Canesten - description of the drug, instructions for use, reviews

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Manufacturers: Kern Pharma SL

Active ingredients

• Clotrimazole

Disease class

• Not indicated. See instructions

Clinical and pharmacological group

• Not indicated. See instructions

Pharmacological action

• Broad spectrum antifungal

Pharmacological group

• Antifungal agents
• Other synthetic antibacterial agents

general characteristics

Consists of main and additional substances.
The active compound is clotrimazole. 1 tablet contains 100 mg of this medicine. The mechanism of action is based on reducing the development of fungal microflora. It reduces the production of the main cell wall substance ergosterol. For this reason, there is no further development of fungi in the vagina. It acts only on vegetative forms. That is, the impact on disputes is very limited. That is why there are special treatment regimens for this medicine. After contact with the mucous membranes, the substance is absorbed into the systemic bloodstream. Only a quarter of the drug enters the blood. The rest acts locally. The medicine will travel through the blood to the liver. There it is neutralized. It is released by the kidneys after a day.

Indications

Canesten ointment is an ointment preparation that is intended for the treatment of fungal diseases of the skin and mucous membranes. This product neutralizes pathogenic microorganisms and helps cleanse the affected areas of the skin from the pathogen. The drug has a wide spectrum of action, thanks to which it neutralizes various types of fungus, yeast and mold microorganisms.

Kanesten ointment is used to treat the following diseases:

• Fungal diseases of the skin and mucous membranes;
• Damage to the epidermis by yeasts and molds;
• Skin diseases caused by other microorganisms that are sensitive to clotrimazole;
• Mycoses affecting the skin of the feet and hands, as well as the epidermis of the folds of the skin and torso;
• Pityriasis versicolor and erythrasma.

The drug in the form of a vaginal cream can be used to treat candidiasis vulvitis, balanitis, as well as for the purpose of sanitizing the birth canal before childbirth.

It is prohibited to use Canesten ointment in the following cases:

• Individual sensitivity to the components present in the composition;
• First trimester of pregnancy.

Simultaneous use of ointment with drugs containing nastatin and natamycin may reduce the effectiveness of the drug.

Indications for use

Indications for the use of Canesten depend on the dosage form of the drug. Canesten cream is used in therapy:

• dermatomycosis of the skin;
• versicolor;
• candidal vulvitis;
• candidal balanitis.

The cream is used in the treatment of any mycoses caused by pathogenic and opportunistic microflora sensitive to the action of clotrimazole.

The spray is used to treat ringworm, fungal infections of the mucous membranes, and lichen versicolor.

Canesten vaginal tablets are prescribed for the treatment of candidal vaginitis, as well as superinfections caused by fungi and bacteria that are sensitive to the action of clotrimazole.

Compound

Using the ointment will help cope with the symptoms of the disease thanks to the active antifungal effect of the main component.

The effectiveness of Canesten ointment is achieved due to the content of clotrimazole in the composition of the drug. This substance is present in many topical medications. It has an excellent antifungal effect against various types of fungi and other microorganisms.

The action of clotrimazole is aimed at preventing the spread of the disease, which provides a fungistatic effect. In addition, this substance destroys the main components of the fungal membrane, which are necessary for their existence and reproduction. In this case, the fungal cells die and the disease gradually passes.

Also, the drug Canesten contains a complex of additional substances, which forms the necessary structure and consistency of the ointment. Thanks to the additional components, the ointment spreads well and is absorbed into the skin.

Sources

• https://ngribok.ru/preparaty/mazi-i-kremy/kanesten.html
• https://lekhar.ru/lekarstva/protivogribkovye-preparaty/kanesten-instrukcija-po-primeneniju/
• https://DoloyGribok.ru/preparaty/kanesten.html
• https://akandidoz.ru/preparaty/kanesten-svechi-instrukciya.html
• https://mazikrem.ru/kanesten/
• https://mazimed.ru/maz-kanesten/

Candles

Canesten suppositories are used to treat thrush in women. They are produced in the form of an oblong shape of a yellowish color. The active substance clotrimazole has a detrimental effect on fungi of the genus Candida. The peculiarity is the absence of inhibition of the growth of its microflora. This means that after treatment with these suppositories there is no need to use various biotic substances to normalize the vaginal microflora.

