- November 5, 2018
- Other drugs
- Gena Poddubny
In the article we will look at the instructions for use of “Proserin” injections (intramuscular).
This is a synthetic type cholinesterase inhibitor, an effective and well-studied drug. This medication is one of the most important and necessary for human life. When properly prescribed, it works great and helps well in solving a wide range of different problems in the neurological field.
Despite many positive results, it is prohibited to use the drug without preliminary diagnosis and medical consultation. Proserin has quite a few side effects and contraindications for use.
pharmachologic effect
The pharmacological group of the drug is a cholinesterase inhibitor. This is a synthetic anticholinesterase drug that reversibly blocks cholinesterase. As a result of this action, acetylcholine accumulates and its effect on tissues and organs increases. As a result, neuromuscular conduction is restored.
Under the influence of the drug, the heart rate decreases, the secretion of the bronchial, salivary, sweat glands, as well as the glands of the digestive tract increases. In turn, this contributes to the manifestation of bronchorrhea, hypersalivation, and an increase in the level of acidity of gastric juice.
The active substance causes a spasm of accommodation , constriction of the pupil, lowers intraocular pressure , stimulates the tone of the smooth muscles of the intestines and bladder, tones the skeletal muscles, and provokes bronchospasm.
Prozerin is an antagonist of anti-depolarizing curare-like drugs. When taking large doses, the drug can provoke a disorder of neuromuscular conduction, which occurs due to the accumulation of acetylcholine. Produces a direct n-cholinomimetic effect. The effect of the drug coincides with the characteristic effects of excitation of cholinergic nerves. It does not cause central effects; compared to physostigmine, it provides more active stimulation of the muscles of the bladder, intestines, and uterus.
The effect on the heart is minor.
In childhood
The medicine can be prescribed to children of any age, but the dosage prescribed by the doctor must be strictly followed. Children under 10 years of age are prescribed 1 mg of the drug (suspension) per day. For adolescents over 10 years of age, the daily dosage is up to 10 mg. Proserin injections are prescribed to children under 12 years of age at 0.2-0.5 mg. The administration regimen and duration of treatment are determined individually by the attending physician. You should know that Proserinum for children in all dosage forms is prescribed only in a hospital setting.
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Indications for use of Proserin
There are the following indications for the use of Proserin:
- myasthenia gravis;
- paralysis;
- movement disorders after brain injury;
- recovery from polio , meningitis, encephalitis ;
- open angle glaucoma ;
- with intestinal atony, atony of the digestive tract as a whole;
- bladder atony;
- neuritis, optic nerve atrophy ;
- weak labor (in rare cases);
- in order to eliminate disorders of neuromuscular transmission with non-depolarizing muscle relaxants.
The use of the product for children is practiced in similar cases.
Contraindications
The medicine should not be used for the following diseases and conditions:
- hyperkinesis;
- epilepsy;
- arrhythmia, bradycardia;
- vagotomy;
- bronchial asthma;
- coronary heart disease (including angina pectoris);
- atherosclerosis ;
- stomach and duodenal ulcers;
- thyrotoxicosis;
- peritonitis;
- mechanical obstruction of the urinary tract or digestive tract;
- prostate hyperplasia;
- acute infectious diseases;
- intoxication in children weakened by disease;
- high sensitivity to neostigmine methyl sulfate .
Side effects
Injections and taking Proserin tablets can cause the following adverse reactions:
- digestion: diarrhea , hypersalivation, vomiting, flatulence , nausea, increased peristalsis;
- central and peripheral NS: dizziness and headache , blurred vision, weakness, miosis, drowsiness , convulsions, impaired consciousness, dysarthria, twitching of skeletal muscles;
- heart and blood vessels: tachycardia , bradycardia, arrhythmia, AV block, junctional rhythm, nonspecific ECG changes, decreased blood pressure ;
- allergic manifestations: itching , rash on the skin, facial flushing, anaphylactic manifestations;
- breathing: respiratory depression, increased bronchial tone, increased secretion of bronchial glands, shortness of breath ;
- other manifestations: increased urination, increased sweating, arthralgia.
