Psoriasis is not spread by contact with an infected person. Symptoms include psoriatic plaques. It is through them that the doctor diagnoses the disease. They can appear on the head, forming a psoriatic crown, on the legs, arms and body. They experience an inflammatory process, the appearance of red spots, redness, the skin dries and peels, and severe itching.
Stress often leads to psoriasis. Doctors also point to the causes of the disease as the aggressive influence of the immune system on cells, as a result of which they become pathological. It is impossible to cure the pathology, but it is possible to alleviate the course of the disease.
If you notice symptoms, immediately contact a specialist. It is important to undergo diagnosis in time and receive the necessary recommendations in order to relieve symptoms for a long time. Daivonex is one of the effective remedies. This is a safe medicine and has almost no side effects. The drug has several release forms, each with one main component.
Contraindications for use
Contraindications to the use of Daivonex include:
- hypersensitivity to the components of the drug;
- diseases and conditions associated with hypervitaminosis D and increased levels of calcium in the body;
- other forms of psoriasis, especially acute;
- severe kidney and liver dysfunction.
The drug is used with caution for kidney and liver diseases, in childhood and adulthood - treatment of patients under 6 and over 65 years of age with Daivonex is recommended only in cases where other methods of combating the disease are ineffective. People with a history of calcium metabolism disorders during therapy with Calcipotriol are recommended to undergo regular tests to monitor the content of the microelement in the blood and prevent possible complications.
People with a history of calcium metabolism disorders during therapy with Calcipotriol are recommended to undergo regular tests to monitor the content of the microelement in the blood and prevent possible complications.
Instructions for use
For effect, any of the dosage forms of Daivonex is applied to the affected areas of the skin and left to act until completely absorbed. Before starting use, you should thoroughly cleanse the skin, which will increase the effectiveness of the treatment.
Depending on the age of the patient, both the frequency of application and the treatment period may vary. To consolidate the positive result, as well as in case of relapse of the disease, periodic repetition of the course of treatment is allowed.
The instructions for the drug are described in detail in this video:
https://youtube.com/watch?v=ABWTl5gnVv0
For adults
For adults, the frequency of application of any dosage form is 2-4 times a day, while the ointment is applied as thin a layer as possible without subsequent rubbing into the skin. The thick consistency requires a longer time for absorption, however, it is with the help of ointment that doctors recommend treating skin areas with the most obvious and advanced symptoms of psoriasis.
The cream is also applied in a thin layer, its absorption time is short, therefore the cream also does not require rubbing. Adults should apply the cream to the affected parts of the skin 2-5 times a day. The duration of such treatment is on average 1.5-3 weeks, after which you should take a break and continue treatment if indicated by a doctor.
The Daivonex solution is also applied to the surface of the skin in affected areas; it does not require rubbing, since it has a short absorption time.
Children and newborns
Taking the drug in question is also allowed in childhood, but the process of its use should be supervised by the attending physician to prevent the occurrence of possible side effects due to the increased sensitivity of the child’s body to the active components of the drug.
The use of this drug is not recommended for newborn children.
Pregnant and lactating women
Since the active components of Daivonex do not penetrate the placenta and into the baby’s body, as well as into breast milk, its use during pregnancy and breastfeeding is allowed.
Daivonex price, where to buy
The price of Daivonex ointment in Russia is on average 1,200 rubles per 30 grams.
The price of ointment in Ukraine is on average 600 hryvnia.
- Online pharmacies in RussiaRussia
LuxPharma* special offer
- Daivonex ointment tube 30g
RUR 1,980 order
ZdravCity
- Daivonex ointment 0.005% 30gLEO Laboratories Limited
RUB 1,179 order
Adverse reactions
There are quite a few side effects that can occur when using Daivonex cream, ointment or solution. The most common reactions include the following:
- swelling of the face;
- allergic reactions (dermatological);
- depigmentation, which is reversible;
- hypercalcemia;
- periorbital edema;
- contact dermatitis;
- erythema;
- irritation of the skin at the site of application of ointment, cream or lotion;
- reversible hyperpigmentation;
- various types of rash;
- peeling of the skin;
- burning of the skin;
- itching;
- angioedema;
- eczema;
- exacerbation of the psoriatic process;
- dry skin;
- hypercalciuria;
- photosensitivity.