It is recommended to use candles once a day for a week. It is advisable to carry out treatment before bedtime. This will ensure the formation of the desired effect on the fungal flora. Candles should be used in accordance with the recommendations:

• the suppository must be inserted in a lying position;
• the candle should be inserted as far as possible;
• this ensures maximum absorption of the substance from the vaginal mucosa;
• After administration, you should lie down for 10-15 minutes so that the candle does not leak back.

Suppositories are often used as complex therapy. The price of Canesten candles is within 300 rubles. One package is enough for the entire course of treatment. There are several types depending on the amount of the main substance. The maximum concentration is 500 mg. Only 1 suppository is available in this dose. It is intended for loading dose. It is used for severe vaginal candidiasis.

The 100 mg release contains 6 suppositories. The course of treatment in this case is 6 days. The treatment regimen is chosen by the doctor.

Cost and analogues

Clotrimazole is a cheaper analogue of the drug

Canesten cannot boast of an affordable price. One vaginal tablet at a dosage of 500 mg costs about 400 rubles. A package of six tablets will cost approximately 500 rubles. The cost of the spray and cream is about 400 rubles. The drug is available without a prescription, but is rarely found in pharmacies.

If the drug is not available in pharmacies, you can use Canesten analogues; finding them will not be difficult. The list of substitutes and analogues of the drug Canesten is given in the table indicating the average cost and volume of packaging.

pharmachologic effect

Antifungal drug. Clotrimazole, the active substance of Canesten spray, is an imidazole derivative and has a wide spectrum of antimycotic action. The mechanism of action of clotrimazole is associated with inhibition of ergosterol synthesis, which leads to disruption of the structure and functions of the cytoplasmic membrane of fungi. It has fungistatic or fungicidal activity depending on the concentration at the site of infection.

Canesten is active against dermatophytes, yeast-like, mold fungi, as well as pathogens of pityriasis versicolor (Pityriasis vers.) and erythrasma. Along with antimycotic, Canesten has an antimicrobial effect against Trichomonas vaginalis, gram-positive (streptococci, staphylococci) and gram-negative microorganisms (Bacteroides, Gardnerella vaginalis).

In vitro, at concentrations of 0.5-10 μg/ml, clotrimazole inhibits the reproduction of bacteria of the Corynebacteria family of gram-positive cocci (except for enterococci) and has a trichomonacid effect at a concentration of 100 μg/ml.

Primary resistant strains of clotrimazole-sensitive fungi are very rare; the development of secondary resistance is observed only in isolated cases and only under certain therapeutic conditions.

Indications and contraindications

What is treated with canesten

The list of indications for canesten is quite long. But under no circumstances self-medicate; consult a good specialist who will determine what type of microorganism is causing the infection and make the right prescription. Of course, the fact that the drug is practically not absorbed into the blood makes it safe, it is sold from pharmacies without a prescription, but do not neglect basic safety rules, do not self-medicate. Canesten is used to treat:

• vaginal candidiasis or thrush;
• pityriasis versicolor;
• stomatitis;
• candidiasis of the glans penis - balanitis;
• bacterial or fungal vulvitis;
• disease of large skin folds - erythrasma;
• other diseases caused by fungal infection, gram-positive or gram-negative bacteria.

It is used to sanitize the birth canal before natural birth and after cesarean.

When not to use Canesten

As official statistics show, there are practically no contraindications for external use. But the drug cannot be used if:

there is an intolerance to one of the components; it should be used with caution in case of liver failure and people with cardiovascular diseases; in the first trimester of pregnancy.

In subsequent trimesters, use is possible, but only if the doctor decides that the possible risk for the mother and child does not outweigh the benefits.

During clinical trials, side effects were identified that occur in a small percentage of patients:

• burning, redness, tingling in the area where the cream was applied;
• very rarely headache, indigestion, stomach pain.

