Goldline plus. Reviews of people losing weight, before and after photos, instructions for use 10-15 mg, price

People suffering from excess weight try to find the easiest way to get rid of it. They do not give preference to physical training and the selection of a balanced diet, but choose the pharmacological industry as their assistant, for which they later pay.

The main reason for excess weight is increased appetite, because no one has yet gained weight from the air. Goldline diet pills help to tame this unhealthy feeling. Once the appetite disappears, the person does not eat, which means that he loses his kilograms.

All medications that truly suppress hunger are prescribed by an endocrinologist. In this case, you will first have to undergo tests so that the doctor is convinced that the cause of obesity is overeating. Without a doctor's prescription, they will sell you a dummy or a fake, which can be very harmful.

Compound

The drug contains 10 or 15 mg of sibutramine as an active substance, as well as microcrystalline cellulose (Cellulose microcrystalline), lactose (Lactose), colloidal silicon dioxide (Silicium dioxide colloidal), magnesium stearate (Magnesii stearas).
The composition of the Goldline 10 mg capsule body includes: gelatin (Gelatine), titanium dioxide (Titanium dioxide), sodium lauryl sulfate (Sodium lauryl sulfate), dyes (sunset yellow and quinoline yellow).

To make the body of Goldline 15 mg capsules, the following are used: gelatin (Gelatine), titanium dioxide (Titanium dioxide), sodium lauryl sulfate (Sodium lauryl sulfate).

Composition of the capsule cap: gelatin (Gelatine), titanium dioxide (Titanium dioxide), sodium lauryl sulfate (Sodium lauryl sulfate), dyes (diamond blue and acid fuchsin D&C33).

What is the difference between Goldline and Goldline plus?

Now briefly about the subspecies. You may come across three names for the drug:

Goldline is a product with potent sibutramine. It is available by prescription.
Goldline plus is the same as Goldline, only it contains a second active component - microcrystalline cellulose. The substance made it possible to reduce the content of sibutramine. The manufacturer, by releasing this variety, made the drug more accessible - no prescription is required to purchase it.
Goldline Light. If the first two types are serious anti-obesity medications, then this one is a dietary supplement that will help you lose several kilograms if you combine it with training.

Pharmacodynamics and pharmacokinetics

Goldline is a centrally acting agent for the treatment of obesity.

Its active substance sibutramine is a prodrug that exhibits its pharmacological properties in vivo due to primary and secondary amines - products of drug metabolism, which are characterized by the ability to inhibit the reuptake of monoamines (mainly serotonin and norepinephrine ).

The use of the medicine allows you to increase the feeling of satiety, reduce the need for food, and also increase thermal production. These effects are achieved by increasing the content of neurotransmitters in synapses and, consequently, increasing the activity of central serotonin (type 5-HT) and adrenergic receptors .

Sibutramine also has the ability to act on brown adipose tissue through indirect activation of β3-adrenergic receptors .

Weight loss, in turn, is accompanied by an increase in serum concentrations of high-density lipoproteins and a decrease in the concentrations of low-density lipoproteins, total cholesterol , uric acid and triglycerides.

Neither sibutramine nor its metabolic products:

do not inhibit the enzyme monoamine oxidase (MAO);
do not affect the release of monoamines ;
do not have an affinity for a sufficiently large number of neurotransmitter receptors (including serotonin types 5HT1-, 5HT1A-, 5HT1B-, 5HT2A-, 5HT2C-; adrenergic beta 1, 2 and 3, as well as alpha 1 and 2; dopamine D1 and D2; benzodiazepine , muscarinic , NMDAR, histamine H1-).

After taking p/os, sibutramine is absorbed from the digestive tract by at least 77%. During the first passage through the liver the substance is metabolized under the influence of isoenzyme to mono- and didesmethylsibutramine , which are its active metabolites .

The substance is quickly distributed throughout the tissues. protein binding rate for sibutramine is 97%, for its metabolites - 94%.

T1/2 of sibutramine - 1.1 hours, metabolites - 14 and 16 hours (for mono- and didesmethylsibutramine, respectively). After hydroxylation and conjugation, active metabolites are biotransformed into inactive ones, which are eliminated mainly by the kidneys .

What is this drug and what is it for?

If you believe the description on the insert, then Goldline contains the entire complex of substances necessary for a person to help quickly burn fat. True, this particular type only works if you regularly perform physical exercises. The main function of the drug is a noticeable decrease in appetite.

