pharmachologic effect
The active component of the drug, dydrogesterone, is an analogue of natural progesterone . Duphaston is a hormonal drug.
Under the influence of this medicine, thermogenesis is not disrupted in a woman’s body, so basal temperature can be measured to determine ovulation. The product does not affect metabolic processes in the body or liver function. Dydrogesterone is very similar in properties and structure to natural progesterone. However, the drug does not provoke the side effects that occur when taking a number of synthetic progesterones. Wikipedia indicates that this drug does not have androgenic, estrogenic, anabolic, thermogenic, or corticoid effects. As a component of hormone replacement therapy for menopause , the drug provides a positive effect of estrogens on the lipid profile blood . But if estrogens have a negative effect on the blood coagulation process, then dydrogesterone has no effect on coagulation.
When taken orally, there is a selective effect of dydrogesterone on the endometrium , which helps prevent the high risk of hyperplasia or carcinogenesis, provoked by increased production of estrogen. The medicine does not have a contraceptive effect. During treatment, the drug does not affect ovulation. Menstruation also continues as usual when taking the medication. A woman can become pregnant with dydrogesterone and maintain pregnancy during treatment with the drug, since no negative effect on the fetus is noted during the treatment process. There is a selective effect on progestin receptors of the uterine mucosa. It does not affect the ovulation of the follicle. There is no masculinizing or virilizing effect.
Since the natural hormone dydrogesterone reduces the level of excitability of the myometrium, under its influence the contractile activity of the uterus decreases. The answer to the question of whether this drug affects weight is clear: taking Duphaston does not contribute to gaining extra pounds.
Thus, dydrogesterone reduces the effect of natural estrogens on the body, therefore it is successfully used for infertility , PMS, recurrent miscarriage, menopause , in women who have already had a frozen pregnancy , etc.
How does duphaston work?
The active ingredient of Duphaston is dydrogesterone. One tablet contains 10 mg. A feature of dydrogesterone is its similarity in structure, chemical and pharmacological effects with natural progesterone. Since dydrogesterone is not a derivative of testosterone, it does not cause the side effects inherent in most synthetic progestogens derived from androgens (excessive hair growth or deepening of the voice).
Also, the drug does not have anabolic activity (does not increase protein synthesis and muscle mass), does not affect the production and metabolism of glucocorticoids and temperature, including basal temperature (for example, when taking COCs, there is no point in measuring basal temperature). Dydrogesterone supports the beneficial effects of estrogens on blood lipids, but differs in that it does not affect blood clotting. Also, dydrogesterone does not have a negative effect on carbohydrate metabolism and liver function.
Dydrogesterone replenishes the deficiency of its own progesterone in the body, that is, it promotes the “unfolding” of the second phase of the cycle - it loosens the endometrium, preparing it either for implantation of the egg or for rejection (menstruation). Thus, duphaston reduces the increased risk of endometrial hyperplasia or cancer due to excess estrogen, which is observed with long and regular delays in menstruation.
Pharmacokinetics and pharmacodynamics
After oral administration, dydrogesterone is rapidly absorbed from the gastrointestinal tract; after 2 hours the highest concentration of the active component in the blood is observed. The degree of binding to blood proteins is 97%. 56-79% is excreted from the body by the kidneys; a day after administration, about 85% is excreted from the body; the entire excretion process is completely completed after 72 hours. Metabolites are present in urine , mainly in the form of glucuronic acid conjugates .
There is no data on changes in the pharmacokinetics and pharmacodynamics of the active component in people who suffer from kidney disease. Does not accumulate.
Deciphering pharmacological properties
The effect of Duphaston begins approximately one hour after administration. At this moment, an increase in progesterone levels is observed in the body. It is worth noting that the drug does not contain additional female and male hormones: estrogens and androgens.
The drug is excreted in the urine. The absence of traces of the drug can be observed within three days after the last dose of the tablet. The amount of dose received does not determine the time it takes for the substance to be removed from the body.