To eliminate such symptoms, the patient should increase fluid intake. Also, if adverse reactions occur, the patient is given hemodialysis (if renal failure occurs), forced diuresis, and also given corticosteroids and potassium chloride. At the same time, the daily volume of urine and the level of electrolytes are constantly monitored.
Release form and composition
Ointment 1 g
calcipotriol 50 mcg
excipients: disodium edetate; sodium hydrogen phosphate; α-tocopherol; liquid paraffin; polyethylene glycol stearate; propylene glycol; white paraffin; water
in tubes of 30 or 100 g; in a cardboard pack 1 tube.
Cream 1 g
calcipotriol 50 mcg
(equivalent to 52.2 mcg calcipotriol hydrate)
excipients: polyethylene glycol cetylate; cetostearyl alcohol; chloralylhexamine chloride; disodium edetate; sodium hydrogen phosphate; glycerol 85%; liquid paraffin; white paraffin; water
in tubes of 30 or 100 g; in a cardboard pack 1 tube.
Solution for external use 1 ml
calcipotriol 50 mcg
(equivalent to 52.2 mcg calcipotriol hydrate)
excipients: hydroxypropylcellulose; isopropanol; levomenthol; propylene glycol; sodium citrate; water
in bottles of 60 ml; 1 bottle in a cardboard pack.
Contraindications and side effects
The product is used in pediatric practice, but only in a hospital setting and under the supervision of a medical doctor. In most clinical situations, doctors try not to prescribe the drug to children, using effective analogues of Daivonex.
Contraindications for use:
- Ointment and cream should not be used for diseases characterized by a disorder of calcium metabolism, or with hypersensitivity to the active substance or auxiliary components;
- Daivonex solution is not recommended for organic intolerance, high concentration of calcium in the urine, kidney stones, hypervitaminosis D, against the background of a high level of free calcium in the blood.
Topical agents of any form are recommended with caution if the patient has a history of acute kidney failure. High risk of complications and side effects in patients over 65 years of age
Possible negative consequences:
- Swelling of the face.
- Depigmentation of a reversible nature.
- Erythema.
- Reversible hyperpigmentation.
- Itching, dryness and flaking of the skin.
- Detection of calcium in urine.
- Exacerbation of psoriasis.
- Various types of rashes.
- Skin irritations.
- Contact form of dermatitis.
- Dermatological allergy.
If side effects develop, the decision to further use Daivonex ointment or cream for the treatment of psoriasis is made by the attending physician. Most often, the patient is selected an analogue with the same therapeutic effect.
The drug Daivonex is strictly prohibited from being combined with other drugs (internal and systemic) that contain salicylic acid or its derivatives.
Is the drug hormonal or not?
Daivonex is considered a non-hormonal drug, since it does not contain steroids - analogues of adrenal hormones, which are part of many products used to treat dermatological diseases.
The main active ingredient of the drug is calcipotriol, which belongs to vitamin D derivatives, has high therapeutic activity, but does not have the side effects characteristic of glucocorticosteroids.
Release form and composition
Daivonex is available in easy-to-use forms. The doctor prescribes the procedure depending on the complexity of the case, the volume of the affected skin area, and the patient’s age.
It could be:
- Daivonex solution consisting of isopropanol, hyprolose, levomenthol, sodium citrate dihydrate, propylene glycol, pure water.
- Daivones cream has the following composition:
- cetostaryl alcohol;
- macrogol cetostearate;
- chlorallylmethenamine chloride;
- disodium edetate;
- dihydrate;
- sodium hydroxide;
- paraffins.