Canesten contains substances that destroy latex, which will reduce the protective function of the condom.

Similar drugs:

• Natamycin Substance-powder
• Irunin Capsule
• Lamisil Oral tablets
• Primafungin Vaginal suppositories
• Candibene Vaginal tablets
• Mycozoral Ointment for external use
• Lotriderm Cream
• Jenamazol 100 Vaginal tablets
• Rumycoz Capsule
• Mycozoral Oral tablets

** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Canesten, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Canesten is provided for informational purposes only and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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pharmachologic effect

Canesten is an antifungal topical cream containing clotrimazole. The drug Canesten is characterized by a wide spectrum of action, its activity is expressed against mold and yeast fungi (including Prodoturola and Cladospporium spp., Asppergillus spp., Torulopsis and Madurella spp., Criptococcus neoformans, as well as Candida spp.), dermatophytes (including Microspporum spp., Epidermophyton floccosum, Trichophyton spp.). Dimorphic fungi (Histoplasma capsulatum, Coccidiodes immitis, Blastomyces dermatitidis) and Nokardia actinomycetes are also sensitive to the drug.

Clotrimazole, which is the active component of Canesten cream, belongs to the group of imidazole derivatives and has a fungicidal and fungistatic effect characteristic of this group. For example, clotrimazole inhibits the production of ergosterol, nucleic acids and proteins in the cells of sensitive microorganisms, which first leads to disruption of reproduction and development, and then to disruption of membrane integrity and death of fungi.

The minimum concentrations of clotrimazole that have a pronounced antifungal effect during the studies were up to 8 mg/l. Canesten, creating a level of at least 10-20 mg/l, exhibits a fungicidal effect against fungi of the genus Candida and dermatophytes.

Strains that are resistant to Canesten are rare. In addition to antifungal activity, clotrimazole also leads to the death of some gram-positive cocci (at a level of 0.5-10 mg/l - Staphylococcus spp.), trichomonas (Trichomonas vaginalis at a level of 100 mg/l) and corynebacterium (Corynebacterium minutissimus at a level of 0.5- 10 mg/l).

In studies of 1% Canesten cream with labeled clotrimazole, resorption of 3-10% of the total dosage was observed. Plasma levels of unchanged clotrimazole were below the detection limit (10 μg/mL). Such data indicate that systemic exposure to Canesten cream is negligible.

Operating principle

Canesten simultaneously has fungistatic and fungicidal (high concentrations) effects. In simple terms, it not only blocks the growth of fungi, but also their reproduction and causes cell death. Clotrimazole attaches to the outer cell membrane of a bacterium or fungus and blocks the synthesis of ergosterol. This is a building material for the shell, without it it cannot be renewed. Gradually, substances accumulate inside the cell that cause its death.

In high concentrations, which accumulate with constant use of the drug, it penetrates inside and destroys the membranes of intracellular elements (mitochondria). Releases hydrogen peroxide, which also destroys microorganisms from the inside.

Clotrimazole is active against dermatophytes, dimorphic fungi, actinomycetes, and against several types of molds and yeasts. It is worth noting that strains that it does not affect are quite rare. When applied topically, less than 5% of the active substance enters the bloodstream; this is an absolutely safe amount.

Composition: main and additional substances

All dosage forms contain one active ingredient - clotrimazole. In addition to this, the following components are added to the cream:

• a solvent with a pleasant, unobtrusive odor, benzyl alcohol, which disinfects the ingredients of the cream;
• cetyl stearyl alcohol, which softens the skin and maintains a uniform consistency of the cream;
• cetyl palmitate - disinfects, softens the skin, has an anti-inflammatory effect;
• emulsifier sorbitan stearate, helps mix the components into a homogeneous mass;
• synthetic stabilizer and emulsifier polysorbate 60;
• fatty alcohol 2-octyldodecanol, which lubricates and softens the skin and prevents the cream from separating.

A mixture of these components is dissolved in distilled water. Tablets, spray and solution contain, in addition to clotrimazole, silicon dioxide, calcium lactate, magnesium stearate, lactic acid, macrogol 400, etc.