The half-life of the drug begins to be observed after about ten hours, which is why, to maintain a constant concentration in the human body, repeated doses of the drug are prescribed at regular intervals.
Indications for use
Why Duphaston tablets are prescribed depends on the diagnosis and treatment regimen determined by the doctor.
Currently, the following indications for use of the drug are determined:
- Insufficiency of progesterone in the body (in case of infertility associated with insufficiency of the luteal phase, with the threat of miscarriage or habitual loss of the fetus, with dysmenorrhea , menstrual cycle disorders, amenorrhea of secondary origin).
- As part of hormone replacement therapy (during menopause, it is used to neutralize the proliferative effect of estrogens on the mucous membrane of the uterine cavity when using estrogens; during surgical castration).
Thus, tablets are prescribed for dysfunctional uterine bleeding, for polycystic ovary syndrome , for corpus luteum cyst, for endometritis, for uterine fibroids .
What else the medicine is prescribed for, when it is prescribed, and what the dosage should be, you should ask your doctor.
Analogs, are there more effective drugs?
Duphaston analogues:
- Progesterone. It has a broader, non-selective pharmaceutical effect. Used in more severe clinical cases, when the main drug is ineffective.
- Ingesta. Progesterone analogue.
- Oxyprogesterone capronate. It has a narrow scope of application: uterine bleeding, lack of menstruation.
Which is better, Duphaston or Utrozhestan?
Both drugs are synthetic versions of progesterone. The pharmaceutical activity is essentially identical. Utrozhestan is less likely to cause side effects and is cheaper. Otherwise the difference is insignificant. It is possible to replace one remedy with another in case of intolerance or insufficient individual effectiveness.
Contraindications
There are contraindications for taking Duphaston.
First of all, you should not take pills if you are highly sensitive to dydrogesterone or other components of the drug, as this can harm the woman’s body.
The tablets should be prescribed with caution to women who have suffered from itching during pregnancy before.
There is no data on the negative effects of dydrogesterone on people who suffer from chronic renal failure
Side effects of Duphaston
During the reception process, some side effects of Duphaston may be observed:
- immune system: hypersensitivity (very rare);
- hematopoietic system: hemolytic anemia (isolated cases);
- nervous system: migraine , headache ;
- hepatobiliary system: minor liver dysfunction, which may cause weakness, jaundice, abdominal pain;
- reproductive system : breakthrough bleeding during administration (rare), prevented by increasing the dosage of the drug; the sensitivity of the mammary glands may increase;
- subcutaneous tissue, skin: itching, urticaria (rare), Quincke's edema (very rare);
- general disorders: peripheral edema (very rare).
If any of the above symptoms occur, you should tell your doctor that this side effect is occurring.
Instructions for use of Duphaston (Method and dosage)
The drug is prescribed according to an individual regimen, both when planning pregnancy and for gynecological diseases. It doesn’t matter how you take it, before or after meals.
Duphaston tablets, instructions for use
The indicated dosage regimens are indicative only. To prescribe a treatment regimen and determine how long the pills can be taken, the doctor must take into account the symptoms of the disease and the phases of the monthly cycle. The daily dose of the medicine should be divided into 2-3 doses, tablets should be taken at equal intervals.
Duphaston for endometriosis is prescribed in a dose of 10 mg of dydrogesterone 2 or 3 times a day. How to take Duphaston for endometriosis depends on the doctor's prescription. You need to take the product from days 5 to 25 of the cycle or do it without a break. It should be borne in mind that only the attending physician can prescribe Duphaston for endometriosis. Reviews from doctors on the Internet or any medical forum with information about treatment should be taken only as information for reference.
Duphaston for conception in case of infertility of progesterone origin is prescribed from the 11th to the 25th day of the monthly cycle. You should definitely find out from a specialist how to take Duphaston for conception. As a rule, treatment lasts for 3-6 months. How to take Duphaston to get pregnant, how much you need to drink to get pregnant, depends on the woman’s diagnosis and the individual characteristics of her body.