- Ointment - includes fewer auxiliary components and is made from macrogol stearate, propylene glycol, sodium hydrogen phosphate, vitamin E, and paraffins.
From the above it follows that there are 3 forms offered in pharmacy chains:
- Ointment for external use, mostly white, slightly transparent. Packaged in tubes of 30 or 100 g. Produced for sale in packs of cardboard.
- The cream for treating external surfaces is a white mass, with packaging and sales presentation identical to ointments.
- The solution for external use is a viscous, transparent liquid. It is packaged in 60 ml bottles made of polyethylene, more like a gel.
A dermatologist may prescribe a drug, but not focus on the dosage form. All three compositions have the same active ingredient, which is essentially the main
From this we can conclude that ointment, solution and cream are equally effective.
The ointment is saturated with fats and is well absorbed into the deep layers of the skin. Relieves symptoms of dry and overly sensitive dermis. To achieve a long-lasting effect, the ointment can be applied under a bandage. The only disadvantage of the drug used is oil on the skin, which can leave stains on clothes, as it has poor ability to be absorbed.
The cream consists of oil and water, which promotes better absorption. It does not stain things, is well absorbed by the skin, but in terms of depth of action it is somewhat inferior to ointment. Works well when necessary to relieve inflammation.
Lotion (solution) - convenient for treating skin with hair. Doesn't stain hair, doesn't leave a greasy shine.
Loma Lux Psoriasis is a modern medicine for the treatment of psoriasis of various forms. Read our article - Loma Lux Psoriasis.
Instructions for use, method and dosage, composition, release form, indications and contraindications, are presented in the material - Magnipsor ointment.
In this material we talk in detail about the drug Humira: indications and contraindications, features of administration.
Features of the drug
Having pronounced effectiveness when used in the treatment of skin lesions, accompanied by changes in the skin and disturbances in the functioning of the skin, Daivonex has a relatively small number of possible side effects even with long-term use. The doctor prescribes the drug after making a final diagnosis; the most commonly used drug for the treatment of psoriasis. By eliminating the main symptoms (flaking and itching of the skin, changes in its appearance, an increase in the affected area in the absence of adequate exposure), this remedy provides good results both in the initial stages of this disease and in its advanced forms.
Daivonex can be purchased without a doctor's prescription, which makes it easier to use.
However, it is the doctor who is able to draw up the treatment regimen that will be most effective and will help preserve the health of the skin, restore its normal appearance, and prevent relapses of the disease.
Dosage forms
A modern and balanced drug, Daivonex is offered for sale in several dosage forms, their composition is approximately the same, the degree of impact varies slightly.
Thanks to the ability to choose the type of drug, the possibility of its use is facilitated: in some cases, a certain type of drug will be most convenient. There are three varieties of Daivonex:
- An ointment that has a uniform white color and has the greatest density. Its use involves covering areas with visible negative changes in the skin of minor sizes, as well as with severe manifestations of dermatological diseases. Due to its increased density of the active substance content, the degree of impact of the ointment is greatest. The ointment is offered for sale in aluminum tubes, the volume can vary from 30 to 100 g, the tube is placed in a cardboard package with detailed instructions.
- Dayvonex cream has a less thick consistency and can range in color from white to slightly beige, which does not affect its medicinal qualities. The cream is used to treat large areas of damage, since it has a high degree of absorption and does not leave a greasy residue on the skin after absorption. This type of drug is produced in the form of an aluminum tube placed in a cardboard package, volume - 30 and 100 g.
- The Daivonex solution (lotion) is sold in the form of a 300 ml polymer package, has a light shade, and is transparent. The concentration of the active substance in the solution is high, which makes it, along with ointment and cream, highly effective even in the treatment of advanced forms of psoriasis.
The listed dosage forms of the drug are prescribed by the attending dermatologist for the treatment of many skin lesions accompanied by negative skin changes, but the drug in question shows the greatest effectiveness of treatment in eliminating the signs of psoriasis. Daivonex can be used both independently (with a combination of different forms) and in complex action.