Additional substances help preserve the medicine, are harmless to health, and do not react with the active ingredient.

Cream analogues

Canesten has a therapeutic effect due to the content of 1% clotrimazole. You can choose an analogue in two ways:

1. buy a medicine with the same main substance, in the same concentration;
2. replace canesten with an antifungal drug that acts on the same microorganisms.

There are many drugs that contain clotrimazole: Bifosin (Russia), Clotrimazole (Romania), Kanison (India), Candide (India) and others. Price ranges from 50 to 250 rubles, there are different dosage forms.

If you select an analogue based on the spectrum of activity (the list of microorganisms that die under the influence of the drug), then you can use our review of ointments or ask your doctor for advice.

When replacing a prescribed medication, it must be taken into account that drugs acting on the same substance, in the same dosage, may have different degrees of purification and composition of excipients

This may lead to an individual reaction to the analogue. Important! The doctor should choose an analogue of the drug; he knows how to determine the spectrum of action of the drug, in which cases you can choose a drug from one pharmacological group, and in which only with the same active substance. Nystatin and natamycin belong to the same group of antifungal agents and have a similar spectrum of action. But fungi may develop resistance to nystatin, but natamycin will be effective in the same patient

Features of the use of Canesten candles

Do not take vaginal tablets orally.

Since the fungus affects not only the internal but also the external genital organs, a combination of treatment of all areas should be used.

Treatment of the sexual partner is also recommended.

During pregnancy and lactation

Few clinical studies have been conducted, so it is recommended to avoid treatment with the pills during pregnancy. During breastfeeding, medication can be taken provided that feeding is suspended.

Taking during menstruation

The use of suppositories during menstruation is not recommended, because... undissolved medicine will flow out along with the secretions. It is necessary to complete treatment before the start of menstruation.

Is it possible to have sex during therapy?

It is advisable to suspend sexual activity for the period of treatment, because... infections can be transmitted through sexual contact. Tablets can reduce the effect of contraceptives.

special instructions

Both partners should be treated for genital infections, even if the other has no symptoms of the disease. It should be borne in mind that clotrimazole reduces the effectiveness of latex contraceptives (diaphragms and condoms), therefore, while using the drug, it is necessary to abstain from sexual activity to prevent reinfection.

For trichomoniasis, Canesten is recommended to be used in combination with a systemic antifungal drug (usually metronidazole is prescribed in the form of oral tablets).

During treatment, women should not use tampons or other drugs for intravaginal use, or douching.

During pregnancy, it is recommended to administer the tablets without using an applicator.

When using external forms of Canesten, avoid contact with the eyes. Do not apply to areas of the skin where the integrity of the skin is damaged. Do not use sealed dressings.

If there is no clinical improvement within 4 weeks when treating skin infections, microbiological testing should be performed to confirm the diagnosis and exclude another cause of the disease.

Women undergoing treatment with Canesten vaginal tablets should consult a doctor if:

• Improvement does not occur within 7 days after starting therapy;
• Treatment is accompanied by increased body temperature, nausea, pain in the back and lower abdomen, vaginal bleeding, purulent vaginal discharge with an unpleasant odor;
• Symptoms of the disease reappear within 2 months.

Advantages and disadvantages

Advantages of the drug

Using canesten has more advantages than disadvantages:

• active against a wide range of microorganisms;
• local dosage forms practically do not enter the blood, which makes systematic use safe;
• a large selection of analogues with different prices;
• has virtually no contraindications.

Cons of Canesten

The disadvantages include:

• high cost of the original drug;
• the presence of substances that destroy latex.

Clotrimazole, which became the active component of canesten, is one of the first synthesized antimycotic drugs. Its action and side effects have been studied for more than half a century. When prescribing Canesten, the doctor is confident in the effect of the medicine on the infection and the body as a whole.

