Nazoferon nasal spray. 5000 IU/dose 100 doses bottle No. 1

Pharmacodynamics and pharmacokinetics

The basis of Nazoferon is represented by a substance - recombinant human interferon alpha-2b . This component is characterized by inhibition of the replication of viruses - influenza, adenoviruses , and so on, by inhibiting the processes of transcription and translation. At the same time interferon exhibits an antiproliferative effect due to inhibition of the reproduction of cells that are infected with viruses, mainly RNA and DNA viruses.

Also noted is the ability of interferon to initiate the synthesis of protein kinase - a specific enzyme that prevents translation due to the processes of phosphorylation of its initiating factor. In addition, human interferon activates a specific ribonuclease , which has a damaging effect on the messenger RNA of the viral cell. Additionally, the production of other cytokines is stimulated, specific enzymes are induced, cell proliferation is inhibited, and an immunomodulatory effect is manifested as a result of increased phagocytic activity and the cytotoxic effect of lymphocytes directed towards target cells. Interferon alpha-2b is characterized by pronounced tissue specificity and relationship to immune mediators. At the same time, the substance provides the human body with reliable protection against many viruses, bacteria, pathogenic fungi, mycoplasmas and other pathogens of infectious diseases.

Nazoferon

Name: Nazoferon Pharmacological action: Antimicrobial, antiviral, immunomodulatory, anti-inflammatory action. Nazoferon is a drug based on recombinant human interferon alpha-2b. Interferon is characterized by the ability to inhibit the replication of viruses (influenza viruses, adenoviruses, etc.) by inhibiting the processes of translation and transcription. Interferon has an antiproliferative effect, inhibiting cell reproduction. Infected with viruses (mostly RNA and DNA containing viruses). Interferon has the ability to initiate the synthesis of protein kinase, a specific enzyme that prevents translation due to phosphorylation of the initiating factor of this process. Human interferon is capable of activating a specific ribonuclease, which has a damaging effect on the messenger RNA of the viral cell. Interferon also has the following effects: stimulates the production of other cytokines, induces specific enzymes, inhibits cell proliferation, has an immunomodulatory effect by enhancing phagocytic activity and increasing the cytotoxic effect of lymphocytes towards target cells. Interferon alpha-2b has pronounced tissue specificity and is classified as an immune mediator. Interferon, thanks to its abilities, provides the body with protection against viruses, mycoplasmas, bacteria, pathogenic fungi and other pathogens of infectious diseases.

Indications for use: Nazoferon is prescribed for the treatment of influenza, ARVI, colds in patients with frequent and long-term upper respiratory tract diseases, in children, starting from birth, in adults, including pregnant women. Nazoferon is used for the prevention of diseases in persons who are in direct contact with patients with influenza and acute respiratory viral infections, during hypothermia, during seasonal outbreaks of disease, in groups of children and adults, as well as during epidemics among at-risk groups - teachers, medical workers, etc. d.

Directions for use: Nazoferon must be administered into each nasal passage in accordance with the dosage regimen. For the best distribution of the drug in the nasal cavity, it is recommended that after instillation, lightly massage the wings of the nose with your fingers for several minutes. When the first signs of ARVI appear, incl. influenza (for five days) Nazoferon is prescribed: - for children under one year of age and newborns - 5 times a day, 1 drop (daily dose of the drug is 40,000 IU, single dose - 8,000 IU); - children from one to three years old - 3 or 4 times a day, 2 doses of spray (2 drops). Daily dose: spray is 20,000 IU, drops - 16,000 IU, single dose: spray is - 60,000-80,000 IU, drops - 48,000-64,000 IU; - children from three years to 14 years old - 4-5 times a day, 2 doses of spray (2 drops). Daily dose: spray is 80,000-100,000 IU, drops – 64,000-80,000 IU, single dose: spray – 20,000 IU, drops – 16,000 IU); — adults – 5-6 times a day, 3 doses of spray (3 drops). Daily dose: spray is 150,000-180,000 IU, drops - 120,000-144,000 IU, single dose: spray - 30,000 IU, drops - 24,000 IU.

Nazoferon for the prevention of ARVI is prescribed: - to persons who were in direct contact with patients with ARVI and in case of hypothermia - twice a day according to the age dosage for 6-7 days. Preventive courses can be repeated if necessary. In the case of single contact with a patient with ARVI, one injection (instillation) of the drug is sufficient; - during the period of seasonal increase in incidence: once in the morning according to the age-specific dosage with an interval of 1-2 days.

Side effects: When using Nazoferon, no side effects of the drug were identified. However, the possibility of allergic reactions in individuals with hypersensitivity to human interferon and other components of the drug cannot be ruled out.

