Tyrosol, 50 pcs., 10 mg, film-coated tablets

• July 4, 2019
• Other drugs
• Ulyana Romanova

"Tyrozol" is a fairly well-known and widely used antithyroid drug. It shows impressive effectiveness in the treatment of thyrotoxicosis. What does it contain? How should it be taken? Are there any possible side effects? Now you should study in detail the instructions for use of "Tyrozol" and discuss everything related to this drug.

Pharmacodynamics and pharmacokinetics

Tyrosol is an antithyroid medication containing thiamazole , which disrupts the processes of hormonal synthesis in the thyroid gland by blocking the peroxidase enzyme involved in the iodination of thyronine to form triiodothyronine and tetraiodothyronine . This property of the drug makes it possible to carry out symptomatic treatment of thyrotoxicosis , in addition to cases of the formation of this pathology due to the release of hormones due to the destruction of the cellular structure of the thyroid gland (with thyroiditis or after the use of radioactive iodine ). At the same time, thiamazole does not affect the processes of release of synthesized thyronines , which explains the different duration of the latent period preceding the normalization of plasma levels of T3 and T4, which is an indicator of improvement in the clinical picture of the pathological process.

The effects of thiamazole in the thyroid gland are characterized by a decrease in basal metabolism, acceleration of the excretion of iodides , as well as an increase in the reciprocal activation of the processes of synthesis and secretion of thyroid-stimulating hormone by the pituitary gland, which may be accompanied by the development of thyroid hyperplasia .

A single dose of thiamazole continues to act for almost 24 hours.

Oral administration of thiamazole leads to rapid and almost complete absorption from the gastrointestinal tract. The time period for the drug to reach plasma Cmax varies within 0.4-1.2 hours. Binding to plasma proteins is negligible. Thiamazole accumulates in the thyroid gland, where it undergoes primary metabolic transformations. A certain amount of the drug is found in the milk of nursing mothers.

T1/2 of thiamazole takes from 3 to 6 hours and is prolonged with insufficiency of liver function . dependence of the kinetics of thiamazole on the functionality of the thyroid gland was revealed. Further metabolism occurs in the liver and kidneys. of thiamazole is excreted by the kidneys throughout the day , of which 7-12% falls to the unchanged drug.

Similar drugs

The drug under study is not expensive - its cost is about 350 and 180 rubles (for a drug containing 10 and 5 mg, respectively). But it’s still worth studying analogues of Tyrozol.

Instructions for use, indications and contraindications, side effects and everything else will be the same as in the case of the main drug, since all the products listed below have the same composition.

So, here's what you can replace this medication with:

• "Tiamazole". It has the name of the active substance and is a German substitute for Tyrosol. Also available in tablet form, it costs about 160 rubles less.
• "Mercazolil." One might say, a cheap drug made in Ukraine, which costs 25-45 rubles. Reduces basal metabolism, disrupts the synthesis of thyroid hormones, and also accelerates the removal of iodides from it.
• "Metizol". Rarely seen.

These were complete analogues in substance. But there are also drugs that have an identical effect. These include:

• "L-Thyroxine Berlin-Chemie". A synthetic preparation of thyroid hormone, used in complex therapy together with thyreostatics when the euthyroid state has already been achieved.
• "Euthirox". Synthetic levorotatory isomer of thyroxine. By the way, it is often prescribed to eliminate diffuse goiter. For thyroid dysfunction, the effect is observed 7-12 days after the start of administration.
• "Propitsil." A drug with a very strong thyreostatic effect, which interferes with the process of iodization of thyroglobulin. It also reduces the formation of the active form of iodine in the gland itself, blocking the peroxidase system.
• "Ultravist". It is a radiopaque non-ionic drug that is administered subarachnoidally, intracavity or intravascularly.
• "Somatulin Autogel". It is a synthetic analogue of somatostatin, which inhibits the secretion of TSH from the anterior pituitary gland and growth hormone.
• "Flutamide". An antiandrogenic agent belonging to the non-steroidal group.