Video advertisement of a medicinal product (German):

Precautionary measures

You should be careful when using the drug, adhering to the following rules:

• Treat both sexual partners simultaneously
• Avoid contact of the cream with the mucous membranes of the eyes.
• Do not use the product vaginally during menstruation
• Patients with liver pathologies should have their function checked during treatment with the drug.
• When used externally, do not apply bandages.
• If signs of allergy appear, treatment with the drug is stopped
• If there is no effect for a month, the diagnosis should be checked.

When treating onychomycosis, the nail plates are cut short, and their surface should be rough for better penetration of the active substances.

Features of the use of vaginal tablets

When using vaginal tablets, precautions should be taken:

• do not use during menstruation;
• refuse intimacy for the duration of treatment;
• if the infection spreads to the labia, use additional cream;
• Use intravaginally only, avoid ingestion or contact with eyes;
• Do not use simultaneously with tampons, douching or spermicides.

Simultaneously with the treatment of the woman, it is necessary to treat her sexual partner. To do this, you can use Canesten cream.

Range of applications

Canesten is a strong antifungal drug based on clotrimazole, which, in turn, is an imidazole derivative. This substance has a wide spectrum of action on various types of fungal formations. Due to the effectiveness and relative safety of clotrimazole, drugs based on it are widely used in modern practice. This high popularity is due to the positive impact in the presence of the following categories of fungal formations:

• moldy;
• dermatophytes;
• yeast;
• actinomycetes.

These types of fungal infections are the causes of the formation of most ailments of the corresponding nature. At the same time, the positive dynamics of Canesten in relation to such infections determines its fairly widespread use. Based on this, we can highlight a list of diseases that can be treated with this remedy:

• pityriasis versicolor;
• candidal lesions;
• dermatophytosis;
• erythrasmas;
• vulvitis;
• balanitis;
• vaginitis

This list of diseases allows you to understand how effective Canesten and its analogs produced on the basis of clotrimazole are. The effectiveness of this product speaks for itself. Using the drug as part of complex therapy can give positive results in the shortest possible time. At the same time, clotrimazole-containing drugs, and in particular Canesten, show the best results in the treatment of thrush.

Instructions for use

Canesten cream is a product for external use. For adults, dermatologists advise applying the cream to infected areas three times a day. The solution is used up to 4 times a day.

The drug has a long shelf life of 3 years. But after this period it is better not to use the cream. Store at room temperature in a dark place - in a medicine cabinet.

Mode of application

To treat vulvitis, a small amount of cream is inserted into the vagina three times a day. The tablet form for vaginal administration is used depending on the amount of active substance and is taken a different number of times. The higher the dosage, the fewer injections are required.

To treat cutaneous mycosis, the drug is applied in a thin layer to the affected area in the morning, afternoon and evening until complete recovery.

Application for nail fungus

Before using medicinal cream against fungus on toenails, feet should be washed well with soap and dried. Apply a thin layer to the nail and nearby soft tissues three times a day for 2-3 months.

After complete recovery, it is recommended to use Canesten for several more weeks to consolidate the results.

Dosage

A small amount of cream should be spread over a palm-sized area and gradually rubbed in using massage movements. The solution is taken in a dosage of 10-20 drops per application.

Vaginal tablets are administered before bedtime according to the following scheme:

1. Single administration – 500 mg.
2. For 3 days – 200 mg.
3. For one week – 100 mg.

Overdose

Since the drug penetrates shallowly into the inner layers of the mucous membranes and skin, signs of an overdose are unlikely to appear. In case of accidental use of a tablet, suppository, or cream internally, it is necessary to carry out preventive gastric lavage. Especially if characteristic symptoms appear within an hour after taking it: nausea, dizziness, vomiting.

The active substance of Canesten, Clotrimazole, can reduce the effectiveness of antifungal drugs used in parallel, as well as the antibiotics nystatin and natamycin. Therefore, the method of treatment is chosen in advance, and the means are not combined.

Contraindications and restrictions for use

The drug Canesten, according to the instructions for use, cannot be used in case of individual intolerance to the main active ingredient and auxiliary components of the composition.

The cream is not intended to treat nail and scalp fungus. The spray can be used for this purpose, but such treatment is ineffective due to the characteristics of the active substance.