Composition of Daivonex
The active substance of Daivonex is calcipotriol, which is contained in a concentration of 50 mg per 100 g of any dosage form. The excipients of the drug are purified and prepared water, glycerin, white paraffin, sodium citrate, levomethanol, propylene glycol, HPC.
This product is not hormonal, so it can be sold without a doctor’s prescription. The duration of use of Daivonex may vary depending on the degree of damage to the skin and the presence of concurrent skin diseases.
Price
The cost of the product is quite affordable, which allows it to be purchased by most buyers. The average price is 850-1250 rubles for a 30 g tube of cream or ointment.
In comparison with similar products, Dayvonex is not one of the cheapest, but due to its increased effectiveness, interest in it from buyers remains high, and reviews from those who have already used it to treat skin diseases, in particular psoriasis, indicate its high effectiveness even in advanced stages of the disease.
Analogs
An analogue of the drug Daivonex is Daivobet ointment. The composition simultaneously contains two active ingredients - calcipotriol in the form of monohydrate and betamethasone in the form of dipropionate. The medicine is recommended for the treatment of chronic plaque psoriasis. Contraindications include liver/kidney pathologies, pustular, guttate and exfoliative psoriasis, viral, fungal and bacterial diseases.
Unlike Daivonex, Daivobet is a hormonal drug, since betamethasone is a glucocorticosteroid. The duration of the therapeutic course is a maximum of one month. Use is prohibited during pregnancy and lactation.
Other analogues for therapeutic effect include:
- Psorkutan;
- Glenriaz;
- Xamiol;
- Psoriatic.
https://youtube.com/watch?v=_bJnhooHJxo
Reviews for Daivonex ointment and cream are varied. But most often there are negative opinions from patients. First of all, they are associated with the relatively high cost of the drug. Also, some note that the product did not help get rid of psoriatic plaques at all.
Daivonex is sold over the counter and does not require a doctor's prescription. The cost of the ointment (30 g) is about $22-25. The medicine should be stored at a temperature of up to 25 degrees. Once the tube is opened, the shelf life is 6 months.
Reviews from doctors and patients
Reviews of the treatment of psoriasis with Daivonex from doctors and patients are generally positive - they note a quick therapeutic effect and ease of use, and among the disadvantages of the product they name the rather high cost. At the same time, there are a small number of people who say there is no impact from the use of the medicine and the development of significant side effects.
Daivonex is considered one of the most effective modern drugs used to treat psoriasis, but its use can cause adverse reactions and complications, and therefore requires prior consultation with a doctor.
Terms and conditions of storage
Devonex retains its properties well at an ambient temperature of 25 degrees. The place is selected dry, without access to sunlight. Air circulation must be established in the room and safety measures must be taken into account to prevent contact of the substance with children. From the date of release, the drug can be used for 2 years, but after opening the tube, no more than six months.
Psoriasis is not a death sentence. The disease has no cure, but if you keep the course of the disease under control, you can significantly improve your quality of life and alleviate the symptoms. Experts have concluded that the use of ointments, creams, and Daivonex gel improves the therapeutic result and accelerates the healing process of lesions. The active substance is highly effective and is one of the primary medications for the vulgar form of psoriasis.
Patients note a positive result: the disappearance of itching and flaking, but there are also reviews with the opposite effect. Any changes in health caused by a therapeutic effect are a signal from the body to seek help from a doctor.
Side effects
On the part of the immune system, an allergic reaction, urticaria, and angioedema may occur.
Undesirable metabolic reactions occur extremely rarely and are mainly a consequence of dosage violations. These include hypercalciuria and hypercalcemia.
The most common reactions are from the skin and subcutaneous tissues: rash (pustular, bullous, scaly, erythematous, maculopapular), irritation, increased peeling and itching, increased dryness of the skin, burning, contact dermatitis, erythema. In some cases, an exacerbation of the disease is observed. Extremely rare are consequences such as reversible hyperpigmentation or depigmentation, facial edema, periorbital edema, and the development of reversible photosensitivity.
