Grippferon: instructions for using drops and what they are needed for, analogues, reviews, price

Nasal drops based on interferon. Can be prescribed to children from a very early age. They have an immunostimulating effect. They are used topically and are not absorbed into the systemic circulation from the nasal mucosa. The drug fights the viral pathogen and also reduces the inflammatory process. Prescribed for therapeutic and prophylactic purposes for infectious diseases.

Dosage form

Grippferon is an immunobiological drug. It has an antiviral effect. The drug is used for the prevention and treatment of viral infections and respiratory diseases. The medicine is considered relatively safe. It can be prescribed to both adults and children.

The drug is available in the form of drops. The liquid may have no color or a light yellow tint. The medicine is packaged in bottles. They are made of plastic. The bottles are equipped with a dropper for easy administration of the product into the body. Containers with medication can have a volume of 5 or 10 ml. The bottle is placed in a cardboard package in which it is sold.

Indications and contraindications

Interferon entering the human body begins its therapeutic effect from the first minutes of penetration into the mucous membranes. The use of the drug is indicated for both emergency and prophylactic prevention of the development of ARVI in patients with a high risk of infection (being among sick people or virus carriers, weak immunity).

Indications for the use of Grippferon drops:

• therapeutic therapy of respiratory diseases caused by viral exposure (including influenza);
• preventive action to prevent the development of ARVI, when there is a seasonal increase in incidence;
• high risks of infection or disease development due to hypothermia, immunodeficiency.

Grippferon is indicated for use in preschool children, who often suffer from viral diseases due to their not yet fully formed immunity. Children who get sick more than 6 times a year can use this drug to reduce the frequency of illnesses. The use of drops can reduce the risk of contracting a viral infection, speed up the recovery process, and reduce the risk of complications.

Grippferon has quite a few indications that do not allow it to be used for any purpose.

Contraindications to the use of Grippferon:

• personal intolerance or high sensitivity of the body to the components included in the drug;
• severe allergic reactions.

Description and composition

The main active ingredient of the drug is human recombinant interferon alpha-2b. It acts as an analogue of endogenous interferon, which is produced by cells of the immune system. The effect of the drug is supplemented by excipients, the list of which includes:

• disodium edetate dihydrate;
• sodium chloride;
• sodium hydrogen phosphate dodecahydrate;
• potassium dihydrogen phosphate;
• povidone 8000;
• macrogol 4000;
• purified water.

Grippferon is active against most viruses that cause respiratory diseases. The drug can help in the fight against:

• influenza virus;
• parainfluenza;
• RS syncytial virus;
• adenovirus;
• rhinovirus.

Once in the human body, the drug affects viral particles located inside infected cells. The tool reduces replication processes. Grippferon stimulates the immune system against foreign agents. At the same time, there is a decrease in the damaging effect of immune cells that they have on their own tissues. Due to the influence of the drug, there is a decrease in the severity of the inflammatory reaction. This occurs due to the fact that the synthesis of inflammatory mediators is reduced.

Grippferon drops do not lead to the development of viral resistance and addiction. After instillation into the nose, the active substance of the drug practically does not enter the systemic bloodstream. It can be found there in small quantities.

Pharmacological properties

Viruses, once in the blood, reach cells and begin to increase in number there.
In this case, protective interferons are destroyed first. Grippferon actively helps to compensate for these losses. If you are late in taking it, changes such as:

• the appearance of pathological blood cells;
• dizziness;
• fatigue;
• insomnia;
• increased heart rate;
• skin rash;
• bowel dysfunction;
• cough and sore throat.

The first dose of medication may lead to:

• slight increase in temperature;
• muscle pain;
• weaknesses.

But after an hour, all this passes, and relief comes. After 2 days of intensive treatment with the drug, the disease stops progressing altogether, and the condition improves. Viruses gradually die and are eliminated.

The product effectively relieves:

• headaches;
• tickling and cough;
• runny nose.