In general, it is possible to find analogues of Tyrozol. However, the doctor will still deal with this. Self-medication is fraught with serious consequences; there is no need to put your health at even greater risk.

Indications for use

The drug Tyrosol is indicated for the following purposes:

• for therapy of thyrotoxicosis ;
• during the preparation of the patient for surgery on the thyroid gland for thyrotoxicosis ;
• while preparing a patient for treatment of thyrotoxicosis using radioactive iodine (radiiodine);
• in the latent period of radioiodine (prescribed before the onset of radioiodine for 4-6 months);
• for the prevention of thyrotoxicosis in cases where the patient is prescribed iodine (including radiopaque iodine-containing agents ), with autonomous adenomas , latent thyrotoxicosis or a history of thyrotoxicosis
• for the purpose of long-term maintenance treatment of thyrotoxicosis , when the general health of the patient or other individual reasons do not allow radical therapy (in exceptional cases).

What is it and what is it eaten with?

L-tyrosine is a precursor to the neurotransmitter dopamine. This is what determines its effect on mood and nervous state. With a lack of dopamine, we quickly get tired and experience decreased motivation. In addition, it is also a precursor of the adrenal hormones - adrenaline and norepinephrine.

We usually get L-tyrosine from protein foods. Most of it is found in chicken, turkey, seafood, avocados, almonds, milk, fish, soybeans, sesame seeds, beans, bananas, and pumpkin seeds. In addition, tyrosine can be synthesized in the body independently from another (essential) amino acid - phenylalanine.

Contraindications

The use of Tyrosol is absolutely contraindicated for:

• agranulocytosis during previous treatment with thiamazole or carbimazole ;
• personal hypersensitivity to thiamazole , auxiliary ingredients of tablets, as well as to thiourea ;
• granulocytopenia (including indications of it in the anamnesis);
• concurrent use of levothyroxine sodium during pregnancy;
• cholestasis observed before starting therapy;
• pathologies associated with sugar intolerance ;
• under the age of 3 years.

Relative contraindications to taking Tyrozol are:

• liver failure;
• formed goiter of significant size;
• narrowing of the trachea (only short-term therapy is possible in the preoperative period).

Side effects of Tyrosol

During treatment, the following side effects of Tyrosol were sometimes noted:

• temperature increase;
• agranulocytosis (symptoms of this pathology can appear even several weeks or even months after the start of therapy and cause the need to discontinue treatment);
• cholestatic jaundice;
• generalized lymphadenopathy ;
• enlarged salivary glands;
• thrombocytopenia;
• polyneuropathy;
• generalized skin rashes;
• pancytopenia;
• vomiting;
• Hirata disease with hypoglycemia;
• lupus-like syndrome;
• change in taste;
• weakness;
• dizziness;
• weight gain;
• neuritis;
• allergic skin manifestations ( redness , itching , rashes );
• development of alopecia ;
• toxic hepatitis;
• arthralgia (slowly progressing and without clinical manifestations of arthritis ).

What are people saying?

This is also worth talking about within the framework of the topic concerning the characteristics of the drug being studied and the instructions for use of Tyrozol. Reviews from patients who took it characterize the medication as a truly effective remedy.

They say that the drug cures thyroid disorders almost immediately. In a short time after use, improvements are observed - TSH normalizes, pulse drops, temperature levels out. In addition, fatigue, shortness of breath, headaches and arrhythmia disappear.

This result is due to the use of a loading dose in the first month - usually this regimen is indicated for most patients. Therefore, your well-being improves significantly after just a few weeks. To achieve complete remission, long-term treatment is often necessary (one and a half to two years), but after therapy, problems with the thyroid gland go away.

The only side effect that most patients report is weight gain, but it is minor. It is possible to add 1 kilogram per month at first.

But, however, many people still experience a decrease in the body’s defenses. However, this is not so much a side effect of the drug as a consequence of the disease. Still, the pathology exhausts the body, and to avoid this, it is necessary to consult with your doctor regarding the use of various fortified supplements.