The drug can be used during pregnancy. You should refrain from using vaginal tablets only in the first trimester. No dosage form of the drug should be used during lactation. If treatment is necessary during this period, breastfeeding should be discontinued.

The drug should not be used to treat children under 12 years of age. Vaginal tablets are intended for adult women only.

Spray and cream should not be applied to the mammary glands during lactation, as this may provoke a hypersensitivity reaction.

Side effects

Intravaginal use of the drug is fraught with the occurrence of allergic reactions, which are expressed in noticeable weakness, shortness of breath and urticaria. The following symptoms may appear in the vagina and external genitalia:

• Burning
• Discharge
• Swelling
• Hyperemia
• Discomfort
• Itching.

When applying the drug Canesten to the skin and mucous membranes, the following side effects are noted:

• Swelling
• Peeling skin
• Skin rashes
• Blisters.

Rarely, the patient may experience abdominal pain. Frequent urination, gastralgia, signs of cystitis, pain during sexual intercourse, as well as pain in the partner’s genitals are noted.

Side effects

In general, the drug is well tolerated. In rare cases, allergic reactions have occurred.

When used intravaginally, the following are possible:

• From the reproductive system: burning, discomfort, itching, swelling and hyperemia of the vagina and external genitalia, vaginal discharge, burning sensation in the partner’s penis, pain during sexual intercourse;
• From the urinary system: frequent urination and intercurrent cystitis.

When used externally, sometimes a burning and tingling sensation occurs, blisters and redness appear at the site of application.

When Canesten is used in high doses, no serious reactions or life-threatening conditions occur. If the drug is accidentally taken orally, nausea and vomiting, impaired liver function, gastralgia, anorexia, and in rare cases also pollakiuria, hallucinations, drowsiness and allergic skin reactions are possible. Treatment involves taking activated carbon and carrying out symptomatic therapy.

Instructions for use

Dosage form

Vaginal cream, cream for external use, ointment for external use, powder for external use, solution for external use, vaginal tablets

pharmachologic effect

An antifungal agent from the group of imidazole derivatives for external and local (intravaginal) use, it reduces the synthesis of ergosterol, which is an integral part of the cell membrane of the microbial wall, and leads to a change in its structure and properties.

In small concentrations it has a fungistatic effect, and in large concentrations it has a fungicidal effect, and not only on proliferating cells. At fungicidal concentrations, it interacts with mitochondrial and peroxidase enzymes, resulting in an increase in the concentration of hydrogen peroxide to a toxic level, which also contributes to the destruction of fungal cells.

Active against pathogenic dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis), yeast and mold fungi (genus Candida, Torulopsis glabrata, genus Rhodotorula, Malassezia furfur), pathogens of pityriasis versicolor, erythrasma, gram-positive (Staphylococcus, Streptococcus, Corynebacter ium minutissimum) and gram-negative bacteria (Bacteroides, Gardnerella vaginalis), Trichomonas vaginalis.

Indications

Fungal infections of the skin and mucous membranes: dermatomycosis, dermatophytosis, trichophytosis, epidermophytosis, microsporia, candidiasis, stomatitis, interdigital fungal erosion, fungal paronychia; mycoses complicated by secondary pyoderma; candidiasis vulvitis, vulvovaginitis, balanitis, trichomoniasis; pityriasis versicolor, pityriasis versicolor, erythrasma; sanitation of the birth canal before childbirth.

Contraindications

Hypersensitivity, menstrual period (for vaginal forms), pregnancy (1st trimester). With caution. Lactation period.

Side effects

Local reactions: burning, swelling, irritation and peeling of the skin, paresthesia, erythematous rashes, blistering.

Allergic reactions (itching, urticaria).

With intravaginal administration - itching, burning, hyperemia and swelling of the mucous membrane; vaginal discharge, headache, gastralgia, frequent urination, intercurrent cystitis, burning sensation in the penis of the sexual partner, pain during sexual intercourse.