Instructions for use of Proserin (Method and dosage)
Prozerin injections, instructions for use
The solution contained in the ampoules is used for subcutaneous administration in a dose of 1 ml 1-2 times a day. The largest single dose for subcutaneous administration is 0.002 g, per day - 0.006 g.
In order to use the medicine to stop the effect of muscle relaxants, atropine sulfate (0.5-0.7 mg) is initially administered intravenously, then wait until the pulse increases and after about 2 minutes 1.5 mg of Proserin is administered intravenously. If the effect is insufficient, a similar dose is re-administered. A total of 5-6 mg of the drug is allowed to be administered over about 30 minutes.
In ophthalmology, it is practiced to administer 1-2 drops into the conjunctival sac 1 to 4 times a day.
Oral administration is carried out at the rate of 10-15 mg 2-3 times a day for adults and 1 mg per day for 1 year of life for children under 10 years of age. The maximum permissible dose for adults is 50 mg per day, for children - 10 mg per day.
Reviews
Proserin is a well-studied and inexpensive drug; it has a good reputation among doctors, and therefore the solution is often prescribed to patients.
People note the following advantages in reviews of Proserin injections: affordable cost and high effectiveness, absence of complications and problems after treatment.
Other patients say that you need to be extremely careful with the medication, as it is not suitable for everyone.
Disadvantages include painful injections and, in some cases, difficult tolerability. Sometimes severe dizziness and nausea occur. The drug is very powerful and, if used incorrectly, can harm the patient. However, when prescribed correctly, it is effective and helps people perfectly.
Overdose
An overdose of the drug causes symptoms that are associated with the process of overexcitation of cholinergic receptors (the so-called cholinergic crisis). Hypersalivation, miosis, bradycardia, nausea, bronchospasm, diarrhea , frequent urination, general weakness, twitching of skeletal muscles and tongue, and decreased blood pressure .
In this case, you need to reduce the dose of the medicine or stop taking it completely. If there is such a need, the patient is administered Atropine , Metacin , as well as other drugs with an anticholinergic effect.
How does it work?
Electrophoresis is the effect of direct electric current on body tissue. At the same time, a medicinal substance is supplied from the electrode, which breaks down into ions. They penetrate the tissue and have the pharmacological effect characteristic of the drug. For each drug, the concentration is selected and the pole from which it will be administered is determined. For Proserin this is a 0.1% solution from the anode.
The action of the drug and the physiotherapeutic effect are summed up, which allows you to achieve great results. The resulting effect is determined by the mobility of particles in the field created by the device, as well as the concentration used and the area of influence.
The closer to the pathological process the procedure is performed, the better the technique works.
The percentage of the drug that penetrates tissue during electrophoresis does not exceed 10%. Scientists conducted an experiment that showed the inconsistency of the theory that a high concentration of the drug has a positive effect on the effectiveness of the procedure. This is due to the inclusion of ion braking forces for solutions of 5% and higher. It is called the Debye-Hückel phenomenon.
Due to the low permeability of solutions during electrophoresis, only strong drugs or electrolyte solutions are used for this method. Under the influence of current, drugs change, which adds new properties to them or enhances existing ones. Local exposure to the device ensures point accumulation of the active substance. This helps to avoid significant side effects that occur with systemic use.
Interaction
It should be borne in mind that neostigmine methyl sulfate is an antagonist of non-depolarizing muscle relaxants, therefore, when taken simultaneously, it activates the effect of depolarizing muscle relaxants.
If ganglion blockers, m-anticholinergic blockers, Novocainamide, Quinidine, local anesthetics antidepressants , drugs with antiepileptic and antiparkinsonian effects are used simultaneously, the effect of neostigmine methyl sulfate is reduced.
The effect of neostigmine methyl sulfate is potentiated when taking Ephedrine .
When taking neostigmine methylsulfate and beta-blockers, bradycardia may increase .
Conditions for dispensing from pharmacies
Dispensed by prescription.
ReplyReplyReplyReplyReply
I had the same thing as Marina. It’s not like you’re dying, but there were pains in your body all over + severe weakness. Reply Reply
This drug can be injected at home if prescribed by a doctor; it is not sold without a prescription. Keep in mind that this is not a remedy that can be used for treatment; prescribe it to yourself, at your own peril and risk. Reply
This drug can be injected at home if prescribed by a doctor; it is not sold without a prescription. Keep in mind, this is not a remedy that you can use to treat yourself; prescribe it yourself, at your own peril and risk.