The temperature returns to normal, and the nose begins to breathe normally. But you should not stop therapy immediately after improvement. You should strictly follow the entire course prescribed by your doctor. Sometimes it may exceed the 5 days recommended by the instructions.

Grippferon copes well with adeno- and rhino-coronaviruses. The active component of the drug, after instillation, has a negative effect on influenza and respiratory pathogens in the nasopharynx. This occurs due to prolonged contact of the drug with it.

Due to such close proximity:

• swelling disappears;
• runny nose is eliminated;
• the pain subsides;
• the temperature returns to normal.

Under the influence of an immunomodulator drug, lymphokines and antibodies are formed, and phagocytosis is activated. The active component of the drug stops the reproduction of pathogens.

The internal resources of the body under the influence of Grippferon stimulate natural immunity and get rid of viruses. A safe drug helps even small children and pregnant women.

The medicine used prevents pathogens from multiplying inside the body. On the second day of therapy, patients feel much better. And people who are near them do not have to be afraid of getting infected, since this will not happen.

Thanks to its optimal composition, Grippferon gently dries out mucus and gently gets rid of infection. The drug is administered at the first symptoms of infection to shorten the period of illness by almost 50%.

Prevention with a drug protects against flu and colds by 96%.

The positive properties of the medicine include:

• blocking the reproduction of viruses;
• proven effectiveness in treatment;
• lack of addiction;
• reducing the risk of complications after influenza and ARVI;
• the ability to use the drug during pregnancy and lactation;
• compatibility with many medications;
• maximum therapeutic effect;
• Possibility of taking together with vitamins;
• no adverse reactions.

The therapeutic effect of the drug occurs when:

• antiviral effects on pathogens;
• immune modulation;
• reducing inflammatory processes.

Indications for use

for adults

Grippferon is used for the prevention and treatment of acute viral respiratory infections. The drug can help with:

• parainfluenza;
• rhinovirus infection;
• adenovirus infection;
• flu;
• RS syncytial infection.

for children

Grippferon is used in pediatrics. It can be prescribed even to newborns. The drug is used for the prevention and treatment of acute viral respiratory infections. The product effectively fights most viruses.

for pregnant women and during lactation

The drug is approved during pregnancy and breastfeeding. It is prescribed for diseases resulting from the effects of viruses on the human body. When prescribing a remedy, the expected benefit for the expectant mother and possible harm to the child are taken into account. If there are individual contraindications, the drug is not used.

Other nasal antivirals

Oxolinic ointment

Antiviral agent for external use. One of the oldest antiviral agents. Appeared in the USSR in 1970, and is not recognized or registered outside the former CIS.

It is applied to the mucous membranes or skin and acts directly on viruses located on the mucous membrane before they penetrate into the blood. Oxolinic ointment is partially absorbed from the surface of the nasal mucosa and skin, but has no effect on viruses that have already entered the bloodstream. It also does not have any toxic, locally irritating or other harmful effects on the human body.

For the prevention and treatment of influenza and ARVI, 0.25% nasal ointment is intended; it is applied to the mucous membrane 3-4 times a day, both for the purpose of prevention during the period of increased incidence, and for treatment in the first days of the disease. 3% oxolinic ointment is intended for the treatment of viral skin diseases: warts, molluscum contagiosum, herpes.

Derinat Antiviral nasal drops

Refers to immunomodulators, inducers of endogenous interferon. First released in 1996 by CJSC FP Tekhnomedservice, Moscow. Derinat - sodium deoxyribonucleate - a medicine of animal origin (extract from sturgeon milt). Increases antibacterial, antifungal, antiviral immunity, and also activates the processes of restoration of damaged tissues.

Derinat stimulates T and B lymphocytes and macrophages (accelerates the metabolism inside these cells, resulting in increased activity, including accelerated synthesis of interferons and immunoglobulins).

Available in solution for intramuscular administration. It is used intramuscularly for severe diseases (tuberculosis, endometritis) as well as for rehabilitation therapy for burns, bedsores, trophic ulcers, and stomach ulcers.