The occurrence of angioedema and facial swelling is most often associated with the use of Daivonex lotion. In the form of a solution, the drug can also lead to the following phenomena:
- increased itching and peeling of the skin;
- hyperemia of the treated areas;
- darkening of the skin;
- an increase in the level of calcium in the blood and urine is possible with long-term therapy and in the case of using a large amount of solution.
Daivonex. Side effects:
- Allergies, which include rashes and itchy skin.
- Symptoms of dermatological diseases may increase.
- Swelling of the face if the drug was used in lotion form.
- Eczema, contact dermatitis.
Please note that if side effects appear when using the drug twice a day or the patient begins to feel unwell, then the number of applications per day should be reduced to one. The maximum duration of therapy is two months. Use with hormonal agents is allowed.
In case of an overdose, it is possible to exceed the permissible calcium limit, muscle weakness, constipation, increased fatigue, and thirst. In case of overdose, Daivonex should be discontinued.
Indications for use of ointment, cream and solution
What is the drug “Davonex” used for, the price of which is indicated below? Most often, this drug is prescribed for monotherapy of a disease such as psoriasis, including the form that affects the scalp.
There are patient reviews that indicate that both stationary and regressive forms of the disease can be treated with this drug.
In addition, this medication is often used in the complex treatment of skin diseases together with drugs such as Acitretin, Cyclosporine and corticosteroids.
By the way, the Daivonex solution (lotion) is used only on areas with hair.
What does it help with?
The drug is recommended for use in vulgar and chronic psoriasis localized on the scalp. It helps eliminate psoriatic plaques, redness and rashes, is suitable for long-term use, and the effect is noticeable after a week of use, even in moderate and severe forms of the disease.
Contraindications
The drug is not prescribed:
- in case of hypersensitivity to calcipotriol and/or auxiliary components;
- in the presence of diseases accompanied by calcium metabolism disorders.
Daivonex ointment is not used in the treatment of psoriasis in children under 6 years of age. The purpose of the cream is not indicated until the age of 18, the lotion - up to 14 years.
Judging by reviews from doctors, the drug can lead to undesirable consequences when treating patients over 65 years of age, as well as in some pathological conditions and diseases. These include:
- vitamin D hypervitaminosis;
- hypercalcemia;
- hypercalciuria;
- nephrolithiasis;
- acute liver and/or renal failure.
In these cases, the drug is used with caution. During pregnancy and breastfeeding, the use of Daivonex is not indicated, since there is no reliable data on its safety for the fetus and the risk of calcipotriol passing into breast milk
During pregnancy and breastfeeding, the use of Daivonex is not indicated, since there is no reliable data on its safety for the fetus and the risk of calcipotriol passing into breast milk.
Pregnancy and lactation
Studies have NOT confirmed the negative effects of Daivonex dosage forms on women during pregnancy and breastfeeding. There is also no reliable information about the exposure of calcipotriol to infants in breast milk. Since the period of pregnancy makes the female body overly sensitive, the use of the drug is allowed only under the supervision of a leading specialist. Usually, the doctor prescribes any medications if it is impossible to do without them and the risk is justified.
special instructions
The active substance of the drugs is not so harmless and when applying Daivonex ointment, cream, lotion to the skin surface, you should follow the recommendations prescribed in the instructions.
Do not apply the substance to the face. After using the dosage form, hygiene rules should be observed.
It is important to prevent the medicine from getting into your eyes, nose, and mouth. If this cannot be avoided, it is necessary to rinse the fabrics with running, clean water.
The total area that can be covered with ointment should not be more than 30% of the total volume. In case of severe disease during treatment with Daivonex, constant monitoring of calcium levels in urine and blood tests should be carried out. Such patients with a complex course are more predisposed to the development of hypercalcemia due to the high absorption of the substance by the skin.