Contraindications: Nazoferon is contraindicated in persons with hypersensitivity to the components of the drug, as well as in patients with a history of severe forms of allergic diseases.

Pregnancy: Nazoferon is safe and non-toxic, and therefore can be used during pregnancy and lactation.

Interaction with other drugs: When treating uncomplicated cases of ARVI, Nazoferon does not require additional symptomatic therapy (prescription of antipyretics, sulfonamides, vasoconstrictor drops, etc.). Nazoferon combines well with anti-inflammatory drugs when fever occurs. The simultaneous use of Nazoferon with intranasal vasoconstrictors is not recommended due to additional drying of the nasal mucosa.

Overdose: There is no data on cases of overdose of the drug Nazoferon.

Release form: Nazoferon nasal spray, in glass bottles 5 ml. Nazoferon nasal drops, in glass bottles 5 ml.

Storage conditions: Store at a temperature of 2-8 degrees Celsius. Keep away from moisture and light. After opening the bottle, store the drug for no more than 10 days.

Synonyms: Interferon alpha-2b.

Composition: 1 ml of Nazoferon contains: Not less than 100,000 IU of interferon alpha-2b. Excipients: trometamol hydrochloride, trometamol, hypromelose, lysine hydrochloride, disodium editate, methyl parahydroxybenzoate, potassium chloride, water for injection.

Additionally: Nazoferon is recommended for use by pregnant and lactating women to prevent acute respiratory viral infections in the early stages of pregnancy, when, due to intoxication of the maternal body, there is a high risk of developing fetal malformations.

Attention! The description of the drug “ Nazoferon ” on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Indications for use

The drug Nazoferon is prescribed for the treatment of:

ARVI;
flu;
colds , accompanied by frequent and prolonged illnesses in the upper respiratory tract.

In addition, this remedy is recommended for the purpose of therapy and prevention for pregnant women, for infants from the first days of birth, especially if they are forced to be in contact with people sick with influenza or ARVI. Also, as a prophylactic agent, the drug is used for hypothermia, during seasonal illness, and during epidemics in children's or adult groups.

Application Features

The drug contains methyl parahydroxybenzoate, which can cause allergic reactions, including delayed ones, and in exceptional cases bronchospasm.

The drug should not be used if the integrity and labeling of the packaging is damaged, if the physical properties (color or transparency of the liquid) change, or after the expiration date.

To avoid the spread of infection, individual use is recommended.

Use during pregnancy or breastfeeding.

Use is contraindicated.

The ability to influence the reaction rate when driving vehicles or other mechanisms.

Does not affect.

Instructions for Nazoferon (Method and dosage)

Nazoferon is intended for administration into each nasal passage, according to the established dosage regimen. In order for the product to be better distributed in the nasal cavity, after instillation, gently massage the wings of the nose with your fingers for several minutes. In pediatrics, Nazofen is actively used for children, produced in the form of drops. Instructions for children allow the use of this product even for the treatment of newborns.

Thus, the instructions for the drug recommend using Nazoferon for children when the first symptoms of ARVI or influenza . It is advisable to do this within the first 5 days. In this case, drops for children are prescribed to newborn babies and children up to one year old, 1 drop daily. Children 1-3 years old – 2 drops 3-4 times daily.

Nazoferon spray is recommended for use in older patients, both for prevention and treatment. On average, the course can last 6-7 days. If necessary, preventive courses are repeated. Single contact with ARVI patients allows only one injection or instillation of the drug. During an increase in seasonal incidence, a single use in the morning is prescribed, according to the age-specific dosage, with an interval of 1-2 days.

Price and analogues

The pricing policy for the sale of this drug depends on the form of release.

Spray can be purchased in the range from 370 to 400 rubles, and nasal drops - from 300-380 rubles per package.

Read this material on how to use Afrin spray to treat a runny nose.

The main analogues of this medication are the following drugs:

Grippferon

The drug Grippferon is an effective antiviral drug. Allows you to reduce the development of pathogenic microbes inside an infected cell, affects the elimination of viruses that provoke the occurrence of respiratory diseases (influenza, adenovirus, rhinovirus).

In addition, it creates conditions for strengthening the immune system against foreign bacteria, and also reduces the interaction of prostaglandins and other inflammatory mediators.

This medication can be used during pregnancy (with the exception of lactation).

Lipofer

Acts as a drug that contains the artificial protein “interferon”. Its action is aimed at increasing the protective functions of the human body. It is an antiviral drug for colds, flu and ARVI, used to treat allergic rhinitis (complicated by conjunctivitis), as well as bronchial asthma and other diseases.