For the prevention and treatment of influenza and ARVI, a 0.25% solution is used. For endonasal use, derinat is available in a dropper bottle.

Derinat, unlike interferons, is absorbed from the surface of the nasal mucosa and distributed along the lymphatic tract. That is, when used endonasally, this drug gives not only a local (at the site of application) systemic effect on the entire body. It can be used not only in the first days of illness, but at a later date: it restores immunity and promotes the restoration of damaged tissues. Allowed from birth.

For the treatment of influenza and acute respiratory viral infections, derinat is used for children of any age, starting from birth, and for adults according to the following scheme: the first two days, h/w every two hours, two drops in each nostril, 5-6 times a day, from the third day, two drops in each nostril 3-4 times a day until symptoms disappear completely.

For prevention: two drops 3-4 times a day throughout the entire epidemic. season. It is successfully used as a rinse for stomatitis, as eye drops for conjunctivitis and degenerative eye diseases. Derinat is also used for the treatment of acute respiratory viral infections and prolonged bronchitis and pneumonia in inhalation through a nebulizer. For inhalation take 0.25% derinat and saline. solution in equal proportions. Inhalations are carried out twice a day for 5 to 10 days. Nebulizer therapy has the greatest effect when the spray particle size is more than 5 microns. I hope

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Applications and dosages

for adults

The drug is used intranasally (dropped into the nose). After administering the medicine, you should massage the wings of the nose a little. The medication should be used when the first signs of a viral infection appear.

The duration of the course is 5 days. The dosage directly depends on the age of the person. So, adults should put 3 drops in each nostril 5-6 times a day.

The product can also be used for prevention. In this situation, the dose changes. If the drug is used after hypothermia or contact with sick people, it is necessary to instill Grippferon 2 times a day. The dose is determined depending on age.

If there is a seasonal increase in incidence, drops should be instilled into the nose once in the morning. The action is performed at intervals of 1-2 days. If necessary, the course of treatment with the drug can be repeated. Before the procedure, it is better to obtain a preliminary consultation with a specialist.

for children

If the patient is a child, it is imperative to take into account his age when determining the dose. The average dosage size is:

1. Children under 1 year of age - 1 drop in each nasal passage 5 times a day (daily dose 5000 IU).
2. Children from 1 year to 3 years – 2 drops in each nostril (2000 IU), 3-4 times a day (daily dose 6000-8000 IU).
3. Children from 3 to 14 years old - 2 drops in each nasal passage (2000 IU), 4-5 times a day (daily dose 8000-10000 IU).
4. Children aged 15 years and adults - 3 drops in each nostril (3000 IU), 5-6 times a day (daily dose 15,000-18,000 IU).

for pregnant women and during lactation

The dose is determined individually.

Actual effectiveness of the product

Grippferon ointment is known primarily due to the same name as the popular spray and drops. It is precisely as another “Grippferon” that it is sold out in pharmacies as a remedy for the flu. That is, it is the antiviral effect that its buyers (as well as many doctors) count on to the greatest extent.

It is also useful to read: Does Cycloferon help with the flu?

In fact, the effectiveness of interferon in suppressing viral infection has not been proven. This substance is not absorbed through mucous membranes, including the nose and digestive tract. Since the viral infection itself develops in the deep tissues of the mucous membranes and even outside them, in other organs, interferon must enter the blood in order to act on cells that are at risk of infection. If the product with it is simply applied to the surface of the mucous membrane, this does not happen (the interferon molecule is physically unable to pass through the channels in the mucosa due to its large size) and the product does not have any antiviral effect.

Today, the only known method of introducing interferon into the body in which the drug can have a therapeutic effect is intravenous injection. Even with this procedure, the effectiveness of such treatment has not been proven.

There have been no studies that would confirm that interferon administered into the body (including through the nose) is able to speed up recovery or protect the patient from complications of influenza. Nowhere in the world outside of Russia and the CIS countries are Grippferon or other interferon-based drugs used. WHO recommendations for the treatment of influenza do not list Grippferon or its analogues as recommended drugs for treatment.