Tyrosol, instructions for use (Method and dosage)

Instructions for use of Tyrosol involve oral (oral) administration of the drug tablets after meals (without chewing) with a sufficient volume of water.

The recommended daily dosage of Tyrosol can be taken once or 2-3 times. At the beginning of the therapeutic course, single doses of the drug during the day should be taken strictly at the same time. The maintenance dosage is indicated to be taken once a day, immediately after breakfast.

For the treatment of thyrotoxicosis , depending on the severity of the observed symptoms of the disease, 20-40 mg of Tyrosol is prescribed per day for 3-6 weeks. When the functional functioning of the thyroid gland normalizes, usually observed after 3-8 weeks of treatment, the patient is transferred to a maintenance daily dose varying between 5-20 mg. From this point on, it is additionally recommended to take levothyroxine .

Preparation for surgery for thyrotoxicosis requires a course of taking Tyrosol tablets in a daily dose of 20-40 mg, until the thyroid gland reaches a euthyroid state . From this point on, it is additionally recommended to take levothyroxine . To shorten the time period of the preoperative preparatory process, the patient is simultaneously prescribed iodine and beta-blockers .

When preparing a patient for therapy for thyrotoxicosis using radioactive iodine , it is recommended to take 20-40 mg of Tyrosol daily until the thyroid gland reaches a euthyroid state .

Tyrosol is taken during the latent period radioiodine treatment , depending on the severity of the disease, in a daily dose of 5-20 mg, before the onset of radioiodine , usually for 4-6 months.

Long-term maintenance thyreostatic treatment can take place in daily doses of 1.25 mg; 2.5 mg or 10 mg, with parallel administration of levothyroxine in small doses. Therapy for thyrotoxicosis usually takes 1.5-2 years.

In order to prevent thyrotoxicosis, when a patient takes iodine preparations (including iodine-containing radiocontrast substances ) in the presence of autonomous adenomas , latent thyrotoxicosis or indications of thyrotoxicosis in the anamnesis, 10-20 mg of Tyrosol is prescribed, together with 1000 mg of potassium perchlorate , at 24 hours. for 8-10 days prior to taking iodine-containing drugs .

The minimum permissible age for prescribing Tyrozol is 3 years. Patients aged 3-17 years are advised to take Tyrosol daily at an initial dose of 0.3-0.5 mg per kilogram of weight, divided into 2-3 equal doses. Adolescents weighing more than 80 kg can take a maximum of 40 mg of the drug per day. The maintenance dosage varies around 0.2-0.3 mg per kilogram of weight. If necessary, therapy is supplemented with levothyroxine .

When prescribing Tyrozol to pregnant women, they try to use minimal doses of the drug. The recommended single dose for pregnant women is 2.5 mg; The daily dosage is 10 mg.

In case of insufficiency of liver function, it is practiced to prescribe minimally effective doses of Tyrosol under constant medical supervision.

To prepare the patient for surgery for thyrotoxicosis , therapy with Tyrosol continues until the thyroid gland reaches a euthyroid state , usually for 3-4 weeks (sometimes longer) until the planned day of surgery and ends the day before surgery.

How to take the drug?

Having studied the side effects of Tyrozol, we can move on to consider the main issue. In general, all recommendations for taking this drug can be summarized as follows:

• The tablets should be taken after meals with a glass of water.
• It is better to divide the daily dosage into 2-3 times, but you can drink it at once.
• At first, you need to take the drug according to a strict schedule.
• If the doctor has prescribed the medication as part of maintenance therapy, then a single dose is sufficient - immediately after breakfast.

How much product should I take per day? This is not exactly stated in the instructions for use of Tyrozol. 5 mg and 10 mg are an indication of the amount of active substance, this nuance must be taken into account. Because based on this information, it is calculated how many tablets the patient will have to take per day. Depending on the severity of the disease, 20 to 40 mg per day is prescribed for 3-6 weeks. Everything is individual.