It is important to strictly adhere to the indicated dosages and not conduct experiments on your own health in order to prevent the situation from worsening. The simultaneous use of ointment and lotion is often prescribed
If the doctor misses the point, the patient must check that the total dosage of the active substance does not exceed normal limits
The simultaneous use of ointment and lotion is often prescribed. If the doctor misses the point, the patient must ensure that the total dosage of the active substance does not exceed normal limits.
When using the cream, you should remember that it contains cetostearyl alcohol. In some cases, the component can cause a reaction in the body in the form of a rash, redness, and burning.
During treatment, you should avoid direct contact with the sun's rays. Daivonex combines well with the action of an ultraviolet lamp, selective treatment, and PUVA.
Treatment using a photoactive substance together with the use of Daivonex, according to scientific research, has confirmed the positive dynamics of pathology during the manipulation process.
The ointment or gel is distributed over the surface of the skin once or twice during the day. Alternate use of cream and ointment is allowed
It is important not to exceed the recommended dosage and monitor for changes in health status. For areas with hair, use lotion
The frequency of PUVA procedures does not exceed 4 times a week. The first ultraviolet irradiation should not be more than 0.5 J per cm2. With each subsequent procedure, the UVA dose increases. Ammifurin acts as a photosensitizer. For visible results, it is necessary to undergo a course of therapy consisting of 10–20 sessions. Selective phototherapy also works well, with recommended repetitions up to 18 times.
The effect of Daivonex has been scientifically proven, since out of 40 patients with chronic psoriasis, with frequent exacerbations and a complex course, after a month's course of therapy with ointment and PUVA, more than half experienced complete elimination of symptoms. The treatment took place without complications, without worsening the clinical picture. Moreover, the duration of the remission stage increased and persisted for almost a year. Many refused corticosteroid therapy. Combined selective treatment and lubrication of lesions with the drug can reduce the radiation dose.
It should be noted that all forms of this drug do not affect the general well-being of the patient. Working with machinery and driving vehicles is quite acceptable.
Overdose
It is important to adhere to the instructions specified in the instructions, as well as follow the doctor’s recommendations. If an excess of the substance is applied beyond the norm, unpleasant symptoms may appear:
- loss of strength, fatigue;
- constipation, pathological changes in the intestines;
- impaired concentration;
- dry mouth, thirst;
- flaccidity of muscle fibers.
Signs of overdose appear when there is a high level of calcium in the blood. To restore parameters, the course of therapy should be interrupted.
pharmachologic effect
The active ingredient of the drug is an analogue of dihydroxycholecalciferol. Calcipotriol is a substance of synthetic origin identical to the active metabolite of vitamin D3. It interacts with certain keratinocyte receptors and stops the process of proliferation of skin cells
Thanks to scientific research, a version has emerged that the active substance blocks specific immune mediators, which is important for the treatment of psoriatic dermatosis
If we are talking about the diagnosis of psoriasis, Daivonex is prescribed to be able to influence interleukin, which contributes to the development of the disease.
Transdermal absorption does not provide good penetration of the active substance into the skin. Thus, 5% of the product enters the body, which eliminates the occurrence of systemic side effects. When it enters the liver, calcipotriol is converted into inactive elements of metabolic processes.
Many patients are sure that hormones provide a therapeutic effect; when asked whether Daivonex is hormonal or not, the answer can be answered with confidence - no. To achieve results, discipline and regular use are important.
Application to the skin with lesions of psoriatic ointments, solution, and creams for psoriasis Daivonex stops the spread process and gives a positive result within a week.
How to use the solution for scalp psoriasis
Daivonex solution is considered the most convenient means for treating psoriasis on the scalp (especially when it comes to treating women with long hair), since it is much easier to use than ointment or cream - the lotion does not tangle the hair and does not create the impression of greasiness. The drug is applied to the affected areas twice a day, lightly rubbing into the skin, the maximum weekly dose is 60 ml. If the solution is used in combination with a cream or ointment, the total amount should not exceed 90 ml per week - for example, 30 ml of solution and 60 ml of medicine in any form, or vice versa.