Available in powder form for oral use. Contraindications include pregnancy and lactation, childhood (up to three years), individual intolerance to interferon and allergic reactions to the drug.

Laferon

The primary reason for use is the effect of the product on maintaining and stimulating the immune system, as well as providing an antiviral effect on bacteria. It is used in various areas: in the treatment of viral hepatitis B, acute respiratory diseases, during damage to the body by herpes, with chlamydia and damage to the nervous system, during myeloma, kidney and breast cancer and other areas.

Available in powder form for the preparation of nasal drops (the kit includes a dropper for administering the product). Contraindicated during pregnancy (no effects on breast milk during lactation have been identified). Treatment of children should be carried out only in accordance with the recommendations of a specialist. Side effects include chills, drowsiness, muscle weakness, and decreased appetite.

Interferon

This medicine is in the form of a powder for the preparation of drops (nasal use of the drug is intended). Contains synthetic human interferon. It is an effective treatment for eliminating signs of colds, flu and other infectious diseases. It is recommended to use when the first symptoms of the disease appear. This is due to the increased efficiency of the active substance.

Used during the treatment of children (the dosage and course of therapy must be agreed upon with the pediatrician). Among the contraindications clinically identified: depression, epilepsy, kidney and liver disease, autoimmune diseases, as well as individual intolerance to the substance in the composition.

Read how to use Snoop nasal spray to treat rhinitis here.

Interaction

During treatment with Nazoferon for uncomplicated cases of colds and acute respiratory viral infections , additional symptomatic therapy is not required, for example, taking antipyretic drugs, vasoconstrictors, sulfonamides, and so on. In this case, anti-inflammatory drugs may be prescribed to treat fever .

The simultaneous use of Nazoferon and intranasal vasoconstrictors helps dry out the mucous membranes of the nasal cavity.

Similar drugs:

Groprinosin Oral tablets
Choludexan Capsule
Lactobacterin siccum dry (Lactobacterin siccum) Lyophilisate for the preparation of solution for oral administration
Wobenzym Oral tablets
Anaferon for children (Anaferon filios) Lozenges
Ursosan Capsule
Bifidumbacterin Capsule
Immunoflazidum (IMMUNOFLAZIDUM) Syrup
Isoprinosine Oral tablets
Derinat Solution for injection

** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Nazoferon, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Nazoferon is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

If you are interested in any other drugs and medications, their descriptions and instructions for use, information about the composition and form of release, indications for use and side effects, methods of use, prices and reviews of drugs, or you have any other questions and suggestions - write to us, we will definitely try to help you.

Analogs

Level 4 ATC code matches:
Roferon A

Genfaxon

Inferon

Lipoferon

Laifferon

Intron A

Betaferon

Grippferon

Ingaron

Alfarekin

Laferon

PegIntron

Pegasis

Interlock

Interferon

Viferon

Infagel

Reaferon-Lipint

Reaferon-ES-Lipint

Reaferon-EC

The main analogue of this drug is Interferon alfa-2b.

Also have a similar effect: Arbidol, Amiksin, Viferon and others.

Nazoferon price in Kyiv

Nazoferon price

The price for Nazoferon is absolutely reasonable and this is a big plus. In Ukraine, Nazoferon is available and can be purchased at any pharmacy, after first checking the availability of the medicine.

Nazoferon price in Kyiv – from 59 to 103 UAH, depending on the pharmacy.
In Dnipro, the price of Nazoferon ranges from 65 to 106 UAH.
Price in Odessa – from 65 to 109 UAH.

As we can see, the price for the drug Nazoferon is approximately the same in all cities of Ukraine.

If you are unable to find the drug in your locality, Nazoferon can also be ordered from an online pharmacy and received by mail in your city.

To see the exact cost of Nazoferon in the cities of Ukraine, it is best to use a convenient website for searching for medicines https://tabletki.ua/Nazoferon/pharmacy/, where in the search field above the map you should select your city and the system will immediately give you all the pharmacies with addresses and prices of the requested product.

Reviews about Nazoferon

As you know, this drug can be used for children almost from the moment of birth. Therefore, reviews about it are found in large numbers on various forums on the topic of children and motherhood. At the same time, many parents give a fairly high assessment of the effectiveness of Nazoferon.

The result of treatment for young children is rapid relief from mucous discharge from the nose, elimination of swelling, and so on. In addition, this children's drug is an excellent prophylactic that protects against colds and infectious diseases. You can also find reviews about Nazoferon during pregnancy , which only confirm its effectiveness.

