Comparison of the effectiveness of Amlodipine and Amlodipine-teva
The effectiveness of Amlodipine is quite similar to Amlodipine - this means that the ability of the drug substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Amlodipine is more pronounced, then using Amlodipine-teva even in large doses will not achieve this effect.
Also, the speed of therapy - an indicator of the speed of therapeutic action - is approximately the same for Amlodipine and Amlodipine-teva. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Negative consequences
According to WHO data on the incidence of side effects, when taking this medicine they develop in rare cases. The following manifestations are observed:
- headache;
dizziness;- nausea;
- vomit;
- flatulence;
- tinnitus;
- skin itching and rash;
- dyspnea;
- a sharp decrease in blood pressure;
- insomnia or increased sleepiness.
In some cases, pain in the chest area, increased anxiety and depression, alopecia, amnesia and urticaria may occur.
If the dose is exceeded, a sharp drop in blood pressure may occur, leading to hypotension and the appearance of reflex tachycardia. It is necessary to perform gastric lavage using activated charcoal or similar agents.
Comparison of the safety of Amlodipine and Amlodipine-teva
The safety of a drug includes many factors.
At the same time, in Amlodipine it is quite similar to Amlodipin-teva. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Amlodipine, as well as Amlodipine-teva, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Amlodipine does not have any risks when used, just like Amlodipine-teva.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Amlodipine and Amlodipine-teva.
general information
Amlodipine-Teva (INN - amlodipine) is a calcium channel blocker, which belongs to the drugs of the modern generation. Leads to relaxation of the heart due to a decrease in pressure on it, reducing the need for oxygen. Widely used in cardiac therapy due to its high efficiency and gentle effect on the body. Allows you to normalize the patient’s well-being and reduce blood pressure for up to 24 hours.
Dosage form and prices for the drug
The product is available in the form of round, biconvex, white, film-coated tablets. Depending on the mass of the active substance, “AB5” or “AB10” is applied to one of the sides. The second side remains smooth. The drug is packaged in blisters of 10 pieces. A cardboard box may contain 1 or 3 blisters.
The medicine should be stored in a cool place, protected from direct exposure to sunlight, and should not be used after 5 years from the date of release. It is also necessary to limit children's access to ensure safety.
The price of the drug depends on the number of blisters in the package and the pharmacy where the drug is purchased. The average cost is 95-220 rubles. A doctor's prescription is required for purchase.
How is it different from Amlodipine?
At first glance, there is no difference in the drugs - they both contain the same active ingredient. But this is not so - the drug is significantly different from Amlodipine. Amlodipine-Tev is produced at the factories of a Hungarian company, taking into account modern Israeli pharmacological technologies.
Mechanism of action of blockers
An imported manufacturer produces a drug of higher quality - it contains a minimum amount of impurities and additives, which allows the main substance to work more efficiently, reducing the likelihood of side effects.
Due to the difficulty and energy consumption of the purification process, the cost of the drug increases. That is, Amlodipine-Teva is more expensive, but has higher efficiency and less intensity of side effects compared to its analogue.
Composition and mechanism of action
Amlodipine besilate (in terms of Amlodipine 5 or 10 mg) is the main active ingredient that is included in the tablets and determines their mechanism of action. It has a direct effect on the smooth muscles of blood vessels, which leads to their relaxation, improved blood and oxygen conductivity, and a decrease in pressure.
Additional components of the drug are:
Microcrystalline cellulose. Prevents the formation of sclerotic plaques and removes cholesterol from the body.- Anhydrous calcium hydrogen phosphate. Strengthens the walls of blood vessels and produces an anti-inflammatory effect.
- Sodium carboxymethyl starch (type A). Acts as a disintegrant to shape tablets.
- Magnesium stearate. It has a calming effect on the nervous system and strengthens the walls of blood vessels.
To improve the absorption of the drug, lactose is used. The medicine is absorbed from the gastrointestinal tract over a long period of time, regardless of food intake. The elimination of the drug is slowed down in older patients (over 65 years), but this is not dangerous. The absorption period after a single use is 12-18 hours.
Properties
The drug blocks slow calcium channels, which significantly improves heart function and normalizes blood pressure. In doing so, it produces the following effect:
reduction in the severity of ischemia;- reducing myocardial oxygen demand with its simultaneous supply;
- restoration of coronary blood flow;
- reducing the likelihood of angina pectoris;
- preventing spasm of the coronary arteries.
The use of the drug can reduce the likelihood of death, the chance of chronic heart failure and the frequency of surgical interventions for patients with a history of coronary artery disease.
Blood pressure decreases 3-6 hours after taking the medicine. The effect persists when you maintain a lying or sitting position for 24 hours after administration.
Comparison of addiction between Amlodipine and Amlodipine-teva
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “syndrome o” in Amlodipine is quite similar to the similar values in Amlodipin-teva. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Amlodipine has a fairly low incidence of “syndrome”, just like Amlodipine-teva.
Rules for administration and dosage
The tablets are taken orally, regardless of time or meal. The optimal amount of water is 100 ml, and the dose is 5 mg. To be effective, one dose once a day is sufficient.
The instructions for use note that if there is no pronounced effect for two to three weeks, it is necessary to increase the volume to 10 mg. There is no need to adjust the dosage in older patients or in those who suffer from renal failure.
Stopping should be done gradually due to the risk of increasing the intensity of angina attacks. If the dose is increased, you should drive carefully, as dizziness may occur.
During therapy, it is recommended to monitor and control body weight, as well as visit the dentist to avoid bleeding and pain in the mouth.