Psoriasis on the head
Description
Active substance
The active substance of Daivonex is calcipotriol, which is a synthetic analogue of dihydroxycholecalciferol, an active metabolite of vitamin D3. By interacting with special receptors in keratinocytes, the substance inhibits the proliferation of these skin cells and accelerates the process of their morphological differentiation. Experts believe that calcipotriol can also block specific immune mediators. We are talking, in particular, about interleukin 1, which presumably plays a significant role in the development of psoriasis. This is a rather significant additional factor in the mechanism of action of this drug for this dermatosis.
The difference between calcipotriol and other analogues of vitamin D3 is its lesser effect on the process of calcium metabolism in the body. Research shows that this effect is approximately 100 times weaker than with calcitriol.
The peculiarities of the dosage form cause poor penetration through the skin. Transdermal absorption reaches 1-5% of a single dose, resulting in no systemic side effects. In the liver, calcipotriol is rapidly transformed, forming pharmacologically inactive metabolites.
Excipients
The composition of Dayvonex cream includes: cetostearyl alcohol (consists of 60% cetyl alcohol and 40% stearyl alcohol), macrogol cetostearate, glycerol, chlorallylmethenamine chloride, sodium hydrogen phosphate dihydrate, disodium edetate dihydrate, sodium hydroxide, white soft paraffin (it contains approximately 10 ppm alpha-tocopherol), liquid paraffin, water.
The composition of Daivonex ointment for psoriasis is somewhat different from the cream. Its excipients are: macrogol stearate, propylene glycol, alpha-tocopherol, sodium hydrogen phosphate dihydrate, disodium edetate dihydrate, soft paraffin, liquid paraffin, water.
Auxiliary ingredients of the lotion: cetostearyl alcohol, macrogol cetostearate, chlorallylmethenamine chloride, glycerol, liquid paraffin, disodium edetate dihydrate, sodium hydroxide, white soft paraffin, sodium hydrogen phosphate dihydrate, distilled water.
pharmachologic effect
By stimulating the process of formation of leukocytes-T, the active substance of the drug Daivonex ensures the fastest penetration of substances necessary for the speedy restoration of the skin.
This eliminates excessive peeling of the epidermis and stimulates the protective properties of the skin. The active substance of this drug is a natural analogue of the active metabolite of vitamin D3, which protects the cell membrane from the negative effects of the causative agent of psoriasis. The therapeutic effect on the body consists in the preventive effect of the active substance on the process of proliferation of keratinocytes, which cause disturbances in the functioning of individual skin cells. Also, with the help of Daivonex, it is possible to achieve a pronounced improvement in psoriasis due to the activation of morphological differentiation, which has a positive effect on calcium metabolism in the body as a whole.
Pharmacodynamics
The process of disintegration of the drug when it enters the body occurs within 20-30 minutes, which provides the fastest result when starting treatment. The maximum concentration of the active substance in the skin is achieved within the first hour, actively affecting damaged areas of the epidermis, stabilizing all processes in the skin.
Biotransformation of the drug is carried out in liver cells, the process of therapeutic effects is carried out by already modified components of this drug. Quickly penetrating into the systemic bloodstream, the drug provides the most rapid and long-lasting effect, which is used in the treatment of even particularly advanced forms of the disease.
Pharmacokinetics
The half-life of Daivonex when applied to affected areas of the skin and then into the bloodstream is relatively short. Removal of decay products is carried out by the kidneys, partly by the gallbladder with bile.
Pharmacological characteristics
Daivobet is considered a comprehensive cure for psoriasis.
It has anti-inflammatory and antiproliferative effects.
The active components quickly penetrate into the deep layers of the dermis and begin to affect the source of the disease.
Calcipotriol reduces the height of papules, the intensity of redness and swelling.