If there is a delay after taking the pills and other signs of pregnancy while taking the drug, treatment should continue, and the dose should be equal to that prescribed for a habitual pregnancy loss.
If a woman has a threatened miscarriage or recurrent pregnancy loss , it is advisable to use the medicine only if there is clear evidence of endogenous progesterone deficiency. Women with threatened abortion are advised to take a single dose of 40 mg of dydrogesterone, followed by 10 mg every 8 hours for a week. Then the dose is gradually reduced. But if the threat of miscarriage arises again, the dose is increased. Application can be practiced until the 20th week of pregnancy. But more precisely, your doctor will advise you individually about which week to take the pills during pregnancy.
How to take if there is a threat of miscarriage in the early stages , the doctor determines individually. As a rule, in case of recurrent miscarriage at the stage of pregnancy planning, Duphaston is taken from the 11th to 25th day of the cycle, provided that conception has occurred, the woman continues to receive the same dose. Further, after the 20th week of pregnancy, the dose should be gradually reduced.
Women suffering from PMS are prescribed 10 mg tablets from days 11 to 25, treatment lasts from 3 to 6 months.
Duphaston for delayed menstruation , irregular cycles and other menstrual disorders is prescribed from cycles 11 to 25, 2 times a day, 20 mg. How to induce menstruation with Duphaston depends on the woman’s diagnosis. The doctor prescribes the drug for irregular cycles, determines how to take Duphaston to induce menstruation, how much to drink to induce menstruation. Whether it is possible to induce menstruation with amenorrhea depends on the correct treatment. As a rule, taking Duphaston in this case is combined with taking estrogen . This treatment should be practiced for at least three monthly cycles.
In case of dysfunctional bleeding, the drug is prescribed 10 mg twice a day for 5-7 days, combining the dose with 0.05 mg ethinyl estradiol . In order to prevent the development of bleeding, tablets are prescribed at a dose of 10 mg in the period from 11 to 25 days of menstruation. The dose is combined with 0.05 mg of ethinyl estradiol (1 time per day).
If hormone replacement therapy , it is used in combination with estrogens. Continuous treatment involves taking 10 mg of the drug for 14 days during each monthly cycle. If necessary, the dose can be increased to 20 mg per day.
How to take Duphaston for endometrial hyperplasia depends on what other drugs the doctor prescribes for treatment. As a rule, treatment of endometrial hyperplasia involves taking the drug at a dose of 10 mg from days 16 to 25 of the cycle.
How to take Duphaston for an ovarian cyst also depends on the specialist’s prescription. For ovarian cysts, treatment should continue for at least 3 months.
Treatment of follicular ovarian cyst involves prescribing 10 mg of the drug 2 times a day. ovarian dysfunction is being treated , as well as if multifollicular ovaries .
If a woman misses a Duphaston tablet, then an additional dose should not be taken. You need to continue taking it with the next tablet. For convenience, you can count how many tablets are left in the Duphaston package and monitor the regularity of taking it.
For any diagnosis, you should not start drinking Duphaston without a doctor’s prescription.
Until what time is Duphaston used?
In the first trimester of pregnancy, the expectant mother's body experiences the greatest need for progesterone. In most cases, the use of Duphaston during pregnancy is justified until the 20th week, since its further use loses all meaning. Using the product in the early stages has its own principles:
- It is strictly forbidden to independently replace the drug with its analogues;
- the medication is taken according to the doctor’s regimen;
- If alarming symptoms occur, it is recommended to immediately consult your doctor.
You can find out how long to take Duphaston during pregnancy from your doctor.
Interaction
With simultaneous administration of inducers of microsomal enzymes ( Rifampicin , Phenobarbital), it is possible to accelerate the metabolism of dydrogesterone and reduce the effect.