Description

According to the information in the instructions for use, Goldline Light belongs to a new generation of drugs that help in the fight against excess weight. If you take Goldline capsules daily, they affect fat cells, reduce appetite, and a person is physically unable to absorb large portions.

Conditions of release/sale

I heard that Goldline Light is not available without a prescription, but my friend was not only sold it without any problems, but was also given a discount card after purchase. According to some sources, you don't really need a prescription for Goldline. Others report the opposite. The confusion is due to the fact that there are several subspecies of Goldline.

Contraindications

The drug has a number of contraindications, including:

hypersensitivity to its components;
the patient has organic causes of obesity;
mental illness;
congenital heart defects;
bulimia nervosa or anorexia nervosa ;
Tourette's disease;
decompensated heart failure;
arrhythmia and tachycardia ;
obliterating atherosclerosis of the arteries of the lower extremities;
cardiac ischemia;
cerebrovascular diseases (including, but not limited to, transient cerebral circulatory disorders and strokes );
arterial hypertension (when blood pressure is more than 145/90 mm Hg);
severe kidney or liver dysfunction
pheochromocytoma;
hyperthyroidism;
prostate adenoma , which is accompanied by the appearance of residual urine;
angle-closure glaucoma;
taken in combination with MAO inhibitors or other drugs that affect the central nervous system (and also if less than 14 days have passed since their discontinuation);
simultaneous use of other anorekisgenic drugs ;
established alcohol, drug or drug addiction;
age over 65 years and under 18 years.

It is recommended to prescribe Goldline with caution to patients with mild to moderate disorders of liver and/or kidney function ; neurological disorders (including mental retardation and increased convulsive activity, including a history), motor or verbal tics (including a history); chronic circulatory insufficiency, coronary artery diseases (including a history); cholelithiasis , history of arrhythmia controlled arterial hypertension , as well as if hypertension is noted in the anamnesis.

Side effects

The most common side effects associated with the use of the drug Goldline occur in the first weeks of treatment (they are usually observed during the first month). Over time, their severity and frequency of occurrence decrease.

In general, side effects associated with taking the drug do not pose a threat to health and are reversible.

The most common adverse events (occurring in at least every 10 patients):

insomnia;
loss of appetite;
feeling of dry mouth;
constipation.

Sometimes (occur with a frequency of 1-10%) the following may appear:

headache;
increased anxiety;
dizziness;
paresthesia;
vasodilator effect (including hyperemia of the skin);
moderate increase in heart rate (on average 3-7 beats per minute);
tachycardia;
increased blood pressure (at rest, they increase by an average of 1-3 mm Hg);
heartbeat;
exacerbation of hemorrhoids ;
nausea and change in taste;
increased sweating.

At the initial stages of treatment with Goldline, a more significant change in blood pressure and pulse rate is possible (usually such phenomena are observed in the first 4-8 weeks of taking the drug).

In isolated cases, such clinically significant side effects were recorded as: skin itching, development of flu-like syndrome , dysmenorrhea , back and abdominal pain, edema, paradoxical increase in appetite, drowsiness, bleeding, convulsions, increased thirst, runny nose, depression, mood lability, irritability , nervousness, anxiety, acute interstitial nephritis , rheumatic purpura , transient increase in the activity of liver enzymes in the blood , thrombocytopenia .

One patient with schizoaffective psychosis , which most likely existed before the start of drug treatment, developed acute psychosis .

The body's response to stopping Goldline, which manifests itself in the form of headaches and increased appetite, rarely develops.

evidence that withdrawal symptoms , withdrawal symptoms , or mood disturbances may occur after stopping treatment.

Analogs

If it is impossible to use Goldline Plus, the patient is prescribed an analogue of the drug.

It has a different or similar composition, as well as therapeutic properties:

Name	Release form and composition	Peculiarities
Reduxin	Oral capsules containing sibutramine and microcrystalline cellulose	It has pronounced properties, stimulates metabolic processes, affects the centers of hunger and satiety. Prescribed to patients with obesity and excess weight, which appears as a result of constant overeating and hormonal imbalance. You need to take 1 capsule per day, the duration of the course is determined individually.
Lindaxa	A product in the form of capsules containing sibutramine as an active ingredient	The drug is prescribed to patients who are overweight and have various forms of obesity. Its action is similar to Goldline Plus. The dosage is 1 capsule per day, duration of administration is from 1 to 6 months.
Meridia	Capsules for oral use, active ingredient - sibutramine	The drug is effective for various forms of obesity and metabolic disorders. Prescribed for adults: 1 capsule per day. The duration of use is determined individually, taking into account body weight and other characteristics.