The antiproliferative effect is based on the ability of the active component to inhibit the process of division of lymphocytes and macrophages. This eliminates psoriatic manifestations on the skin. Betamethasone relieves inflammation, itching, burning and pain.
Up to 2% of the drug enters the blood. Calcipotriol and betamethasone are removed from the body within 3-28 days.
What to choose
Often the attending physician prescribes the drug Daivonex, but does not specify the dosage form. Is there a difference between ointment, cream and lotion? The therapeutic effect of all three forms for psoriasis is based on the healing properties of the active component. Based on expert reviews, it can be argued that the product is equally effective regardless of the form of release.
Ointment. Contains the largest amount of fat, penetrates better into the skin, reaching deep layers. Great for dry and sensitive skin. To increase the depth of penetration of calcipotriol, the ointment can be applied under a bandage. The disadvantage of this dosage form is the insufficient absorption of fatty components into the skin, which is why they can stain clothes.
Cream. It is based on oils and water. After application to the skin, it is easily absorbed, does not leave a greasy sheen, and does not stain clothes. The depth of penetration of the cream is inferior to the ointment. Gives a good result when the inflammatory process is severe.
Lotion. It is a liquid dosage form based on alcohol and water. In the finished dosage form it is intended for the treatment of affected skin of the scalp. It is very convenient to use because it does not stain your hair at all.
Manufacturers of Daivonex recommend using ointment at night to eliminate rashes and plaques on the skin of the body, and cream in the morning.
Indications
A lotion is prescribed for the treatment of vulgar psoriasis of the scalp. It can be used as the basis of treatment or as an auxiliary medication as part of complex therapy.
Daivonex combines well with hormonal agents (glucocorticosteroids), targeted immunostimulants, and various physiotherapeutic procedures.
Description and instructions for the drug Daivonex
Daivonex is an anti-psoriatic drug. It contains calcipotriol, a substance similar to vitamin D. It is able to relieve inflammation and counteract pathological tissue growth in psoriasis
It is important to understand that Daivonex is not a hormonal drug, unlike most drugs used for this disease. Thus, having relieved the first manifestations of exacerbation of psoriasis with drugs from the group of glucocorticosteroids (Daivobet, Dermovate), you can continue treatment with this medication, minimizing the possibility of developing undesirable effects of hormones
Daivonex is used for:
Psoriasis, not excluding lesions on the scalp.
Daivonex has three pharmacological forms of release - solution, ointment and cream. All three forms should be applied to the affected skin in a thin layer (if you apply it thicker, the treatment effectiveness will not be higher!). The instructions for the drug determine the duration of therapy - up to two months. The ointment and cream can be used for patients starting from school age. The solution is intended for adult patients who need to act on psoriatic plaques under the hair. Be sure to follow the indicated dosages without exceeding them.
Daivonex is contraindicated for:
- Calcium metabolism disorders;
- Pregnancy and lactation, under the age of six years (there is no data on the safety of the drug for these groups of patients)
- with caution when -
- Nephrolithiasis;
- Excess vitamin D;
- Increased concentration of calcium in the blood;
- Treatment of elderly patients (over sixty-five years of age).
Daivonex – price
The cost of the drug in Moscow and regions may vary. The pricing policy is influenced by many different factors: location of pharmacies, rental of premises, popularity of the retail chain, convenience of the store location. In addition, the difference in prices for medicines is noticeable between pharmacy stalls and online stores. The pricing policy is influenced by the distance between the consumer and the country of origin.
Approximate cost of Davonex products in Russia and CIS countries:
| COUNTRY/FORM OF ISSUE | PACKING | PRICE |
| Russia Moscow | ||
| Lotion | 30 | 1700 rub – 2000 rub |
| Cream | 30 | 870 rub – 1100 rub |
| Ukraine, Kyiv | ||
| Ointment | 30 | 550 UAH – 945 UAH |
| Lotion | 30 | 1000 UAH |
| Belarus, Minsk | ||
| Ointment | 30 | 55 bel. rub |