Comparison of side effects of Amlodipine and Amlodipine-teva
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Amlodipine has more adverse events than Amlodipine-teva. This implies that the frequency of their occurrence is low with Amlodipine and low with Amlodipine-teva. Frequency of manifestation is an indicator of how many cases of an undesirable effect from treatment are possible and registered. The undesirable effect on the body, the strength of influence and the toxic effect of drugs are different: how quickly the body recovers after taking it and whether it recovers at all. When using Amlodipine, the body's ability to recover faster is higher than that of Amlodipine-teva.
Indications and restrictions
The drug can be used both as an independent treatment and as a component in complex treatment. Main indications for use:
- AH 1st and 2nd degree;
- dilated cardiomyopathy;
- angina at rest (vasopastic) and angina at exertion.
Dilated cardiomyopathy
There are a number of contraindications for which the use of the medicine is not recommended:
- hypotension;
- cardiogenic shock;
- unstable forms of angina;
- hypersensitivity to the components of the product or individual intolerance.
Children should not take pills because their effects on the child’s body are poorly understood. Pregnancy is a contraindication - use is only possible if absolutely necessary, according to the conclusions of the attending physician. During lactation you should not use the drug.
Comparison of ease of use of Amlodipine and Amlodipine-teva
This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.
The ease of use of Amlodipine is approximately the same as that of Amlodipine. However, they are not convenient enough to use.
The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.
Last update date: 2020-12-04 13:48:15
Compatibility with alcohol and other drugs
As part of combination therapy, the effect of the drug is enhanced when taken with the following groups of drugs:
- diuretics;
- ACE inhibitors;
- alpha-blockers.
Interaction with other drugs
You cannot combine the medicine with beta-blockers - there is a risk of exacerbation of heart failure. When used with drugs and local anesthetics that work similarly, the hypotensive effect is enhanced. When drinking alcohol, the effect of the tablets does not change, although it should be excluded for safety.
Side effects
In the cardiovascular system, effects such as:
- swelling of the feet and ankles;
- tachycardia;
- severe decrease in blood pressure;
- inflammation of the vascular walls, postural hypotension;
- formation or worsening of heart failure;
- decreased heart rate;
- migraine;
- painful attacks in the chest area;
- damage to the heart muscle.
From the nervous system the following are possible:
- cephalgia, dizziness, apathy, weakness;
- fainting, lethargy, sleep disturbance;
- trembling fingers;
- restlessness, depression, irritability;
- amnesia, uncoordinated muscle movement (extremely rare).
In the area of the digestive system, the side effects are as follows:
- the occurrence of pain in the abdominal area;
- feeling of thirst;
- dry mouth;
- overgrowth of gum tissue;
- excessive appetite;
- inflammation of the liver, jaundice, inflammation of the pancreas;
- inflammation of the gastric mucosa;
From the musculoskeletal system the following may appear:
- pain in the back area, muscles, joints;
- decreased joint mobility;
- pathological weakness and muscle fatigue.
Side effects from the genitourinary system are as follows:
- painful urge to empty the bladder;
- erectile dysfunction;
- frequent urination at night;
- urinary disorder, increased urine production.
In the respiratory tract:
- itching of the skin, appearance of a rash;
- nettle fever;
- multiform exudative redness of the skin.
- losing weight or becoming overweight;
- ear noise;
- inflammation of the conjunctiva;
- chills;
- skin inflammation;
- bleeding from the nose.
Reviews about the drug AMLODIPINE
Name:
Mohamed Ashur
Review:
The doctor told me! It’s better to take one AMLODIPINE tablet per day now than six later... But I didn’t specify! and I didn't think to ask. Should they be taken constantly, or as a course of treatment? Please answer if anyone knows. Thanks a lot…
Name:
Alexey Zverkov
Review:
amlodipine should be taken constantly. no courses
Name:
Nelja Linkova
Review:
the doctor told me that only when the pressure rises. Perhaps this is just my case.
Name:
Adelka
Review:
READ THE SIDE EFFECTS, THIS IS POISON.
Name:
NZ
Review:
I agree with Adelka.
Name:
Vladimir
Review:
Adelki - prescribed by specialists from the hospital, or self-medicate from the Internet? Who to believe?
Name:
Anatoly Voronchikhin
Review:
Only amlodipine normalizes my blood pressure, there are no side effects. My head hurts a little, but maybe it’s not from the pills...
Name:
Michael
Review:
Problems with potency began to develop. My feet were also very swollen. After the cancellation the situation was restored. I advise men to ask doctors to select other medications.
Name:
Tamara Nekrasova
Review:
Today I just found out that amlodipine is analgin, phenobarbital, papaverine and dibazole together. The doctor said that there is nothing to significantly reduce blood pressure, so a hair dryer apparently does this, and it is also in Carvalol (a component of general anesthesia).
Name:
Sergey Zhurin
Review:
I’ve been drinking for a month, no effect. I increased the dose. I take 10 mg in the morning and evening.
Name:
Vladislav polyandra
Review:
I take enalopril in the morning on an empty stomach and in the evening I take amlodipine, so I brought my blood pressure down from 210 to 110 to 130 to 80
Analogs
If a drug is unavailable, it can be replaced with a similar pharmacological action. Among the analogues are:
- Amlotop (140-160 rub.);
- Tenox (300-550 rub.);
- Normodipine (450-1100 rub.);
- Kalchek (200-450 rub.);
- Amlorus (30-95 rubles).
It is necessary to use similar medications only after consultation with a cardiologist.