At the same time, Grippferon really effectively suppresses the symptoms of allergic rhinitis. Loratadine is considered one of the most effective histamine receptor blockers. Its effect appears an hour after applying the ointment and lasts about 16-24 hours. During this time, the patient has a runny nose, sneezing and itchy eyes caused by hay fever.

Eyes of a child with typical allergic rhinoconjunctivitis

The antibacterial effect of boric acid and borax in the ointment is weak. These substances are considered outdated antiseptics and are much inferior in their effectiveness to modern means - Miramistin, Chlorhexidine and others. They can have some antimicrobial effect, in particular, it can be assumed that they can prevent bacterial complications in the nose after ARVI (although this effect has not been proven), but it is almost impossible to cure already developed bacterial rhinitis with green snot with their help.

The form of the product itself is also important: due to the fatty base, the ointment softens the mucous membranes when they dry out. This effect can be used when crusts appear in the nose and there is a risk of cracking. But you can’t apply ointment to your nose if snot flows out of it on its own - in this case, it is the fatty base that will disrupt the mechanism for removing mucus and lead to complete congestion.

Side effects

Grippferon is considered a relatively safe drug. Its use is allowed even for children and women who are pregnant or breastfeeding. However, after using the product, side effects are still possible. In particular, allergic reactions may occur. The risk of their occurrence increases significantly if the prescribed dosage is exceeded or the drug use regimen is violated.

If, after using the product, a person experiences side effects, or has symptoms that are not indicated in the instructions for the drug, you should immediately visit a specialist. Only a doctor will tell you how to act in each specific situation in order to eliminate possible harm.

Contraindications and side effects

The drug does not have any restrictions on use, except for individual intolerance to its constituent components. Along with this, do not forget about the age dosage and strictly follow the recommendations given in the instructions. The medicine can be used throughout the entire period of pregnancy and lactation.

At the moment, the instructions do not indicate any undesirable effects from using the medicine. In rare cases, an allergy to a component included in Grippferon is possible; no evidence of overdose has been identified. The instructions do not recommend the simultaneous use of vasoconstrictor drugs, as this will reduce the effectiveness of the drugs.

There are a large number of drugs that are analogues of Grippferon. The most similar of them are Interferon, Derinat, Genferon Light and Reaferon. The same pharmacological group includes Anaferon, Ronbetal, Viferon drops, Extavia and many other drugs containing interferon. It is strictly not recommended to independently select an analogue of the medicine, even for the treatment of a runny nose, without first consulting a doctor. After all, each of them has its own side effects and contraindications, even the almost similar Genferon Light and Derinat, and Anaferon, produced in tablets.

• Viferon is similar to Grippferon, but does not fully correspond to it, although it also contains interferon. Doctors often prescribe both of these drugs, which are often supplemented by Anaferon. Viferon is also approved for use in infants. Available in the form of a gel and ointment, there are also rectal suppositories similar to Grippferon Light.
• Derinat perfectly induces interferon, and is the closest analogue of Grippferon. Derinat has rapid absorption through the lymph nodes, and is used for the advanced stage of the disease, including the treatment of the common cold. Derinat is also an antiviral and antifungal drug.
• Genferon Light, the active ingredient of which is interferon, is available in the form of a spray and a drop in the nose. There are also rectal suppositories, which are an analogue of Grippferon. Genferon Light is approved for use for infants up to one year old and has no side effects.

Being a popular medicine, Grippferon is available in any pharmacy and its price varies from 215 to 450 rubles per drop. The price of the analogue Genferon Light candles fluctuates within the same limits, and the cost of Genferon Light in nasal drops starts from more than three hundred rubles. Derinat in the form of a 0.25% solution for topical use costs about 260 rubles per 10 ml bottle. In the form of injection solutions, Derinat costs about 1,750 rubles for 5 ampoules. The price of Interferon starts from 70 rubles and is sold in almost every pharmacy and is the cheapest. Anaferon, produced in tablets, costs about 200 rubles. The instructions for Anaferon recommend its use in a combination of drugs.