There is no evidence of incompatibility with other drugs.
Duphaston and Proginova can be prescribed in parallel, most often when planning pregnancy. Proginova is an estrogen drug.
Duphaston and Clostilbegit are prescribed in combination for the treatment of infertility. Clostilbegit is a non-steroidal anti-estrogen that stimulates ovulation.
Borovaya uterus and Duphaston - the compatibility of these drugs is controversial. There is information that the herbal medicine boron uterus in combination with Duphaston can provoke bleeding.
special instructions
If Duphaston is used in combination with estrogens, caution must be exercised in patients suffering from vascular diseases, heart disease, kidney disease, diabetes mellitus , epilepsy , and migraine. Also carefully prescribed for liver diseases.
If a woman is prescribed a drug for the purpose of hormone replacement therapy, a series of studies must be carried out before starting, and later, regular mammographic examinations . It is important to take into account all contraindications. The doctor must clearly examine the patient's medical history. During HRT, the tolerability of such treatment should be monitored at certain intervals. There is a possibility of breakthrough bleeding in the first months of therapy. If such bleeding also occurs after a course of treatment, the woman needs to undergo an endometrial biopsy to exclude malignant processes.
Duphaston should not be taken by those who suffer from lactase deficiency, galactose deficiency or malabsorption syndrome.
Does not affect the ability to drive a car or operate precision machinery.
If you regularly experience discharge while taking pills, you should tell your doctor about it.
Since Duphaston is a synthetic progesterone , it can replace the natural hormone progesterone, for which Duphaston is prescribed to pregnant women, as well as women during pregnancy planning. How to drink Duphaston to get pregnant is determined by your attending physician. When asked whether this drug suppresses ovulation, experts answer unequivocally in the negative. How this medicine affects ovulation depends on the frequency and duration of its use.
Often women are interested in whether the drug can cause a delay in menstruation , or how to drink to induce menstruation. It should be understood that the regulation of menstruation is ensured by the production of estrogen and progesterone in the body. Often a woman notes that her period has not started if there is a lack of progesterone in the body. If the ovaries do not produce enough progesterone for any reason, a course of Duphaston is prescribed. If your period does not come after taking Duphaston, you should take a pregnancy test . Provided that there are no periods after discontinuation of the drug, and the woman is not pregnant, she should definitely consult a doctor. The reason for scanty periods after the drug may be a lack of estrogen, late ovulation, or changes in the uterus.
It should be borne in mind that when using Duphaston to induce menstruation “for convenience”, without a doctor’s prior prescription, although a woman induces menstruation, she risks disrupting the functions of the hormonal system. As a result, after uncontrolled treatment, a woman sometimes complains that she has heavy periods after taking pills or that her periods take a long time.
Therefore, the answer to the question whether Duphaston can be taken without a doctor’s prescription is clear: this should not be done.
Another question that interests women: do they get better from Duphaston? Namely, does it make you gain weight if you take it for a long time? Since the active substance of the drug is synthetic progesterone, when asked whether it makes you fat, experts answer in the negative.
Why is menstruation delayed?
Time “X” has arrived, but menstruation has not begun; there are many reasons for the absence of menstruation:
Pregnancy
If there is a delay, or even absence of menstruation for more than 10 days, the first step is to exclude pregnancy. As they say, an unloaded gun fires once a year. That is, despite the protective measures taken, there is still a chance of getting pregnant (see Duphaston during pregnancy).
Postpartum period
Menstruation should not wait at least 4 (or better yet,
weeks after childbirth, despite the fact that the woman adheres to artificial feeding. In the first 6 to 8 weeks after birth, the wound surface of the uterus (at the place where the placenta is located) should heal and grow a new functional layer of the endometrium, ready for desquamation. And if a woman is breastfeeding, then she has increased prolactin in her blood, which inhibits the production of FSH and LH in the pituitary gland, which, accordingly, block the secretion of estrogen and progesterone and changes in the endometrium (transformation and secretion) necessary for its rejection - menstruation.