Typically, normalization of thyroid function is recorded within a period of 3 to 8 weeks. As soon as the endocrinologist notices the result, the patient is transferred to a maintenance dose. It varies from 5 to 20 mg. Levothyroxine is also prescribed additionally.

Overdose

In the case of prolonged use of thiamazole in high dosages, the formation of clinical and subclinical hypothyroidism , as well as the growth of the thyroid gland due to an increase in TSH levels, is possible. These negative effects can be avoided by additionally prescribing the patient levothyroxine sodium or reducing the dose of thiamazole until the thyroid gland reaches a state of euthyroidism . thiamazole therapy is discontinued, there is an independent restoration of normal thyroid function.

When taking ultra-high doses of thiamazole of myelotoxic phenomena may be observed . Therefore, taking the drug in such doses is allowed only if there are special indications ( thyrotoxic crisis , very severe course of the disease).

As a treatment for overdose conditions with thiamazole, discontinuation of ongoing treatment with its use, cleansing of the gastrointestinal tract and further relief of negative symptoms with the help of adequate medications are indicated. If necessary, transfer the patient to take an antithyroid drug from another group.

In childhood

When dysfunction or disruption of the synthesis of thyroid hormones is detected, this drug is often used in pediatric practice. The minimum permissible age of a child to prescribe the drug is three years. Patients from 3 to 16 years old can use the medicine in an initial dosage of 0.3 to 0.5 mg per kilogram of body weight, divided into 3 equal doses.

Teenagers who weigh more than 80 kg can drink a maximum of 40 mg of medication per day. The maintenance dose for a child varies from 0.2 to 0.3 mg per kilogram of weight. If necessary, the doctor can supplement therapy with Levothyroxine. The duration of treatment, dosage adjustment, and replacement of medication in case of poor tolerance can only be carried out by a pediatric endocrinologist.

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Interaction

If thiamazole after using high amounts of iodinated radiocontrast agents, its effectiveness may be weakened.

Iodine deficiency in the thyroid gland increases the effect of thiamazole .

Amiodarone lithium preparations , reserpine , beta-blockers increase the effectiveness of thiamazole , which may require adjustment of its dosage.

Patients undergoing treatment for thyrotoxicosis using thiamazole , after the thyroid gland reaches a euthyroid state (normalization of hormone levels in the blood plasma), may require a reduction in dosages of aminophylline and cardiac glycosides ( digitoxin , digoxin indanedione and warfarin taken together. and other anticoagulants that are coumarin .

Co-administration with Gentamicin increases the antithyroid effects of thiamazole .

The combined use of thiamazole with sulfonamides , myelotoxic drugs and metamizole sodium increases the risk of leukopenia .

The use of Folic acid and Leukogen while taking thiamazole reduces the possibility of developing leukopenia .

information on the effect of other medications on the pharmacokinetic and pharmacodynamic parameters of thiamazole . However, the acceleration of elimination and metabolism of substances observed in thyrotoxicosis , and therefore, it may be necessary to adjust the dosages of other drugs.

Tyrosine Supplements and Dosage Information

Tyrosine is available in powder form, capsule form, and is also found in some supplements for athletes. What are the reasons for taking a daily tyrosine supplement? Some of the most common reasons for taking tyrosine are to manage mood and symptoms of depression. And also increase energy and support weight loss.

Another reason to use a tyrosine supplement is to treat an inherited disease called phenylketonuria (PKU). In this condition, the amino acid phenylalanine cannot be properly converted into tyrosine, resulting in low levels. For people with PKU, it is best to get tyrosine from food and supplements. But there is very little phenylalanine in supplements because it cannot be artificially processed. Four to six grams of tyrosine per day is usually recommended for the treatment of PKU. Pregnant women with PKU should consume even more, up to 7.6g per day.

How much tyrosine should you take?

In most studies, adults safely took 100 to 150 mg per kg of body weight, which is equivalent to approximately 7 g per day for an adult. In some situations, higher dosages are recommended. For example, in stressful situations, to improve mental abilities, it is better to take 300 mg per 1 kg of body weight.