Interferon preparations are an indispensable and highly effective means of preventing and treating infectious and colds. However, it is not recommended to use them without a doctor's prescription. In any case, in addition to the urgent use of such remedies, it is important to try to strengthen the natural immune defense, then the person will need only minimal support.

pharmachologic effect

The action of the drug is aimed at combating viruses and microbes that can have a negative effect on the human body. It also has anti-inflammatory and immunomodulatory effects.

Due to the fact that interferon is present as an active substance in the composition, this drug creates an immune barrier for the body.

The effects of using the product include:

impact on preventing the replication of viruses;
stimulation of cytokine production;
inhibitory effect on cell proliferation.

Nazoferon price, where to buy

The price of Nazoferon for children in Moscow pharmacies is 374-390 rubles. The cost of the drug in the form of a spray is 400-420 rubles.

Children's Nazoferon can be bought in Kyiv pharmacies for 57.38 UAH, spray - for 67.16 UAH.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

LuxPharma* special offer

Nazoferon 100 thousand IU/ml nasal spray vial.
5ml 1360 rub. order

Pharmacy24

Nazoferon 100000IU/ml 5 ml nasal drops PAT "Farmak", Ukraine
78 UAH.order
Nazoferon 100000 IU/ml 5 ml No. 1 spray PAT "Farmak", Ukraine
78 UAH order

PaniPharmacy

liquid Nazoferon drops called. 100000 IU/ml vial. glass 5ml Ukraine, Farmak
71 UAH order
liquid Nazoferon spray called. 100000 IU/ml vial. glass 5ml Ukraine, Farmak
76 UAH order

“Nazoferon”, spray

Nasal spray 100,000 IU/ml, glass bottle 5 ml. The spray is actively used to relieve symptoms in patients aged one year or more, due to its convenient dosing mechanism and form, in which the active substance is sprayed evenly over the entire surface of the mucosa.

Mode of application

Method of administration: insert the tip of the spray bottle into the nasal cavity cleared of mucus, press the injection mechanism the appropriate number of times.

Instructions for using the drug “Nazoferon” to relieve symptoms of viral diseases:

Children under 1 year – 1 drop up to 5 times a day
Children from 1 to 3 years – 2 drops (spray doses) up to 4 times a day
Children from 3 to 14 years old – 2 drops (spray doses) up to 5 times a day
Children over 14 years of age and adults – 3 drops (spray doses) up to 6 times a day.

During the anti-epidemic regime:

In a work group, kindergarten, school - a single dose in the morning, according to age, every other day throughout the entire period of the epidemic
When in contact with an infected person - twice a day for a week, according to the age category.

Average price from 370 to 390 rubles.

Nazoferon drops

Nazoferon drops and spray have absolutely identical composition. Both types of drugs are produced in Ukraine. The only difference is that the spray, with one movement of the pump, injects into the nasal sinus a dosed stream necessary for one application of the medicine.

Nazoferon drops are produced without a spray bottle and are squeezed out by pressing with your fingers on the pipette.

If the spray is administered in a standing position, then Nazoferon drops, on the contrary, are taken in a lying position or with the head thrown back.

In any case, everyone chooses for themselves what is more convenient. The price of spray and drops is practically the same.

Nazoferon drops use

Nazoferon spray

In addition to the fact that Nazoferon spray is harmless and will provide you with easy breathing in a matter of minutes, it is also very convenient to use. Each press of the spray bottle delivers exactly one dose of the drug necessary to relieve a runny nose from the sinuses.

Nazoferon spray is a medicine based on recombined human interferon alpha-2b.

Nasal Nazoferon spray is produced and registered in Ukraine.

Nazoferon spray application

Nazoferon for children

Nazoferon for children is indicated for babies from 1 month. This is a great godsend for mothers whose babies suffer and cry from an ailment such as a stuffy nose.

Nazoferon dosage

Nazoferon for children, also known as nazoferon for adults. This drug is used to treat both adults and children.

Nazoferon children's price

The cost of Nazoferon is the same as described above. The availability of the drug in pharmacies in your city can always be viewed at the link https://tabletki.ua/Nazoferon/pharmacy/ The approximate cost of Nazoferon in the cities of Ukraine ranges from 65 to 109 UAH per bottle. The price for Nazoferon for children in different pharmacies is slightly different, and using the link above you can track and purchase Nazoferon drops or spray at a low price.

Release form and composition

The following dosage forms of Nazoferon are produced:

Nasal spray (in glass bottles of 5 ml);
Nasal drops (in glass bottles of 5 ml).

1 ml of spray or drops contains:

Active ingredient: interferon alpha-2b – not less than 100,000 IU (international units);
Auxiliary components: potassium chloride, trometamol hydrochloride, water for injection, methyl parahydroxybenzoate, disodium editate, lysine hydrochloride, hypromellose, trometamol.