Puberty
During puberty, an irregular menstrual cycle is considered normal for two years after menarche, which indicates unsteady hormonal levels and constant “jumps” of hormones. There is a shortening or lengthening of the cycle, which is accompanied by either a delay in menstruation or its unexpected onset. If after the specified time the cycle has not been regulated, you should undergo an examination and exclude other causes of delayed menstruation.
Anovulation
Lack of ovulation can occur in a healthy woman in 2–3 menstrual cycles throughout the year (see ovulation test). The corpus luteum does not form due to anovulation, and the proliferative phase does not give way to the secretory phase, that is, the functional layer of the endometrium does not grow and there is nothing to be rejected. Such anovulatory cycles occur due to short-term disruptions in the hypothalamic-pituitary-ovarian system under the influence of various but short-term factors (climate change, stress, physical overload).
Poor nutrition
Poor and insufficient nutrition, including strict diets for weight loss, affect the menstrual cycle. The level of estrogen, which is synthesized not only in the ovaries, but also in adipose tissue, decreases with a sharp weight loss, which leads to hormonal disorders up to the development of amenorrhea.
Overweight
Excess body weight can also cause persistent delays in menstruation, oligomenorrhea and amenorrhea. Estrogens, synthesized in large quantities by adipose tissue, are converted into androgens, which causes hyperandrogenism, cycle disruption and changes in appearance (acne, stretch marks, hirsutism and others).
Artificial or spontaneous termination of pregnancy
Both medical abortion and miscarriage are stressful for the body; sudden changes in hormonal levels after an interrupted pregnancy cause malfunctions in the hypothalamic-pituitary-ovarian system and lead to cycle disruption (short and scanty menstruation, their delay).
Gynecological hormonal diseases
Polycystic ovary syndrome, endometriosis, ovarian tumors and uterine cancer can be accompanied by prolonged delays in menstruation with subsequent bleeding.
Taking hormonal drugs
Preventing pregnancy with hormonal drugs (see oral contraceptives pros and cons) or treating endocrine pathology also affects the regularity of the menstrual cycle and provokes delayed menstruation.
Premenopause
With age, the production of hormones in the ovaries decreases, which is often accompanied by hormonal fluctuations and menstrual irregularities (the body prepares for menopause).
Infectious diseases of the uterus and appendages
Duphaston's analogues
Level 4 ATC code matches:
Lutenil
Any substitute for Duphaston must be approved by your doctor. What can replace this drug depends on the patient’s diagnosis and the individual course of the disease. An analogue in composition is the drug Prajisan , other drugs with a similar effect are Utrozhestan , progesterone in ampoules , etc. The price of Duphaston analogues may be slightly lower.
Utrozhestan or Duphaston - which is better?
A comparison of these drugs indicates that both drugs have similar indications for use. But it’s not difficult to determine what the difference is: Utrozhestan, unlike Duphaston, contains natural progesterone from plant raw materials. Which is better - Duphaston or Utrozhestan - during pregnancy can only be determined individually. But Utrozhestan also has a sedative effect on the body. Sometimes both drugs are prescribed simultaneously during pregnancy.
Which is better: Duphaston or Norkolut?
Norkolut is also used in gynecology. However, it has a different active ingredient – norethisterone. This is a cheaper drug, but you can choose one or another drug only after consulting a doctor.
Prajisan or Duphaston - which is better?
Prajisan is a hormonal drug, an analogue of Duphaston. It has similar indications, but its cost is lower. But still, doctors do not recommend making a decision on replacing funds on your own.
Composition of the drug
The basis of the drug Duphaston is dydrogesterone. This is a synthetic analogue of natural progesterone. Unlike the latter, it has a limited scope of application and selective pharmaceutical action. It affects only the endocrine component of progesterone deficiency, and even then not completely.