Application and dosage

Externally

Cream, ointment, lotion or solution is applied in a thin layer to the affected areas of the skin and mucous membranes 2-3 times a day (3-4 for a solution) and rubbed in gently

A single dose for a palm-sized surface area is a column of cream 5 mm long or 10-20 drops of solution.

The average course of treatment is about 4 weeks; upon completion (if clinical manifestations disappear), it is advisable to continue treatment for another 14 days.

The duration of therapy for erythrasma is 2-4 weeks, for lichen versicolor - 1-3 weeks.

Before lubricating the feet, wash them with warm water and soap and dry them thoroughly, especially between the toes. For fungal infections of the skin of the legs, after achieving a therapeutic effect, it is recommended to continue treatment for 2-3 weeks.

Vaginal cream or gel is administered in portions of 5 g deep into the vagina once a day for 3 days. For candidal vulvitis or balanitis, use 2-3 times a day for 1-2 weeks. Vaginal tablets are inserted deep into the vagina: 500 mg once, or 200 mg for 3 days, or 100 mg for 6-7 days (once a day, in the evening). The course of treatment is usually combined with treatment of the external genitalia with a cream, ointment or solution. If necessary, the course of treatment can be repeated. For sanitization of the birth canal, a single administration of one tablet is recommended. For urethritis, a 1% solution is instilled into the urethra for 6 days.

special instructions

To prevent reinfection, simultaneous treatment of sexual partners is necessary. In the second and third trimesters of pregnancy, the use of a vaginal applicator is undesirable. For trichomoniasis, it is recommended to combine treatment with chemotherapy drugs (metronidazole orally).

After applying the cream, occlusive dressings should not be applied.

Contact with the mucous membrane of the eyes should be avoided.

In patients with liver failure, the functional state of the liver should be periodically monitored.

If signs of hypersensitivity or irritation appear, treatment is stopped.

If there is no effect within 4 weeks, the diagnosis should be confirmed.

Directions for use and dosage

Canesten spray should be sprayed externally and the cream should be applied, gently rubbing, onto previously cleansed and dried areas of the skin. Frequency of application – 2-3 times a day.

The duration of treatment is determined taking into account the type of pathogen and the nature of the disease. Average duration of therapy depending on the disease:

• Candidiasis of the external genitalia – 1-2 weeks;
• Dermatomycosis – 3-4 weeks;
• Tinea versicolor – 1-3 weeks;
• Erythrasma – 2-4 weeks.

Treatment of fungal diseases of the skin of the legs should be continued for another 2 weeks after the symptoms disappear.

Canesten tablets are intended for intravaginal use - they are administered in 1 piece. per day before bedtime, deep into the vagina while lying on your back. An applicator is included for ease of administration.

Duration of treatment depending on the dose of tablets:

• 100 mg – 6 days;
• 200 mg – 3 days;
• 500 mg – 1 day.

If the infection affects not only the vagina, but also the external genitalia, vaginal tablets are recommended to be combined with Canesten cream. For vulvitis associated with Candida spp., women should apply a small amount of cream to the skin of the perineum and external genitalia. For men with balanitis - on the foreskin and glans penis.

Composition of the drug

The active substance of Canesten cream is clotrimazole (0.01 g).

Excipients:

• Polysorbate 60 – intended to soften the skin;
• Benzyl and cetostearylone alcohols - ensure mixing of the components of the cream and its stability, and also allow the drug to penetrate to a sufficient depth;
• Cetyl palmitate has a cooling, healing and anti-inflammatory effect;
• Sorbinate stearate is an emulsifier aimed at softening the skin,
• Octyldodecanol – refers to fatty alcohols, stabilizes the composition and fixes the aroma, while additionally softening and moisturizing the skin;
• Purified water.

Analogs

Among the analogues, the following drugs deserve attention:

1. Kanizon - additionally contains the antibiotic gentamicin and betamethasone, which reduces the likelihood of allergies (manufacturer - India, price from 49 rubles);
2. Clotrimazole-Acri is a domestic analogue, which contains succinic acid, which increases the effectiveness of the drug (manufacturer - Russia, price from 31 rubles);
3. Clotrimazole-Akrikhin - castor oil, which is present in the cream, additionally soothes and softens the skin (manufacturer - Russia, price from 30 rubles),
4. Candida - the principle of action is to block the development of the fungus (manufacturer - India, price from 54 rubles).