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Storage conditions

Grippferon is available without a prescription. It can be purchased at any pharmacy. The drug is suitable for use for 2 years from the date of its manufacture. The use of expired medications is strictly prohibited.

The product should be stored out of the reach of children. The sun's rays should not influence the medicine. The air temperature at the storage location must be maintained at a level of +2 to +8 degrees Celsius. Once the bottle is opened, it can be used for 30 days. Then the product becomes unusable.

What to choose: Grippferon drops or spray

The main advantage of Grippferon drops over the spray is that when instilled into the nose, the risk of infected mucus getting into the auditory tubes with the further development of otitis is practically eliminated. The drops slowly flow down the mucous membrane deep into the nose and more or less evenly wet its surface.

This is especially important for young children: their entrances to the auditory tubes are located close to the entrance to the nose, and the nostrils themselves are narrow. The pressure from the spray bottle can push some of the mucus into the Eustachian tubes, and pathogenic microorganisms or viruses from the mucus here will lead to inflammation of the inner ear

The pressure of the spray is sufficient to drive both it and some of the mucus into the child’s auditory tubes.

For adults, these dangers are less relevant: the distance to the auditory tubes is greater, and due to the width of the nasal passages, the pressure in the nose when injecting the product increases slightly. As a result, infection of the Eustachian tubes is unlikely.

This means that for children under the age of 5-8 years, Grippferon drops are definitely more preferable. Actually, this is why it is believed that the drops are specifically for children, although they can be used quite successfully by adult patients.

The spray is more convenient to use. It can be instilled while sitting upright or even standing. To do this, you do not need to lie down or throw your head back.

In addition, Grippferon spray spreads more completely throughout the nasal mucosa and is easier to dose. Therefore, this form is more convenient for adults.

Finally, you need to take into account the cost: the drug in drops is cheaper, and if the price of the drug is quite high, the savings can be significant for many patients.

There is also Grippferon ointment with loratadine. It is contraindicated for children precisely because of the presence in its composition of loratadine, an antihistamine component, on the basis of which some antiallergic nasal drops are produced. Therefore, Grippferon ointment cannot be considered as a full-fledged alternative to drops, although in some cases it is more preferable for use.

Analogs

There are many analogues of the drug Grippferon on sale:

1. Grippferon with loratadine is an antiviral agent that has an antiallergic effect. It is available in the form of a nasal ointment. It is prescribed for the treatment and prevention of acute respiratory viral infections, including those accompanied by rhinitis of allergic etiology. But the medication should not be taken by minors, pregnant or breastfeeding women.
2. Dry human leukocyte interferon is produced in the form of a lyophilisate by several domestic companies. Boiled water is added to it up to the mark and the resulting solution can be used in the form of drops in the nose of children from the first days of life. Inhalations can be done for adults and children from 3 years of age. The drug can be used during pregnancy and breastfeeding after consultation with a doctor.
3. Genferon Light is a combination drug containing taurine and interferon as active ingredients. It is produced in the form of an intranasal spray, which is recommended for the treatment of ARVI in children aged over 28 days to 14 years.
4. Infagel is an interferon-based antiviral drug. It is prescribed for the treatment of herpes infections and the prevention of influenza in adults. It is available in the form of a nasal gel.

Does Grippferon help in the prevention or treatment of coronavirus | ethnoscience

Grippferon is a medication that contains human interferon alpha-2b. The drug has antiviral activity, stops the inflammatory process, and develops resistance in the body to attacks by pathogenic microflora.

The listed properties have caused interest in whether Grippferon will help prevent or treat coronavirus. Despite previous experience with this drug, if there are signs of infection with the COVID-2019 strain, treatment is contraindicated without prior consultation with a doctor.

What is Grippferon

Grippferon is a medicine that comes in the form of a nasal spray (it is intended for irrigation of the mucous membrane of the nasal cavity). The drug is used as part of general medical prescriptions aimed at suppressing a viral infection, or used as monotherapy.