ReplyReply
You are absolutely right, Stas.ReplyReply
I’m not allergic, but the reaction is unpleasant, it goes away quickly, I would have endured it since I needed it so much, but the doctor canceled it, it wasn’t enough, he says that you should move my horses here. So who cares ReplyReply
Nata, Prozerin is indeed used for diseases that are accompanied by the symptoms you described. You will agree that it is impossible to judge the correctness of the prescription remotely, without even knowing the diagnosis. In a situation where the side effect is so pronounced, you need to stop taking the drug and consult your doctor about this, he will either adjust the dose or select another drug. If it is not possible to get an appointment with him, try contacting him by phone. Reply
special instructions
Injections and tablets are used carefully for people with Addison's disease.
When administering the drug parenterally in large doses, Atropine must be administered simultaneously or pre-administered.
If during treatment a myasthenic crisis (due to an insufficient dose) or a cholinergic crisis (due to an overdose) develops, a careful differential diagnosis must be carried out due to the similarity of symptoms.
It is recommended to refrain from driving or engaging in other hazardous activities that require maximum concentration.
Analogues of Proserin
Level 4 ATC code matches:
Ubretid
Kalimin 60 N
Neuromidin
An analogue of this medicine is Neostigmine methyl sulfate . Analogues by mechanism of action are the drugs Armin , Amiridin , Deoxypeganine hydrochloride , Ubretide , Oxazil .
Prozerin price, where to buy
The price of Prozerin in ampoules is from 60 rubles for 10 ampoules. The price at which you can buy injections in Moscow depends on the manufacturer of the product. The price of Prozerin in tablets is from 55 rubles for 20 pcs.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Prozerin solution for in.
0.5 mg/ml 1 ml 10 pcs. JSC Novosibkhimpharm 82 rub. order - Prozerin tab. 0.015g No. 20 JSC Dalkhimfarm
57 RUR order
Pharmacy Dialogue
- Prozerin (amp. 0.05% 1 ml No. 10) Novosibkhimpharm OJSC
73 rub. order
show more
Pharmacy24
- Prozerin-Darnitsa 0.05% 1 ml No. 10 solution PrAT" Pharmaceutical company "Darnitsa", Ukraine
20 UAH. order
PaniPharmacy
- Prozerin ampoule Prozerin solution d/in. 0.05% amp. 1ml No. 10 Ukraine, Health of the people LLC
19 UAH order
- Prozerin ampoule Prozerin solution d/in. 0.05% amp. 1ml No. 10 Ukraine, OZ GNTsLS LLC
19 UAH order
- Prozerin ampoule Prozerin solution d/in. 0.05% amp. 1ml No. 10 Ukraine, Darnitsa ChAO
20 UAH order
show more
Release form and composition
- Tablets: flat-cylindrical, white, chamfered (10 pieces in blister packs, 2 packs in a cardboard pack);
- Solution for injection: colorless transparent liquid (1 ml in neutral glass ampoules, 10 ampoules with an ampoule knife or scarifier in a cardboard pack, or 5 or 10 ampoules in a blister pack, 1 or 2 packages with an ampoule knife or scarifier in a cardboard pack; if ampoules with a break point or break ring are used, the ampoule knife/scarifier is not included in the packaging);
- Solution for intravenous (IV) and subcutaneous (SC) administration: colorless transparent liquid (1 ml in ampoules, 10 ampoules with an ampoule scarifier in a cardboard pack or 5 ampoules in blister packs, 2 packs with an ampoule scarifier in a cardboard box).
Active substance – neostigmine methyl sulfate (prozerin):
- 1 tablet – 15 mg;
- 1 ml solution for injection – 0.5 mg;
- 1 ml of solution for intravenous and subcutaneous administration – 0.5 mg.
Auxiliary components of the tablets: potato starch, calcium stearate monohydrate, sucrose (sugar).
Additional substance of injection solutions: water for injection.