Cheap analogues

Clotrimazole cream is the cheapest analogue. It is an active antifungal agent without additional impurities (manufacturer – India, price from 12 rubles).

Release forms and composition

Canesten is available in the form of cream, spray and vaginal tablets

Canesten is a drug based on clotrimazole. This active substance is the first-line drug of choice for diseases caused by yeast fungi of the genus Candida.

The drug Canesten is available in three forms:

• cream;
• vaginal tablets;
• spray.

The cream is intended for the treatment of skin infections. It contains clotrimazole (0.01 g of active ingredient per 1 g), alcohols, water, polysorbate. The cream is available in tubes of 20 g.

Canesten vaginal tablets and suppositories are available in two dosages - 100 and 500 mg of clotrimazole in one suppository (tablet). Auxiliary and formative components in the composition:

• lactic acid;
• lactose;
• calcium lactate;
• starch;
• shell components.

The drug in a large dosage (500 mg) is available in packages of one vaginal tablet. The product in a lower dosage (100 mg) is available in 6 tablets in a cardboard package. Each package contains applicators for convenient administration of the medication into the vagina.

The spray contains 1 g of clotrimazole per 100 g (1% solution) and excipients. It is available in 30 ml bottles.

Clotrimazole-based drugs can be purchased at pharmacies without a prescription. They are affordable and have a large number of analogues, which greatly facilitates treatment.

Instructions

Most often, the drug is prescribed for the treatment of skin mycoses in the form of a cream. Spray and vaginal tablets are used in the treatment of vaginal candidiasis and fungal infections of the groin area (in particular the mucous membrane of the external genitalia).

Instructions for use must be strictly followed by the patient during treatment. Changes in the scheme of use are permissible only as prescribed by a doctor.

For adults

Canesten cream is applied evenly to the affected surfaces in a small amount (5 mm should be squeezed out onto an area approximately equal to the palm of an adult). The product is used 2 or 3 times a day.

The cream can also be used for application to the external genitalia, provided it is well tolerated (no burning, irritation).

For mycoses that require long-term therapy, it is recommended to use Canesten for 10-14 days after the symptoms disappear (to prevent relapse).

• The spray is sprayed from a distance of 15-20 cm onto the infected areas 2-4 times a day. Also, in some cases, irrigation with the solution is combined with the use of the vaginal form of the drug.
• The tablets are inserted deep into the vagina once or twice a day. After administration, you should be in a horizontal position for at least 15-20 minutes (it is best to use them before bedtime). The duration of treatment depends on the prescribed dosage and the recommendations of the gynecologist.

Canesten in any dosage form should be applied only with clean hands to an area that has been previously cleaned of contaminants.

For children

There is no experience of use in children. Therefore, self-prescription of the drug is prohibited. The decision to treat a child with Canesten cream should be made by a doctor (vaginal forms, by definition, are not suitable for young children).

During pregnancy and lactation

Canesten can be used externally during pregnancy (in the 2nd and 3rd trimester) exclusively as prescribed by an obstetrician-gynecologist.

The use of any medications in the first trimester may entail a risk of disturbances in fetal development. Therefore, despite the lack of data on the embryotoxic effect of Canesten, it is worth abandoning it if it is possible to replace it with a safer drug.

Overdose

Abdominal pain signals an overdose

Canesten solution does not cause acute intoxication, since it does not have a systemic effect on the body. Canesten cream, used according to the instructions for use, also cannot cause an overdose.

An overdose is possible only if the drug, ointment, spray or vaginal tablets Canesten is accidentally swallowed. In this case, there is severe pain in the epigastric region, nausea, dizziness, and decreased blood pressure.

If you accidentally take the medicine orally, you must induce vomiting and take a sorbent. This is usually enough to relieve negative symptoms.