Any of the analogues has the same list of contraindications and side effects as Goldline Plus, so you should not take substitutes without first consulting a doctor.

Goldline Plus is a popular and quite effective means for weight correction. Reviews from many people losing weight confirm that in the initial stages there is a possibility of developing adverse reactions. However, after the course, the opinion of patients is usually positive.

Goldline tablets: instructions for use

How to take Goldline capsules

The starting dose of the drug is 10 mg/day. If the expected effect is not observed when using it (in situations where body weight decreases by less than 2 kg during a month of treatment), as well as if the drug is well tolerated, the dose is increased to 15 mg/day.

If there is no effect even when using a higher dosage (weight decreases by less than 2 kg per month), treatment with sibutramine is stopped.

In patients who do not adequately respond to the prescribed treatment, that is, within three months their weight decreases by less than five percent of the original, the duration of use of Goldline should not exceed 3 months.

The maximum duration of treatment is two years. This is due to the lack of reliable data on the safety and effectiveness of using sibutramine over a longer period of time.

You should not continue taking the drug if, after achieving weight loss during further treatment, the patient again gains three (or more) kilograms.

It is considered advisable to supplement therapy with physical activity and diet. Training should be carried out under the supervision of a specialist who has sufficient practical experience in treating people suffering from obesity.

Instructions for Goldline Light

Goldline Light is a drug produced by the pharmaceutical company Izvarino Pharma LLC.

The official website of the tablets states that this product is not a drug and is used by overweight people who actively use physical activity to lose weight, as a dietary supplement.

The daily dose of the drug contains 48 mg of lipoic acid and 360 mg of L-Carnitine (vitamin BT).

In combination with moderate physical activity and a low-calorie diet, weight loss with the use of the product increases by 22% with regular use for six months. In this case, the concentration of α-lipoic acid should be at least 1% of the weight of the total amount of food eaten.

With moderate intensity physical activity, fat burning increases by 36-55%.

In addition, α-lipoic acid is a good antioxidant , which, due to its ability to dissolve in both non-polar and polar solvents, exhibits its properties both in cells and in the extracellular space.

cATP-dependent protein kinase which influences human eating behavior , resulting in increased energy expenditure and decreased food consumption.

The effect of using the drug is dose-dependent.

In accordance with the instructions, take 1 or 2 Goldline Light capsules approximately 15-20 minutes before the start of training and then within 60-90 minutes after it ends.

Lipoic acid is a medication prescribed for cirrhosis or fatty liver , hepatitis A , and chronic hepatitis . Lipoic acid is not available without a prescription because it often causes the following side effects:

severe allergic reactions (this may be itching, urticaria or systemic allergic reactions);
dyspepsia.

At the same time, in the instructions supplied with the Goldline Light dietary supplement, the manufacturer does not warn about the possibility of developing such side effects.

You should also remember that taking capsules should not be combined with taking any multivitamin complexes , drugs for the treatment of anemia and other drugs that contain calcium, potassium, iron or magnesium ions.

Indications for use

A pharmaceutical is a medicine aimed at suppressing the patient’s appetite and normalizing metabolic processes in the body. At the same time, the drug has pronounced properties due to the content of active components that belong to the group of potent ones.

Main indications for use of the medication:

Obesity of varying severity.
Excess weight that appeared as a result of taking glucocorticoids.
Metabolic disorders due to thyroid pathologies characterized by thyroid-stimulating hormone deficiency.
Weight gain due to progression of type 2 diabetes mellitus.

In addition, the medicine is used as a means of controlling body weight in patients whose weight increases due to constant overeating. In each case, the decision to prescribe the drug is made by a specialist.

Overdose

To date, there is not enough data on sibutramine . An increase in the severity of adverse reactions is considered the most likely.

If a suspected overdose of Goldline occurs, you should notify your doctor.

There are no specific antidotes or special treatment. It is recommended to provide the patient with free breathing and keep the condition of the cardiovascular system . Further therapy is symptomatic.

Timely intake of activated carbon gastric lavage procedure can reduce the absorption of the drug in the intestinal tract .

Patients who have high blood pressure may be prescribed β-blockers .

The effectiveness of hemodialysis or forced diuresis has not been established.

Useful video

About the effectiveness of the drug Goldline, see this video review:

Interaction

The simultaneous use of sibutramine with inhibitors of microsomal oxidation (including the CYP3A4 isoenzyme) increases the plasma concentration of its metabolites, heart rate and provokes a clinically insignificant increase in the QT interval.