The essence of the effect is to ensure the onset of the secretory phase of the menstrual cycle and the release of the egg. There are no sedative or anxiolytic effects. As well as the action to prevent premature birth inherent in natural progesterone, which makes the use of gestational support a controversial decision.
The remaining components included in the composition: glucose monohydrate, talc and others do not have pharmaceutical activity. They act as fillers, provide the shape, weight and physical properties of the drug, as well as solubility in the digestive tract.
Duphaston and alcohol
Since the drug often has to be taken over a long period, many women are interested in whether it is possible to drink alcohol while taking Duphaston. There is no information about this in the instructions for the drug. At the same time, many reviews indicate that alcohol was consumed in small quantities. However, doctors warn that combining alcohol and hormonal drugs can negatively affect hormonal levels, liver function and provoke other negative phenomena. In addition, the effectiveness of the product when combined with alcohol is significantly reduced. For those who become pregnant on Duphaston, alcohol is strictly contraindicated.
How to properly cancel Duphaston
Proper drug withdrawal is a delicate issue that must be approached gradually. The standard tactic is to gradually reduce the dosage by 1/2 tablet of the drug every 7 days. This will avoid sudden changes in hormonal levels and pregnancy failure.
If a pregnant woman takes 2 tablets a day, then she needs to reduce the daily dosage to 1.5 tablets. After another week, the dosage is 1 tablet per day. Thus, the dose of the drug is reduced to zero.
Your doctor will tell you how much Duphaston to take during pregnancy and how to stop it correctly. It may take several weeks for the drug to be completely discontinued.
Duphaston during pregnancy and lactation
The instructions indicate that the drug can be taken during pregnancy. Taking pills during pregnancy is possible in the early stages to prevent miscarriage. Therefore, Duphaston during early pregnancy is prescribed to women who previously suffered from a habitual abortion, or who had a frozen pregnancy. But, as a rule, the doctor recommends that such patients take Duphaston when planning a pregnancy. Whether the drug can be taken, how much to take and how to take Duphaston when planning a pregnancy, the doctor determines after the woman takes tests for progesterone. In the process of discussing the drug Duphaston during pregnancy, reviews from doctors indicate that this drug should be prescribed only after a comprehensive and thorough examination of the patient.
As a rule, during pregnancy planning, the drug is taken for 3-6 months. You need to drink the product from 11 to 25 days. But this scheme is relevant only for women whose monthly cycle is 28 days. The doctor will tell you how much to drink for a different cycle length.
It is also important to know how to stop taking this medicine during pregnancy. Provided that pregnancy occurs while taking the pills, Duphaston should continue to be taken. During gestation, the dosage is 20 mg of the drug per day (in two doses). You should also consider how to properly stop Duphaston during pregnancy. You should definitely consult your doctor about how to reduce the dose and until what week you take the pills. The withdrawal regimen during pregnancy involves taking the drug until the 20th week of pregnancy, but sometimes the period until which time to take the medicine depends on the individual health status of the expectant mother. Some women are advised to stop as early as 16 weeks. But in any case, only a gynecologist should recommend in detail how to cancel Duphaston during pregnancy. You cannot be guided by the advice that other women write on forums or in reviews about the product. After taking and after stopping the drug, it is important to regularly monitor the woman’s condition. During pregnancy, in some cases, Duphaston and Proginova are prescribed simultaneously.
Often pregnant women are interested in how Duphaston affects the body as a whole, in particular, whether they get better from it. It should be noted that weight gain during pregnancy is a physiological process and is not associated with taking pills.
How Duphaston works and what role it plays in the body’s functioning
The direct effect of the medication is based on ensuring the onset of the secretory phase of the menstrual cycle. This leads to the cessation of proliferation (division) of cells in the endometrium - the inner lining of the uterus. Adequate conditions for pregnancy are provided. With an unnaturally long cycle, the duration is reduced and falls within the normal range. The reception and transition of the cycle to the secretory phase have significant physiological significance:
- body temperature rises, including the basal temperature necessary for normal fertilization of the egg;
- the concentration drops, the production of FSH, the formation of new follicles is prevented, therefore, after pregnancy, the probability of further release of eggs is zero;
- The endometrium changes structure, which facilitates the fixation of a fertilized egg in the uterus.