To increase alertness and prevent fatigue, it is recommended to divide the dose and take it in several stages. Depending on your health condition, your dosage may be individual. Therefore, it is better to start with a low dose and increase it as needed.

When should you take tyrosine?

For greater benefit, tyrosine should be taken on an empty stomach before meals. Because eating other amino acids may interfere with its absorption. Tyrosine may stimulate and potentially reduce sleepiness. Based on this, it is best to take it in the morning, and not in the evening before bed, and especially in large quantities.

How long does it take for tyrosine to take effect?

The effects of tyrosine in supplements can be felt in as little as 30-60 minutes, depending on the dosage and timing of the meal. Consuming this amino acid on an empty stomach has a faster effect.

special instructions

For patients who have a significant increase in the size of the thyroid gland , pressing on the lumen of the trachea , short-term administration of Tyrosol in combination with levothyroxine sodium , due to a possible increase in goiter and even greater compression of the trachea during long-term treatment. Such patients require careful monitoring with constant monitoring of the tracheal lumen and TSH levels, as well as regular peripheral blood tests.

Thiamazole , like thiourea , can reduce the susceptibility of thyroid tissue to radiation therapy .

In case of sudden appearance of increased body temperature , difficulty swallowing , sore throat , signs of furunculosis or stomatitis (possible symptoms of agranulocytosis ), it is necessary to interrupt therapy and immediately consult a doctor.

bleeding or subcutaneous hemorrhages of unknown origin, persistent nausea or vomiting , generalized rash and/or itching of the skin, severe epigastric pain , severe weakness, or are detected while Tyrozol , treatment should be discontinued.

Premature cessation of Tyrozol therapy may cause a relapse of the disease.

In case of correct treatment, the occurrence or worsening of endocrine ophthalmopathy is not associated with the side effects of Tyrosol.

In isolated cases, after completion of therapy with Tyrozol, the occurrence of late hypothyroidism , which is not a side effect of therapy, but is associated with destructive and inflammatory processes in the tissues of the thyroid gland, characteristic of the underlying disease.

Analogs

Level 4 ATC code matches:
Mercazolil

Tyrosol analogues can be divided into two groups, these are hormonal drugs that include thyroid hormones or their synthetic analogues (mainly levothyroxine sodium ): L-Thyroxine , Bagotirox , Eutirox , L-Tyroc , Thyro-4 , Triiodothyronine and drugs , affecting the synthesis and/or metabolism of thyroid hormones: Mercazolil , Iodomarin , Iodbalance , Microiodide , Thiamazol , Metizol , Propicil .

Propicil or Tyrosol?

Considering these two analogue drugs, it is worth noting that although they contain different active ingredients ( thiamazole for Tyrosol and propylthiouracil for Propicil ), they have a fairly similar mechanism of action in relation to the functionality of the thyroid gland. You can also trace similar contraindications and side effects of both drugs. Often, for example, if the patient has a personal hypersensitivity to one of the active ingredients of the drugs ( thiamazole or propylthiouracil ), one drug is replaced with another.

Judging by the reviews of patients, in the case of the use of Propicil , the positive dynamics of the treatment develops faster in comparison with Tyrozol, therapy with which, in turn, more often leads to long-term remission of the disease. In connection with all of the above, it is worth leaving the choice between these drugs at the discretion of the doctor, taking into account the individual characteristics of the patient’s body.

Composition and release form

The medication is a tablet drug sold in cardboard packages. Each of them contains 2 or 5 blisters with 10 pills (20 or 50 pieces, respectively).

The main active ingredient of "Tyrozol" is thiamazole. Additionally, the composition includes the following components:

• Sodium carboxymethyl starch.
• Hypromellose 2910/15.
• Lactose monohydrate.
• Magnesium stearate.
• Colloidal silicon dioxide.
• Cellulose powder.
• Corn starch.
• Talc.
• Titanium dioxide.
• Dimethicone 100.
• Macrogol 400.
• Yellow or red iron oxide.

