intravenous administration of the drug can cause blurred vision, pinpoint hemorrhages in the mucous membranes and skin, and increased intracranial pressure.

Analogs

Level 4 ATX code matches: Verona
Phibs

Gastrikumel

Fitogastrol

Thyroidea Compositum

Berlition

Thiolepta

Gastric collection

Brewer's yeast

Lipoic acid

Rosehip syrup

Omez DSR

Octolipen

Thioctacid

Thiogamma

Figurin

Berlition , Octolipen , Lipamide , Thiogamma , Thioctacid .

Features of lipid metabolism

Our body is a complex system in which everything must work harmoniously and in full interaction with each other. If one mechanism is violated, then a whole chain of reactions is triggered, so the first negative violations must be dealt with immediately.

Lipids are hydrophobic substances that are necessary for various physiological reactions, as well as for providing energy to the body. Their operating principle may differ from each other, since not all of them have the same structure.

Classification of lipids:

1. Phospholipids are responsible for many metabolic processes in the liver and improve brain function;
2. Triglycerides are deposited in the subcutaneous fat layer and are a source of energy;
3. Steroids (cholesterol) are necessary to seal cell membranes and regulate the functioning of the endocrine glands.

Together, these compounds form a number of chemicals that are needed to maintain proper metabolism, the functioning of the hormonal system, as well as proper heat exchange. Lipids are involved in physiological processes associated with the construction of proteins, hormones, and also support the reproductive function of the body.

Without some of them, full absorption of fat-soluble vitamins is impossible. As you know, everything should be within normal limits, but if lipids (fats) enter the body in excess, then various kinds of disorders may occur.

Possible manifestations of fat metabolism disorders:

• Deterioration of intestinal and liver function;
• Hormonal imbalances;
• Atherosclerotic vascular damage;
• Excess body weight;
• Deterioration of skin turgor;
• Decreased memory;
• Improper functioning of the immune system;
• Obesity of internal organs;
• Increased fatigue and weakness.

The greatest negative impact affects the functioning of the cardiovascular and hormonal systems. This is due to the accumulation of “bad” cholesterol in the blood, which belongs to low-density lipoproteins. To minimize its impact, various medications are prescribed, as well as a low-fat diet.

Reviews about Espa Lipona

There are not many reviews about the use of this drug, because Espa-Lipon was rarely used as monotherapy. Most often there are reviews about its use in diabetic polyneuropathy . Patients note that long-term use helped get rid of pain in the legs and feet, burning, “pins and needles”, muscle cramps and restore lost sensitivity.

In case of fatty liver in diabetes mellitus, the drug promoted normal bile secretion and eliminated dyspeptic symptoms. The improvement in the patients' condition was confirmed by tests (normalization of transaminase ) and positive dynamics of ultrasound signs.

There is information when Espa-Lipon was successfully used in complex therapy of atherosclerosis .

In all cases, treatment began with drip administration (10-20 droppers) in a hospital setting, and then patients took tablet form, sometimes the daily dose was 1800 mg (3 tablets).

Side effects include nausea and heartburn when taking tablets and thrombophlebitis when administered intravenously.

Contraindications

Espa-Lipon is not prescribed to patients suffering from chronic alcohol dependence, glucose-galactose malabsorption syndrome, as well as to persons with lactase deficiency in the body.

Taking Espa-Lipon with caution is recommended for patients with diabetes mellitus - with mandatory adjustment of the dose of hypoglycemic agents. Children under 18 years of age should not be treated with Espa-Lipon due to the lack of data on the safety of the drug for this category of patients. If there are important indications, the drug can be taken by persons of this age group strictly according to the doctor’s recommendation, taking into account the individual dosage.

The complete safety of Espa-Lipon for the health of the fetus when taking the drug during pregnancy has also not been proven. If it is necessary to treat a woman with Espa-Lipon during lactation, it is necessary to decide on the issue of temporarily weaning the baby from the breast.