In addition to the main effect, there is a group of “side” beneficial effects:
- endometrial hyperplasia is prevented, only the texture of the internal lining of the uterine structures changes;
- the biochemical activity of estrogen is inhibited, which can cause excessive continued cell growth and the formation of neoplasia (the drug supposedly prevents the development of endometrial cancer and the malignant process, but is not used for the treatment of oncology).
The effect of Duphaston varies, depending on the dosage and the patient’s health condition. The dosage is selected on an individual basis.
Reviews about Duphaston
Women taking hormonal pills Duphaston leave positive reviews in most cases. It is often noted online that the medicine helps to get pregnant, that is, it increases the likelihood of conception.
Reviews of Duphaston when planning pregnancy indicate that if you follow the dosage regimen and under the supervision of doctors, you can get the desired result. However, whether this remedy helps you get pregnant in case of infertility depends on whether the diagnosis was made correctly. Women also write on forums that the drug can significantly alleviate symptoms during menopause.
There are also many positive reviews about the use of the drug for endometriosis , for cysts , for polycystic ovary syndrome , for ovarian cysts etc. The drug is often prescribed in combination (for example, with Proginova ’s drugs, etc.).
Women who have treated endometriosis and other diseases with Duphaston sometimes write about side effects. Most often, when taking pills, patients experience the following side effects: nausea , diarrhea , abdominal pain , general weakness, and excess weight .
Many patients, taking the pills during pregnancy, were able to give birth to healthy babies. Reviews of Duphaston for cycle disorders in most cases indicate that after a course of taking pills, the monthly cycle has stabilized. There are also often positive reviews about Duphaston for delayed periods. Experts on the network also often discuss Duphaston. Reviews from doctors for fibroids and other gynecological diseases indicate that experts consider this drug to be effective.
Among other things, it is often discussed online whether Duphaston is hormonal or not. Patients ask questions about whether the pills are hormonal or not, and to specialists. There are many reviews from those who have been helped by taking the pills to get pregnant. On forums, women discuss whether it is possible to get pregnant while taking the drug, whether it affects ovulation, in particular, whether it suppresses ovulation or not. There are often descriptions of individual situations, for example: “I take the drug, but I don’t have my period,” “I drank it for 10 days, but I don’t have my period.”
Women have many questions about taking the drug, which they ask specialists online. People often ask whether it is possible to take Duphaston during menstruation, whether taking it affects the level of hCG , and whether it is possible to gain weight from it.
Duphaston price, where to buy
The price of Duphaston tablets is, on average, 520-800 rubles. You can buy Duphaston in a Moscow pharmacy with a doctor's prescription. How much Duphaston costs in pharmacies in Novosibirsk, Omsk, Samara depends on the place of sale, but, on average, the cost of the drug is the same. At the Ozerki pharmacy the cost of the drug is on average 550 rubles.
The price of Duphaston in a Kharkov pharmacy does not differ from the cost in other cities (Kyiv, Odessa, Zaporozhye, Dnepropetrovsk, etc.). On average, in Ukraine the cost of Duphaston 10 mg (pack of 20 pieces) is 390 hryvnia.
- Online pharmacies in RussiaRussia
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ZdravCity
- Duphaston tablets p.p.o.
10 mg 112 pcs. JSC Veropharm RUB 3,267 order - Duphaston tab. p/o captivity. 10 mg No. 28 JSC Veropharm
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- Duphaston tab. p/o captivity. 10mg No. 20AO Veropharm
RUR 578 order
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- Duphaston tablets 10 mg No. 20Abbot/Veropharm
RUR 592 order
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RUB 823 order
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