What about the amount of active ingredient? There is "Tirozol" with 5 mg, and there is also a variant with 10 mg. Which one the patient should take depends on the individual characteristics of his body, as well as on the level of progression of the disease. In any case, only a doctor can prescribe treatment and further adjust the dose.

With alcohol

Despite the absence in the official instructions of contraindications to drinking alcohol during treatment with Tyrozol, such a combination a priori cannot lead to any positive aspects and, on the contrary, most likely, due to synergy , will cause an increase in the severity of side effects of therapy, and possibly even more severe ones reactions. In this regard, Tyrosol and alcohol are incompatible in the treatment of thyroid diseases.

Other nuances

Can Tyrozol be taken by children? The therapist prescribes this drug only to those younger patients who are over 3 years old.

Is it acceptable to drink alcohol while taking pills? Despite the fact that the instructions do not contain any contraindications for drinking alcohol, combining it with Tyrosol will not lead to a good result. On the contrary, most likely, adverse reactions will appear.

What about pregnancy? If therapy is not started while a woman is pregnant and suffering from thyroid disorders, her unborn child may suffer. In the best case, there will be an early birth; in the worst case, the baby will develop developmental defects or will not be born at all.

However, Tyrozol is prescribed to pregnant women in rare cases - usually mildly acting analogues are selected. Because thiamazole, which is part of the drug, penetrates the placental barrier and enters the fetal blood.

A pregnant woman can start taking Tyrozol if a full assessment of the benefits and risks of its use for both her and the fetus is carried out. But the dosages will definitely be prescribed to the minimum. The same applies to the use of medication during the lactation period.

During pregnancy and lactation

Untreated hyperthyroidism during pregnancy can cause serious complications, including fetal malformations and premature birth . In turn, hypothyroidism , formed as a result of the administration of inadequate doses of Tyrozol, can lead to miscarriage .

A characteristic feature of thiamazole is its penetration through the placental barrier , after which a drug concentration similar to that of the mother is observed in the fetal blood. For this reason, the prescription of Tyrosol during pregnancy can be justified only in extreme cases, after a full assessment of the benefits/risks of its use for the mother/fetus, in minimal effective daily dosages (up to 10 mg) and without parallel use of levothyroxine sodium .

Taking high doses of thiamazole a pregnant can lead to the formation of hypothyroidism and goiter in the fetus, as well as to a decrease in the child’s body weight at birth.

During breastfeeding, therapy for thyrotoxicosis in the mother can be continued in minimal dosages, since the concentration of thiamazole in breast milk corresponds to its content in the mother’s blood and can cause the development of hypothyroidism in the newborn. Taking Tyrosol by nursing women requires monitoring the functionality of the thyroid gland in newborns.

Doctors' comments

Above, the instructions for use and side effects of Tyrozol were studied in detail. Reviews from doctors about this product should also be given attention.

Many doctors say that this is the best medication for conservative treatment, which really helps in the treatment of hyperthyroidism. However, control, observation and a competent approach are required. If the patient uses the drug uncontrolled during self-medication, a negative result is possible.

But if everything is done in accordance with medical recommendations, the effect will be positive. "Tirozol" has a gentle effect on the thyroid gland, almost never causing side effects.

Experts also cite the pricing policy as advantages (not all patients want to pay a lot of money for medicines) and ease of use.

Reviews about Tyrozol

The main issue discussed in various forums created for the purpose of exchanging experience in the treatment of thyroid pathologies is the choice between drugs that include synthesized hormones and medications that affect the synthesis of endogenous hormones (including Tyrosol). Sometimes it is difficult for patients to understand the group affiliation of medications and decide on their future course of action regarding the need for treatment. The question of whether Tyrozol is a hormonal drug or not can be answered using the formulation of one of the doctors, in which he designated this drug as “a hormonal drug that does not include hormones or their synthetic analogues, that is, affecting hormones but not being such.”