Espa-Lipona price, where to buy

You can buy the drug in pharmacies in Moscow and other Russian cities. Cost of Espa-Lipon 600 No. 30 from 697 rub. up to 723 rub.

• Online pharmacies in UkraineUkraine

Pharmacy24

• Espa-lipon 600 mg No. 30 tablets Pharma Wernigerode GmbH, Nimechchina
  358 UAH.order
• Espa-lipon 300 mg 12 ml No. 10 solution for injection Hamelin Pharmaceuticals GmbH, Nimecchina

  508 UAH order

• Espa-lipon 600 mg 24 ml No. 5 solution for injection Hameln Pharmaceuticals GmbH, Nimecchina

  441 UAH order

Release forms and composition of the drug

Espa-Lipon 600 is a metabolic agent that is produced by a German pharmaceutical company located in Hamburg. This medication is available in the form of rich yellow tablets with a dividing strip in the center, which are covered with a protective film.

The drug is packaged in cell blisters, which are made of plastic and sunscreen foil, and are also designed for 10 tablets each. 1 pack of metabolic agent may contain 3, 6 or 10 blisters, depending on the configuration.

The main packaging of the medication is a cardboard box, inside of which there are detailed instructions for using Espa-Lipon 600 tablets. The price of this drug corresponds to its quality characteristics.

The metabolic agent Espa-Lipon 600 is also available in the form of a liquid and clear solution for intravenous administration by drip infusion. The medication is filled into glass bottles. Espa-Lipon 600 tablets contain only one active substance, which is thioctic (alpha-lipoic) acid.

Espa-Lipon is produced in the form of tablets and ampoules

The mass concentration of this component is 600 mg in 1 tablet. The presence of this chemical compound ensures the implementation of the pharmacological properties of the drug. The table below lists the components of this medication that perform an auxiliary function.

The constituent chemical compounds of the metabolic agent Espa-Lipon 600 are completely safe for the human body. The main and auxiliary components of this drug do not lead to a decrease in the functional activity of internal organs, activate metabolic processes and improve overall well-being.

The composition of this medication has a beneficial effect on the health of men and women suffering from diseases associated with metabolic disorders.

Indications for use

Thioctic acid is a metabolic agent, so its range of applications is quite wide. As part of complex therapy, it is indicated for lipid metabolism disorders, since it has a lipotropic effect and prevents fatty degeneration of the liver. This property of the drug is indicated for viral hepatitis and liver fibrosis.

Espa-Lipon is indicated for:

• Alcoholic cirrhosis of the liver;
• Pancreatitis;
• Atherosclerosis of blood vessels;

• Viral hepatitis;
• Heart failure;
• Cholecystitis;
• Hepatic encephalopathy;
• Poisoning with heavy metal compounds and mushrooms;
• Diabetic polyneuropathy.

Hyperglycemia caused by diabetes mellitus leads to the development of intense glycosylation in the blood vessels. This leads to a constant decrease in endoneurial blood flow, which is accompanied by hypoxia. This condition is caused by an excess of free radical ions and toxins that damage cells and neurons.

In 1995, an extensive multicenter study was conducted regarding the effectiveness of thioctic acid in diabetic ponyneuropathy. Patients who took the drug for a long time experienced a decrease in symptoms such as numbness of the limbs, burning sensation and paresthesia.

Pharmacokinetics

After oral administration, the medication is quickly absorbed in the small intestine and enters the bloodstream. It should be drunk separately from the main meal so as not to reduce the therapeutic effect of the drug, since the quality of absorption decreases.

Metabolism of thioctic acid occurs in the liver parenchyma. The half-life of Espa-Lipon averages 30 minutes. Metabolites are excreted primarily by the kidneys. The bioavailability of thioctic acid compounds is high.

The drug has such a quality as a “first round pass” through the liver cycles. This characteristic property is due to the fact that the drug loses some of its properties under the influence of clearance. If hepatic blood flow is impaired, this function may slow down.