The metabolism of sibutramine is accelerated when used in combination with phenytoin , dexamethasone , carbamazepine , rifampicin , phenobarbital and macrolide antibiotics .

Serious interactions are possible in the case of simultaneous administration of several drugs that increase the concentration of serotonin in the blood.

In rare cases, serotonin syndrome develops when sibutramine in combination with:

serotonin reuptake inhibitors , which are used to treat depression and anxiety disorders;
certain antimigraine drugs (for example, dihydroergotamine or sumatriptan );
antitussives ( dextromethorphan );
opioid analgesics ( fentanyl , pentazocine , pethidine ).

Sibutramine has no effect on the action of oral contraceptives .

With simultaneous use of sibutramine with ephedrine , pseudoephedrine , phenylpropanolamine and combination drugs containing these substances, the risk of increased blood pressure and heart rate increases.

The substance does not enhance the negative effects of ethanol, however, drinking alcohol during treatment with Goldline reduces the effectiveness of dietary measures.

special instructions

Goldline diet pills are prescribed only in cases where all other measures aimed at weight loss are ineffective. Treatment should be carried out under the supervision of a specialist who has sufficient experience in weight correction for obesity as part of complex treatment (including physical activity, review of diet, habitual lifestyle, diet).

The period of taking Goldline at a dose of 15 mg should be limited in time.

In the first 8 weeks of treatment, heart rate and blood pressure should be monitored every 2 weeks. After this time, monitoring is carried out once a month.

For patients with arterial hypertension (when the pressure is at the level of 145/90 mm Hg), blood pressure and heart rate are recommended to be monitored more often and more carefully. If the pressure rises above the specified values 2 times, treatment with Goldline is stopped.

The appearance of chest pain, swelling of the legs, and progressive dyspnea may indicate the development of pulmonary hypertension (such conditions require consultation with a doctor).

Women of childbearing age should use effective contraception throughout the entire course of use.

Sibutramine has the ability to reduce salivation, cause a feeling of discomfort in the oral cavity, provoke the development of caries and periodontal , thrush .

During the treatment period, you should refrain from performing work that could potentially threaten your health and life, as well as from driving a car.

Legal status

Since January 24, 2008, sibutramine has been included in the list of potent drugs approved by the Russian government[4][5]. Subject-quantitative accounting is subject only in its own form, but is not subject to the common combination of sibutramine + MCC (for example, in the drug “Reduxin”) [6]

Despite the fact that in 2007 sibutramine was not included in this list (it did not yet exist and there was a PKKN list with an unclear legal status), Svetlana Sukhorukova was arrested in October 2007 and in January 2008 she was sentenced for selling sibutramine in 2007 to 5 years according to Art. 234 of the Criminal Code of the Russian Federation - illegal trafficking of potent substances[7][8][9][10].

Sibutramine is also included in the Prohibited List of the World Anti-Doping Agency (2010) and is classified as a substance prohibited during competitions[11].

Measures restricting the free sale of drugs containing sibutramine took place in 2008-2010 not only in Russia. Campaigns to suspend sales were launched in the United States, a number of European Union countries and Israel[12]. This measure was applied after receiving the results of a study, where long-term use (several years) of 15 mg of sibutramine in patients with hypertension who had suffered a heart attack and stroke revealed a number of severe side effects. The revocation of documents giving the right to trade in pharmacies, according to the wording of the regulatory authorities, is temporary, until special circumstances are clarified. In Ukraine, this ban does not apply to dietary supplements containing sibutramine in a higher dose (35-50 mg), due to the lack of legal procedures for proving the presence of this component in a weight loss product. There are studies suggesting that side effects are associated with the presence of the S-isomer in racemic sibutramine. On the contrary, R-sibutramine has a 2-fold lower risk of developing undesirable consequences [ source not specified 2614 days

]. The presence of an optically pure dosage form containing R-sibutramine could, with a sufficient evidence base, have a positive impact on the current situation.

During pregnancy

The category of action on the developing fetus in accordance with the FDA classification is C. This means that animal studies have established a negative effect of the drug on the fetus, but strictly controlled studies of the use of the drug during pregnancy in humans have not been conducted.

It has also not been established whether sibutramine or its metabolites can pass into breast milk.

This excludes the possibility of using the drug by pregnant women and during breastfeeding.

How not to buy a fake

Purchasing Goldline Light online seems like an attractive opportunity, but with comfort and time savings there is a risk of running into a counterfeit. To avoid this, it is important to remember a few indicators that indicate the original product.