Considering the reviews about Thyrosol on forums regarding the effectiveness of therapy with its use, one can note the positive attitude of patients towards its action, with references to the positive completion of the treatment and a long period of remission of the disease. Reviews of the side effects of Tyrosol most often come down to the problem of weight gain while taking pills, which, as a rule, returns to normal after the end of therapy. Also, some patients experienced allergic skin reactions , including itching, rash and hyperemia.

Side effects after taking the medication

What reactions may occur after taking Tyrozol tablets?
The side effects of this drug are described in each instruction. We will talk about them in more detail in this section of the article. In most cases, the drug mentioned is tolerated quite well by patients. However, it should be noted that sometimes while taking the medication, people may develop allergic reactions on the skin (in the form of itching, redness and rashes) and arthralgia, in addition, in rare cases, dizziness, weakness and vomiting may occur.

What other negative consequences can be caused by the drug "Tirozol"? Side effects and reviews of this medication are presented in this section of the article. So, we are talking about such unpleasant reactions:

• generalized lymphadenopathy;
• thrombocytopenia;
• neuritis;
• temperature increase;
• cholestatic jaundice, toxic hepatitis and arthralgia (develop very slowly);
• autoimmune syndrome together with hypoglycemia;
• pronounced enlargement of the salivary glands;
• pancytopenia;
• lupus-like reaction;
• changes in taste sensations of a reversible nature;
• agranulocytosis (manifests immediately or several months after the start of therapy, which leads to the need to discontinue the drug);
• polyneuropathy.

According to reviews from those patients who are taking or have ever taken this medication, it can easily cause weight gain. As a rule, such a negative effect occurs after taking large dosages of the drug.

Tyrozol price, where to buy

The average price of Tyrozol is: 180 rubles for 50 tablets of 5 mg and 350 rubles for 50 tablets of 10 mg.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Tyrosol tablets p.p.o.
  10 mg 50 pcs. Merck KGaA 317 rub. order
• Tyrosol tablets p.p.o. 5mg 50 pcs. Merck KGaA

  162 RUR order

Pharmacy Dialogue

• Tyrosol (tab.p.pl/vol.5mg No. 50)Merck KgaA

  RUB 171 order

• Tyrosol (tab.p.pl/vol. 10 mg No. 50) Merck KgaA

  RUB 338 order

  Read also:  Boric acid - use, purpose, contraindications

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Pharmacy24

• Tyrosol 5 mg N50 tablets Merck KGaA, Nimechchina
  131 UAH. order
• Tyrosol 10 mg No. 50 tablets Merck KGaA, Nimechchina

  213 UAH order

PaniPharmacy

• Tyrosol tablets Tyrosol tablets. p/o 5 mg No. 50 Germany, Merck KGaA

  162 UAH order

• Tyrosol tablets Tyrosol tablets. p/o 10 mg No. 50 Germany, Merck KGaA

  260 UAH order

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general information

Tyrosol is an antithyroid drug, the main component of which is the substance thiamazole. Produced by MERCK (Germany) in the form of tablets, each of which contains 5 mg or 10 mg of the active ingredient.

The following are used as auxiliary components:

• lactose,
• starch,
• cellulose,
• talc,
• hypromellose,
• silica,
• magnesium stearate,
• sodium starch glycolate,
• iron oxide red and yellow.

Tyrosol: properties of the drug

It is a means of symptomatic therapy and does not affect the causes of endocrine pathologies. In the human body, Tyrosol disrupts the process of binding iodine with tyrosine, which leads to a decrease in the synthesis of hormones.

It should be noted that the drug does not affect the release of already formed T3 and T4 into the bloodstream, which leads to a short latent period. In addition, Tyrozol is not able to bind and remove from the body thyroid hormones released during the breakdown of thyroid cells (during radioiodine therapy, thyroiditis).

Tyrosol tablets are absorbed quickly and almost completely. According to various data, the bioavailability of the drug is 95%. The maximum content in plasma is reached after 30 minutes - 1.5 hours. The substance is excreted through the kidneys, liver and to a small extent in unchanged form.