The drug is intended for the relief of acute respiratory viral infections and influenza that occur in children and adults or to prevent the development of these infectious diseases. The average duration of the therapeutic course is 5 days.

The drug Grippferon is included by the Government of the Russian Federation in the list of vital and essential drugs intended for medical use. The reason is the therapeutic effectiveness that can be achieved by the schematic use of a medicinal solution.

Why Grippferon is considered as a method of eliminating coronavirus

Despite the large number of deaths, experts emphasized that the invention of a vaccine will take at least 1 year. This is due to the peculiarities of developing a highly effective drug. During this period of time, the prevalence of coronavirus can reach wide limits.

To provide patients with the necessary level of medical care, experts decided to provide symptomatic treatment with an emphasis on antiviral therapy. The presence of interferon in the spray is recognized as a favorable condition for stopping the activity of the COVID-2019 strain.

There are several reasons why experts saw promise in using Grippferon for coronavirus infection:

1. Rapid achievement of a therapeutic effect.
2. Good tolerability (during treatment with Grippferon, side effects rarely occur).
3. Possibility of use during pregnancy (according to specialists, the component does not penetrate the placental barrier).
4. A small number of contraindications.
5. Possibility of safe use for the treatment of children.
6. Availability. The spray can be purchased without a prescription from a doctor.

Is Amiksin effective against coronavirus?

The pharmacokinetics of Grippferon is aimed at preventing the proliferation of pathogenic microflora in the blood. Taking into account the characteristics of the drug, experts decided to test it for the treatment of patients with coronavirus.

Infection with the COVID-2019 strain progresses in 2 forms: the first takes the form of severe acute respiratory syndrome (SARS), the second takes the form of atypical pneumonia. It is type 2 coronavirus that often leads to death.

Attention! Grippferon was studied only in relation to the elimination of the respiratory syndrome, which characterizes the COVID-2019 strain.

The drug reduces the viral load on the body and minimizes the risk of secondary transmission of coronavirus infection. Thanks to the interferon that the medication contains, it is possible to prevent the proliferation of pathogenic microflora in the patient’s blood. This reduces the severity of clinical manifestations of infection and improves overall well-being.

Can Grippferon be used to treat and prevent coronavirus?

Experts examined the activity of the antiviral spray Grippferon in relation to the relief of coronavirus, and came to the conclusion that the drug can be used as part of general medical prescriptions.

The medication relieves the main symptom of infection with the COVID-2019 strain – copious discharge from the nasal cavity. The symptom is accompanied by impaired breathing function, weakened sense of smell, and with regular exposure to interferon, these symptoms will quickly disappear.

Attention! The effectiveness of the Grippferon spray has been confirmed only for stopping the 1st form of coronavirus - SARS.

Studies have shown that in the prevention of the development of atypical pneumonia and the treatment of this disease, the use of a spray does not provide the expected effectiveness. The medicine suppresses the activity of pathogenic microflora localized in the upper respiratory tract, but pneumonia refers to a disease of the lower part of the respiratory system.

By using Grippferon, you can achieve partial relief, but the main active component of the spray does not stop the activity of the coronavirus progressing in the blood. It multiplies quite quickly, and the patient’s condition worsens. Experts recommend focusing on preventing the development of coronavirus infection:

• Wear disposable protective masks and replace them every 2 hours;
• Refrain from unjustified stay in crowded places;
• Treat hands with antiseptics;
• Disinfect the room with special solutions;
• Strengthen the immune system through vitamin therapy.

Despite the benefits of the drug, it is contraindicated for use without a specialist’s prescription, since the doctor takes into account the individual characteristics of the clinical case. Finding out if it helps

Grippferon for the prevention and treatment of coronavirus, experts have established: the drug can be used as part of antiviral therapy. But only when infection with the COVID-2019 strain progresses in the form of SARS, and the use of the spray has been previously agreed upon with the attending physician.

Source: https://happiness-and-beauty.ru/grippferon-dlya-profilaktiki-ili-lecheniya-koronavirusa.html