Firstly, try to buy such drugs only at the pharmacy. Secondly, look at the cost. Approximate price in Moscow is 1000–2600 rubles. depending on the area.

What should the packaging be like?

The drug is produced by three manufacturers:

"Izvarino Pharma" (Russia).
"KorolevFarm" (Russia).
Ranbaxy Laboratories Limited (India).

Capsules should be placed in blisters in cardboard boxes. The packaging must contain a barcode and instructions must be included inside.

Fake and original: what's the difference?

Also, Goldline Light fakes can be in plastic jars without instructions on a separate sheet. Pay attention to the contents: the difference between the original and the fake may also be in color. The most common type of counterfeit product is golden capsules. If you are confused by their color, open one: the marsh-colored powder inside will confirm that you are holding a fake in your hands, from which at best you will not get results, and at worst... Well, you get the idea.

Reviews about Goldline

Comments and reviews from those losing weight about Goldline 15 mg and 10 mg are quite contradictory. Some note the high effectiveness of the product (some women claim that by taking capsules for weight loss, they lost 7-8 kg in 3-8 weeks), while others say that taking the drug did not give them the desired result, but only provoked a lot of unpleasant symptoms ( pressure surges, headaches, dizziness, weakness, etc.).

In addition, in some reviews of Goldline diet pills, women complain that after stopping taking the capsules, their appetite noticeably increased, and the lost pounds returned almost immediately.

Doctors in reviews of Goldline tablets write that sibutramine is a potent substance that can be sold in pharmacies only with a prescription. It has quite a lot of contraindications and often provokes side effects.

Thus, they recommend taking the drug for weight loss only after consultation with a specialist and a thorough assessment of your health.

The use of the drug is advisable for obesity (that is, when the patient’s BMI is more than 30 kg/sq. m, in exceptional cases - at least 27 kg/sq. m) and only in the absence of endocrine diseases , heart and vascular , mental disorders and certain individual indicators that can be identified by the attending physician.

Only the attending physician can select the optimal dosage regimen (15 or 10 mg) and determine how long the treatment will be.

Often among reviews of Goldline there are also reviews of Goldline Light. Unlike Goldline, it is not a medicine, but a dietary supplement. As noted by women and girls who have taken the drug, the effect of its use is noticeable only if a low-calorie diet is followed and a sufficient level of physical activity is provided.

Simply taking capsules will not help you lose weight.

Additional Information

According to the instructions, Goldline Plus should be taken if independent attempts to lose weight have not brought tangible results - if within three months the loss of body weight is less than 5 kg.

However, in some cases, doctors recommend starting treatment with a combination of diet and appetite suppressants, such as Goldline Plus, so that at the initial stage, restrictions in food consumption are easier for the patient to tolerate and correct eating habits are initially formed.

Goldline price

Price of diet pills in Russian pharmacies:

from 1000 rub. per capsule 10 mg No. 30;
from 1560 rub. per capsule 10 mg No. 60;
from 1450 rub. per capsule 15 mg No. 30;
from 2300 rub. per capsule 15 mg No. 60;
from 2950 rub. for capsules 15 mg No. 90.

Price Goldline Light - from 450 rubles. for package No. 30, from 700 for package No. 60. In Ukraine, the price of Goldline Light No. 90 is 735 UAH.

The tablets are available with a prescription. If desired, they can be ordered online without a prescription. In large cities (for example, Krasnoyarsk, Moscow or Yekaterinburg), online pharmacies offer to buy Goldline with home delivery.

Online pharmacies in RussiaRussia

ZdravCity

Goldline Plus capsules 15 mg + 153.5 mg 60 pcs. Izvarino Pharma LLC
RUB 3,747 order
Goldline Plus capsules 15mg+153.5mg 90 pcs. Izvarino Pharma LLC
RUR 5,029 order
Goldline Plus capsules 15mg+153.5mg 30 pcs. Izvarino Pharma LLC
RUR 2020 order
Goldline Plus capsules 10mg+158.5mg 60 pcs. Izvarino Pharma LLC
2150 rub. order
Goldline Plus capsules 10mg+158.5mg 30 pcs. Izvarino Pharma LLC
RUB 1,368 order

Release form

The product is produced in capsules placed in blisters of 10 pieces, which, in turn, are placed in cardboard boxes and supplied with instructions. There are packs of 30, 60 and 90 pieces.

Capsules

The medicine is a hard yellow-blue gelatin capsule of the second size, which contains white powder inside.